Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

DNA polymerase δ proofreads errors made by DNA polymerase ε

(2020) Chelsea R. Bulock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

(2019) Vimal Parkash et al.   Nature Communications

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

(2019) Xuanxuan Xing et al.   Nature Communications

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes

(2019) Mitchell B. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterozygous mutations cause genetic instability in a yeast model of cancer evolution

(2019) Miguel C. Coelho et al.   NATURE

Spontaneous Changes in Ploidy Are Common in Yeast

(2018) Yaniv Harari et al.   CURRENT BIOLOGY

Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair

(2018) N. J. Haradhvala et al.   Nature Communications

Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae

(2018) Stephanie R. Barbari et al.   G3-Genes Genomes Genetics

Adaptive genome duplication affects patterns of molecular evolution in Saccharomyces cerevisiae

(2018) Kaitlin J. Fisher et al.   PLoS Genetics

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

(2018) Karl P Hodel et al.   eLife

Polymerase-mediated ultramutagenesis in mice produces diverse cancers with high mutational load

(2018) Hao-Dong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variant

(2017) Daniel G. Dennis et al.   Scientific Reports

Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences

(2016) Lawrence A. Loeb   CANCER RESEARCH

Development of a Comprehensive Genotype-to-Fitness Map of Adaptation-Driving Mutations in Yeast

(2016) Sandeep Venkataram et al.   CELL

A new practical guide to the Luria–Delbrück protocol

(2015) Qi Zheng   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

(2015) Adam Shlien et al.   NATURE GENETICS

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

(2015) Tony M. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants

(2015) Lindsey N. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replicative DNA Polymerase δ but Not ε Proofreads Errors in Cis and in Trans

(2015) Carrie L. Flood et al.   PLoS Genetics

Volatility of Mutator Phenotypes at Single Cell Resolution

(2015) Scott R. Kennedy et al.   PLoS Genetics

A Common Cancer-Associated DNA Polymerase   Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

(2014) D. P. Kane et al.   CANCER RESEARCH

DNA Replication Error-Induced Extinction of Diploid Yeast

(2014) A. J. Herr et al.   GENETICS

The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes

(2013) Natasha Pashkova et al.   DEVELOPMENTAL CELL

Emergence of DNA Polymerase   Antimutators That Escape Error-Induced Extinction in Yeast

(2013) L. N. Williams et al.   GENETICS

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

(2013) David N. Church et al.   HUMAN MOLECULAR GENETICS

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Mating-Type Genes and MAT Switching in Saccharomyces cerevisiae

(2012) J. E. Haber   GENETICS

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

(2012) Claire Palles et al.   NATURE GENETICS

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Antimutator variants of DNA polymerases

(2011) Alan J. Herr et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Drug-Sensitive DNA Polymerase δ Reveals a Role for Mismatch Repair in Checkpoint Activation in Yeast

(2011) Linda J. Reha-Krantz et al.   GENETICS

Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast

(2011) Alan J. Herr et al.   PLoS Genetics

Concurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancer

(2010) Rintaro Yoshida et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications

(2009) HT Lynch et al.   CLINICAL GENETICS

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ

(2009) Michael K Swan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA polymerase   and   proofreading suppress discrete mutator and cancer phenotypes in mice

(2009) T. M. Albertson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA