Early Isoflurane Exposure Impairs Synaptic Development in Fmr1 KO Mice via the mTOR Pathway

mTOR at the nexus of nutrition, growth, ageing and disease

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The mTOR Inhibitor Rapamycin Prevents General Anesthesia-Induced Changes in Synaptic Transmission and Mitochondrial Respiration in Late Postnatal Mice

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Early Postnatal Exposure to Isoflurane Disrupts Oligodendrocyte Development and Myelin Formation in the Mouse Hippocampus

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Exposure of Developing Brain to General Anesthesia

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Persistent alteration in behavioural reactivity to a mild social stressor in rhesus monkeys repeatedly exposed to sevoflurane in infancy

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Of Men and Mice: Modeling the Fragile X Syndrome

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Early Developmental Exposure to General Anesthetic Agents in Primary Neuron Culture Disrupts Synapse Formation via Actions on the mTOR Pathway

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Neurotoxicity of anesthetics: Mechanisms and meaning from mouse intervention studies

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The genetics of isoflurane-induced developmental neurotoxicity

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Neurogenesis and developmental anesthetic neurotoxicity

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Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway

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Fragile X syndrome

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Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity

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Association Between a Single General Anesthesia Exposure Before Age 36 Months and Neurocognitive Outcomes in Later Childhood

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Molecular Mechanisms of Anesthetic Neurotoxicity

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The mTOR signalling cascade: paving new roads to cure neurological disease

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Lasting impact of general anaesthesia on the brain: mechanisms and relevance

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Prolonged Treatment with Propofol Transiently Impairs Proliferation but Not Survival of Rat Neural Progenitor Cells In Vitro

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Long-term Effects of Single or Multiple Neonatal Sevoflurane Exposures on Rat Hippocampal Ultrastructure

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Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus

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Roles of mTOR Signaling in Brain Development

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Isoflurane Impairs Learning and Hippocampal Long-term Potentiation via the Saturation of Synaptic Plasticity

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mTOR signaling and its roles in normal and abnormal brain development

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Identifying Large-Scale Brain Networks in Fragile X Syndrome

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Mechanistic Insights into Neurotoxicity Induced by Anesthetics in the Developing Brain

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Long-term Differences in Language and Cognitive Function After Childhood Exposure to Anesthesia

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Developmental Stage-dependent Persistent Impact of Propofol Anesthesia on Dendritic Spines in the Rat Medial Prefrontal Cortex

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Are anaesthetics toxic to the brain?

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Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning

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Beyond Anesthetic Properties: The Effects of Isoflurane on Brain Cell Death, Neurogenesis, and Long-Term Neurocognitive Function

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Volatile Anesthetics Rapidly Increase Dendritic Spine Density in the Rat Medial Prefrontal Cortex during Synaptogenesis

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Dysregulation of mTOR Signaling in Fragile X Syndrome

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Early Exposure to Anesthesia and Learning Disabilities in a Population-based Birth Cohort

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Isoflurane and sevoflurane dose-dependently impair hippocampal long-term potentiation

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A Retrospective Cohort Study of the Association of Anesthesia and Hernia Repair Surgery With Behavioral and Developmental Disorders in Young Children

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General Anesthesia Causes Long-Lasting Disturbances in the Ultrastructural Properties of Developing Synapses in Young Rats

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An Assessment of the Effects of General Anesthetics on Developing Brain Structure and Neurocognitive Function

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