Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System

A detailed method for preparation of a functional and flexible blood–brain barrier model using porcine brain endothelial cells

(2013) Adjanie Patabendige et al.   BRAIN RESEARCH

Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

(2013) Yutaro Hoshi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Oxymorphone Active Uptake at the Blood–Brain Barrier and Population Modeling of its Pharmacokinetic–Pharmacodynamic Relationship

(2013) Muhammad Waqas Sadiq et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

In vitro, in vivo and in silico models of drug distribution into the brain

(2013) Scott G. Summerfield et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Challenges of Using In Vitro Data for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier

(2013) Noora Sjöstedt et al.   PHARMACEUTICAL RESEARCH

Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats

(2012) Joost Westerhout et al.   AAPS Journal

Establishment of a simplified in vitro porcine blood–brain barrier model with high transendothelial electrical resistance

(2012) Adjanie Patabendige et al.   BRAIN RESEARCH

Development of a Physiologically Based Pharmacokinetic Model for the Rat Central Nervous System and Determination of an In Vitro–In Vivo Scaling Methodology for the Blood–Brain Barrier Permeability of Two Transporter Substrates, Morphine and Oxycodone

(2012) Kathryn Ball et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Diphenhydramine Active Uptake at the Blood–Brain Barrier and Its Interaction with Oxycodone in vitro and in Vivo

(2011) Muhammad Waqas Sadiq et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Quantitative Evaluation of the Impact of Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier on the Predictability of the Unbound Concentrations of Drugs in the Brain Using Cerebrospinal Fluid Concentration as a Surrogate

(2011) H. Kodaira et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Population Pharmacokinetics of Oral Risperidone in Children, Adolescents and Adults with Psychiatric Disorders

(2010) An Thyssen et al.   CLINICAL PHARMACOKINETICS

Regional P-Glycoprotein Activity and Inhibition at the Human Blood–Brain Barrier as Imaged by Positron Emission Tomography

(2010) S Eyal et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias

(2010) W. Blum et al.   HAEMATOLOGICA

Comparison of in vitro cell models in predicting in vivo brain entry of drugs

(2010) Jenni J. Hakkarainen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Model Analysis of the Concentration-Dependent Permeability of P-gp Substrates

(2010) Tatsuhiko Tachibana et al.   PHARMACEUTICAL RESEARCH

Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View

(2010) David Hallifax et al.   PHARMACEUTICAL RESEARCH

Active-Site Concentrations of Chemicals - Are They a Better Predictor of Effect than Plasma/Organ/Tissue Concentrations?

(2009) Margareta Hammarlund-Udenaes   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Addressing Central Nervous System (CNS) Penetration in Drug Discovery: Basics and Implications of the Evolving New Concept

(2009) Andreas Reichel   CHEMISTRY & BIODIVERSITY

Methodologies to Assess Brain Drug Delivery in Lead Optimization

(2009) Margareta Hammarlund-Udenaes et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Improved Measurement of Drug Exposure in the Brain Using Drug-Specific Correction for Residual Blood

(2009) Markus Fridén et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

(2009) Markus Fridén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blood–brain barrier cell line PBMEC/C1-2 possesses functionally active P-glycoprotein

(2009) Winfried Neuhaus et al.   NEUROSCIENCE LETTERS

Assessment of Blood–Brain Barrier Permeability Using the In Situ Mouse Brain Perfusion Technique

(2009) Rong Zhao et al.   PHARMACEUTICAL RESEARCH

Homeostatic mechanisms in dopamine synthesis and release: a mathematical model

(2009) Janet A Best et al.   Theoretical Biology and Medical Modelling

Quantitative Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting Brain and Testis Penetration of Xenobiotic Compounds

(2008) J. Enokizono et al.   DRUG METABOLISM AND DISPOSITION

Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport

(2008) S. Syvanen et al.   DRUG METABOLISM AND DISPOSITION

Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria

(2008) Junichi Kamiie et al.   PHARMACEUTICAL RESEARCH

Effect of P‐Glycoprotein Expression Levels on the Concentration‐Dependent Permeability of Drugs to the Cell Membrane

(2007) Yoshiyuki Shirasaka et al.   JOURNAL OF PHARMACEUTICAL SCIENCES