Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway
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Title
Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway
Authors
Keywords
Neuronal dendrites, Anesthetics, Dentate gyrus, Neurons, Cognitive impairment, Developmental neuroscience, Learning, Dendritic structure
Journal
PLOS BIOLOGY
Volume 15, Issue 7, Pages e2001246
Publisher
Public Library of Science (PLoS)
Online
2017-07-07
DOI
10.1371/journal.pbio.2001246
References
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Note: Only part of the references are listed.- Molecular neurobiology of mTOR
- (2017) Katarzyna Switon et al. NEUROSCIENCE
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- (2016) Andrew J Davidson et al. LANCET
- Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits
- (2016) Lianyan Huang et al. Science Translational Medicine
- Long-term Effects of Single or Multiple Neonatal Sevoflurane Exposures on Rat Hippocampal Ultrastructure
- (2015) Levana G. Amrock et al. ANESTHESIOLOGY
- Multiple Anesthetic Exposure in Infant Monkeys Alters Emotional Reactivity to an Acute Stressor
- (2015) Jessica Raper et al. ANESTHESIOLOGY
- Development of Dendritic Form and Function
- (2015) Julie L. Lefebvre et al. Annual Review of Cell and Developmental Biology
- Anesthetic Neurotoxicity — Clinical Implications of Animal Models
- (2015) Bob A. Rappaport et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dendritic function in vivo
- (2015) Christine Grienberger et al. TRENDS IN NEUROSCIENCES
- Review
- (2014) Meredith Wagner et al. JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
- Isoflurane Impairs the Capacity of Astrocytes to Support Neuronal Development in a Mouse Dissociated Coculture Model
- (2014) Yun Kyoung Ryu et al. JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
- The Neurology of mTOR
- (2014) Jonathan O. Lipton et al. NEURON
- Early Exposure to Volatile Anesthetics Impairs Long-Term Associative Learning and Recognition Memory
- (2014) Bradley H. Lee et al. PLoS One
- mTOR signaling and its roles in normal and abnormal brain development
- (2014) Nobuyuki Takei et al. Frontiers in Molecular Neuroscience
- Characterization and Quantification of Isoflurane-Induced Developmental Apoptotic Cell Death in Mouse Cerebral Cortex
- (2013) George K. Istaphanous et al. ANESTHESIA AND ANALGESIA
- Distinct long-term neurocognitive outcomes after equipotent sevoflurane or isoflurane anaesthesia in immature rats
- (2013) T.M. Ramage et al. BRITISH JOURNAL OF ANAESTHESIA
- Secreted Frizzled-Related Protein 3 Regulates Activity-Dependent Adult Hippocampal Neurogenesis
- (2013) Mi-Hyeon Jang et al. Cell Stem Cell
- Dendritic Arborization and Spine Dynamics Are Abnormal in the Mouse Model of MECP2 Duplication Syndrome
- (2013) M. Jiang et al. JOURNAL OF NEUROSCIENCE
- mTOR complexes in neurodevelopmental and neuropsychiatric disorders
- (2013) Mauro Costa-Mattioli et al. NATURE NEUROSCIENCE
- Parvalbumin interneurons mediate neuronal circuitry–neurogenesis coupling in the adult hippocampus
- (2013) Juan Song et al. NATURE NEUROSCIENCE
- mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons
- (2013) Miou Zhou et al. NEURON
- Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species
- (2013) Bridgette D. Semple et al. PROGRESS IN NEUROBIOLOGY
- Delayed Environmental Enrichment Reverses Sevoflurane-induced Memory Impairment in Rats
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- Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia
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- Anesthetics Interfere With the Polarization of Developing Cortical Neurons
- (2012) Cyrus David Mintz et al. JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
- Newly Postulated Neurodevelopmental Risks of Pediatric Anesthesia: Theories That Could Rock Our World
- (2012) Stephen Robert Hays et al. JOURNAL OF UROLOGY
- Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy
- (2012) Raymund Y.K. Pun et al. NEURON
- Quantitative assessment of new cell proliferation in the dentate gyrus and learning after isoflurane or propofol anesthesia in young and aged rats
- (2011) Diana M. Erasso et al. BRAIN RESEARCH
- FDA Considers Data on Potential Risks of Anesthesia Use in Infants, Children
- (2011) Bridget M. Kuehn JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Isoflurane Impairs Immature Astroglia Development In Vitro: The Role of Actin Cytoskeleton
- (2011) Nadia Lunardi et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia
- (2011) Eunchai Kang et al. NEURON
- Volatile Anesthetics Rapidly Increase Dendritic Spine Density in the Rat Medial Prefrontal Cortex during Synaptogenesis
- (2010) Adrian Briner et al. ANESTHESIOLOGY
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- (2010) Changlian Zhu et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Branching out: mechanisms of dendritic arborization
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- Neonatal Exposure to Sevoflurane Induces Abnormal Social Behaviors and Deficits in Fear Conditioning in Mice
- (2009) Maiko Satomoto et al. ANESTHESIOLOGY
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- Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling
- (2009) Yingwei Mao et al. CELL
- Fragile x syndrome and autism: from disease model to therapeutic targets
- (2009) Gül Dölen et al. Journal of Neurodevelopmental Disorders
- A Retrospective Cohort Study of the Association of Anesthesia and Hernia Repair Surgery With Behavioral and Developmental Disorders in Young Children
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- Normal Development of Brain Circuits
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- (2007) Lukasz Swiech et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
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