Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice

SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas

(2020) Manit Munshi et al.   Blood Cancer Journal

Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice

(2019) Dániel Csete et al.   Frontiers in Immunology

IL-17 in the immunopathogenesis of spondyloarthritis

(2018) Leonie S. Taams et al.   Nature Reviews Rheumatology

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma

(2018) Roland Schmitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer

(2018) Ankit Malik et al.   IMMUNITY

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

CD11b promotes the differentiation of osteoclasts induced by RANKL through the spleen tyrosine kinase signalling pathway

(2017) Guoxi Yang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

High SYK Expression Drives Constitutive Activation of CD21lowB Cells

(2017) Baerbel Keller et al.   JOURNAL OF IMMUNOLOGY

CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis

(2017) Ahmet Ozen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

(2017) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis

(2016) Long Hang et al.   JOURNAL OF IMMUNOLOGY

ABrucellaspp. Protease Inhibitor Limits Antigen Lysosomal Proteolysis, Increases Cross-Presentation, and Enhances CD8+T Cell Responses

(2016) Lorena M. Coria et al.   JOURNAL OF IMMUNOLOGY

Multilabel immunofluorescence and antigen reprobing on formalin-fixed paraffin-embedded sections: novel applications for precision pathology diagnosis

(2016) Jie Pan et al.   MODERN PATHOLOGY

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics

(2016) Elisabeth Salzer et al.   NATURE IMMUNOLOGY

Fostamatinib, an oral spleen tyrosine kinase inhibitor, in the treatment of rheumatoid arthritis: a meta-analysis of randomized controlled trials

(2016) Sumit Kunwar et al.   RHEUMATOLOGY INTERNATIONAL

Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer

(2015) Mariya O. Krisenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation

(2015) Zhifang Cao et al.   IMMUNITY

The Syk Inhibitor Fostamatinib Decreases the Severity of Colonic Mucosal Damage in a Rodent Model of Colitis

(2015) Guray Can et al.   Journal of Crohns & Colitis

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos

(2014) Yanjiao Shao et al.   Nature Protocols

Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation

(2013) E Hug et al.   ONCOGENE

Construction of a New Growth References for China Based on Urban Chinese Children: Comparison with the WHO Growth Standards

(2013) Xin-Nan Zong et al.   PLoS One

Structural and Biophysical Characterization of the Syk Activation Switch

(2012) Ulrich Grädler et al.   JOURNAL OF MOLECULAR BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: A three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents

(2010) Mark C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice

(2009) Marjolein A. van Maanen et al.   ARTHRITIS AND RHEUMATISM

Structural Insights for Design of Potent Spleen Tyrosine Kinase Inhibitors from Crystallographic Analysis of Three Inhibitor Complexes

(2009) Armando G. Villaseñor et al.   Chemical Biology & Drug Design

Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target

(2008) R. M. Young et al.   BLOOD

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

(2008) Kevin M. Dennehy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY