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Title
The functional roles of TCA cycle metabolites in cancer
Authors
Keywords
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Journal
ONCOGENE
Volume 40, Issue 19, Pages 3351-3363
Publisher
Springer Science and Business Media LLC
Online
2021-04-16
DOI
10.1038/s41388-020-01639-8
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Note: Only part of the references are listed.- Compartmentalized acyl-CoA metabolism and roles in chromatin regulation
- (2020) Sophie Trefely et al. Molecular Metabolism
- Cytokine-like Roles for Metabolites in Immunity
- (2020) Zbigniew Zasłona et al. MOLECULAR CELL
- HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis
- (2019) Florinda Meléndez-Rodríguez et al. Cell Reports
- Effects of Long-Term Citrate Treatment in the PC3 Prostate Cancer Cell Line
- (2019) Carmen Caiazza et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Fumarate hydratase in cancer: A multifaceted tumour suppressor
- (2019) Christina Schmidt et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The multifaceted contribution of α-ketoglutarate to tumor progression: An opportunity to exploit?
- (2019) Houda Abla et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- DNA repair in cancer initiation, progression, and therapy—a double-edged sword
- (2019) Katarzyna Kiwerska et al. JOURNAL OF APPLIED GENETICS
- α-Ketoglutarate links p53 to cell fate during tumour suppression
- (2019) John P. Morris et al. NATURE
- Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor
- (2019) Jing-Yiing Wu et al. MOLECULAR CELL
- Dimethylfumarate Inhibits Colorectal Carcinoma Cell Proliferation: Evidence for Cell Cycle Arrest, Apoptosis and Autophagy
- (2019) Kaluzki et al. Cells
- The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer
- (2018) Harvey R. Fernandez et al. CELL DEATH AND DIFFERENTIATION
- Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations
- (2018) Qiuying Chen et al. Cell Metabolism
- Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair
- (2018) Parker L. Sulkowski et al. NATURE GENETICS
- Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
- (2018) Lukas Bunse et al. NATURE MEDICINE
- Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells
- (2018) Nathaniel Edward Bennett Saidu et al. Oncotarget
- Oxaloacetate induces apoptosis in HepG2 cells via inhibition of glycolysis
- (2018) Ye Kuang et al. Cancer Medicine
- A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation
- (2018) Niamh C. Williams et al. Frontiers in Immunology
- D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization
- (2018) Martin Böttcher et al. OncoImmunology
- Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
- (2018) Samuel K. McBrayer et al. CELL
- Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation
- (2018) Timothy I. Johnson et al. Cell Death & Disease
- Citrate targets FBPase and constitutes an emerging novel approach for cancer therapy
- (2018) Philippe Icard et al. Cancer Cell International
- The role of cellular reactive oxygen species in cancer chemotherapy
- (2018) Haotian Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Epigenetic silencing of ZNF132 mediated by methylation-sensitive Sp1 binding promotes cancer progression in esophageal squamous cell carcinoma
- (2018) Dong Jiang et al. Cell Death & Disease
- Mechanisms of DNA damage, repair, and mutagenesis
- (2017) Nimrat Chatterjee et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Silencing of solute carrier family 13 member 5 disrupts energy homeostasis and inhibits proliferation of human hepatocarcinoma cells
- (2017) Zhihui Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dimethyl Fumarate Controls the NRF2/DJ-1 Axis in Cancer Cells: Therapeutic Applications
- (2017) Nathaniel Edward Bennett Saidu et al. MOLECULAR CANCER THERAPEUTICS
- KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase
- (2017) Yugang Wang et al. NATURE
- BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
- (2017) Simon Raffel et al. NATURE
- Glucose feeds the TCA cycle via circulating lactate
- (2017) Sheng Hui et al. NATURE
- L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
- (2017) Andrew M Intlekofer et al. Nature Chemical Biology
- Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer
- (2017) E A Hanse et al. ONCOGENE
- Characterization of the Role of the Malate Dehydrogenases to Lung Tumor Cell Survival
- (2017) Boxi Zhang et al. Journal of Cancer
- IDH mutations in cancer and progress toward development of targeted therapeutics
- (2016) L. Dang et al. ANNALS OF ONCOLOGY
- Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas
- (2016) Audrey Bouillez et al. CANCER RESEARCH
- The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target
- (2016) Icard Philippe et al. DRUG RESISTANCE UPDATES
- Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest
- (2016) Eva Maria Valesky et al. EXPERIMENTAL DERMATOLOGY
- Dimethylfumarate induces cell cycle arrest and apoptosis via regulating intracellular redox systems in HeLa cells
- (2016) Guocan Han et al. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
- Mitochondria and Cancer
- (2016) Wei-Xing Zong et al. MOLECULAR CELL
- Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
- (2016) Marco Sciacovelli et al. NATURE
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition
- (2016) Seung Min Jeong et al. Scientific Reports
- Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway
- (2015) Xin Xie et al. BRITISH JOURNAL OF PHARMACOLOGY
- Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells
- (2015) Lucas B. Sullivan et al. CELL
- Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
- (2015) Tuomas Laukka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases
- (2015) Salette Martinez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
- (2015) Saverio Tardito et al. NATURE CELL BIOLOGY
- Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
- (2015) Yuhui Jiang et al. NATURE CELL BIOLOGY
- Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors
- (2015) Jeanette E. Eckel-Passow et al. NEW ENGLAND JOURNAL OF MEDICINE
- 3-Bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial-mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth
- (2015) TING-AN WANG et al. ONCOLOGY REPORTS
- Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A
- (2014) Guillermo Mariño et al. MOLECULAR CELL
- R-2-Hydroxyglutarate as the Key Effector of IDH Mutations Promoting Oncogenesis
- (2013) Dan Ye et al. CANCER CELL
- SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
- (2013) Eric Letouzé et al. CANCER CELL
- In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation
- (2013) Paulo A. Gameiro et al. Cell Metabolism
- Fatty Acid Labeling from Glutamine in Hypoxia Can Be Explained by Isotope Exchange without Net Reductive Isocitrate Dehydrogenase (IDH) Flux
- (2013) Jing Fan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
- (2013) Lucas B. Sullivan et al. MOLECULAR CELL
- Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
- (2013) Jaekyoung Son et al. NATURE
- (R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
- (2013) J.-A. Losman et al. SCIENCE
- Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells
- (2013) Hubert Lincet et al. Journal of Ovarian Research
- Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
- (2012) M. Xiao et al. GENES & DEVELOPMENT
- D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects
- (2012) S. M. El Sayed et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Glutaminolysis Activates Rag-mTORC1 Signaling
- (2012) Raúl V. Durán et al. MOLECULAR CELL
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
- (2012) Fabian V. Filipp et al. Pigment Cell & Melanoma Research
- Alpha-ketoglutarate (AKG) inhibits proliferation of colon adenocarcinoma cells in normoxic conditions
- (2012) Wojciech Rzeski et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- SDH mutations in cancer
- (2011) Chiara Bardella et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival
- (2011) Caroline H. Yi et al. CELL
- The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
- (2011) Rasheduzzaman Chowdhury et al. EMBO REPORTS
- Pancreatic cancers require autophagy for tumor growth
- (2011) S. Yang et al. GENES & DEVELOPMENT
- Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein Kinase (MAPK) and Phosphatidylinositol-3-kinase (PI3K)/AKT pathways
- (2011) Jun-ichi Hanai et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth
- (2011) D. Gaglio et al. Molecular Systems Biology
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Reductive carboxylation supports growth in tumour cells with defective mitochondria
- (2011) Andrew R. Mullen et al. NATURE
- The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
- (2010) Patrick S. Ward et al. CANCER CELL
- Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation
- (2010) Jian-Bin Wang et al. CANCER CELL
- Hypoxia and energetic tumour metabolism
- (2010) M Christiane Brahimi-Horn et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism
- (2010) Linda O'Flaherty et al. HUMAN MOLECULAR GENETICS
- Identification of lysine succinylation as a new post-translational modification
- (2010) Zhihong Zhang et al. Nature Chemical Biology
- Metabolic transformation in cancer
- (2009) D. A. Tennant et al. CARCINOGENESIS
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death
- (2009) D A Tennant et al. ONCOGENE
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