Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles

DNA polymerase δ proofreads errors made by DNA polymerase ε

(2020) Chelsea R. Bulock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells

(2020) Maxwell A. Tracy et al.   GENETICS

POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status

(2020) Karl P. Hodel et al.   MOLECULAR CELL

Mismatch repair and DNA polymerase δ proofreading prevent catastrophic accumulation of leading strand errors in cells expressing a cancer-associated DNA polymerase ϵ variant

(2020) Chelsea R Bulock et al.   NUCLEIC ACIDS RESEARCH

A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response

(2020) Hao-Dong Li et al.   JCI Insight

Cancers from novel Pole mutant mouse models provide insights into polymerase-mediated hypermutagenesis and immune checkpoint blockade

(2020) Melissa A. Galati et al.   CANCER RESEARCH

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

(2019) Vimal Parkash et al.   Nature Communications

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

(2019) Xuanxuan Xing et al.   Nature Communications

The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity

(2019) Marta A Garbacz et al.   NUCLEIC ACIDS RESEARCH

Genome architecture and stability in the Saccharomyces cerevisiae knockout collection

(2019) Fabio Puddu et al.   NATURE

Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair

(2018) N. J. Haradhvala et al.   Nature Communications

Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae

(2018) Stephanie R. Barbari et al.   G3-Genes Genomes Genetics

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

(2018) Francis Blokzijl et al.   Genome Medicine

Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load

(2018) Hao-Dong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Scan-o-matic: High-Resolution Microbial Phenomics at a Massive Scale

(2016) Martin Zackrisson et al.   G3-Genes Genomes Genetics

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ

(2015) Kouji Hirota et al.   NUCLEIC ACIDS RESEARCH

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants

(2015) Lindsey N. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replicative DNA Polymerase δ but Not ε Proofreads Errors in Cis and in Trans

(2015) Carrie L. Flood et al.   PLoS Genetics

A Common Cancer-Associated DNA Polymerase   Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

(2014) D. P. Kane et al.   CANCER RESEARCH

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition

(2014) Scott A. Lujan et al.   GENOME RESEARCH

Crystal Structure of Yeast DNA Polymerase ε Catalytic Domain

(2014) Rinku Jain et al.   PLoS One

Precise estimates of mutation rate and spectrum in yeast

(2014) Y. O. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emergence of DNA Polymerase   Antimutators That Escape Error-Induced Extinction in Yeast

(2013) L. N. Williams et al.   GENETICS

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

(2013) David N. Church et al.   HUMAN MOLECULAR GENETICS

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ

(2013) Matthew Hogg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deciphering Signatures of Mutational Processes Operative in Human Cancer

(2013) Ludmil B. Alexandrov et al.   Cell Reports

Mutation Rates, Spectra, and Genome-Wide Distribution of Spontaneous Mutations in Mismatch Repair Deficient Yeast

(2013) Gregory I. Lang et al.   G3-Genes Genomes Genetics

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

(2012) Claire Palles et al.   NATURE GENETICS

Genome instability due to ribonucleotide incorporation into DNA

(2010) Stephanie A Nick McElhinny et al.   Nature Chemical Biology

The Baker's Yeast Diploid Genome Is Remarkably Stable in Vegetative Growth and Meiosis

(2010) K. T. Nishant et al.   PLoS Genetics

Division of Labor at the Eukaryotic Replication Fork

(2008) Stephanie A. Nick McElhinny et al.   MOLECULAR CELL

DNA damage alters DNA polymerase   to a form that exhibits increased discrimination against modified template bases and mismatched primers

(2008) X. Meng et al.   NUCLEIC ACIDS RESEARCH

A genome-wide view of the spectrum of spontaneous mutations in yeast

(2008) M. Lynch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA