The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase

The Science of Antibiotic Discovery

(2020) Kim Lewis   CELL

Structure of a nascent membrane protein as it folds on the BAM complex

(2020) David Tomasek et al.   NATURE

AFFINImeter: A software to analyze molecular recognition processes from experimental data

(2019) Ángel Piñeiro et al.   ANALYTICAL BIOCHEMISTRY

Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach

(2019) Hundeep Kaur et al.   JOURNAL OF BIOMOLECULAR NMR

Bacterial outer membrane proteins assemble via asymmetric interactions with the BamA β-barrel

(2019) Matthew T. Doyle et al.   Nature Communications

Chimeric peptidomimetic antibiotics against Gram-negative bacteria

(2019) Anatol Luther et al.   NATURE

A new antibiotic selectively kills Gram-negative pathogens

(2019) Yu Imai et al.   NATURE

A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier

(2019) Elizabeth M. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA

(2019) James Lee et al.   eLife

Logomaker: beautiful sequence logos in Python

(2019) Ammar Tareen et al.   BIOINFORMATICS

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

Monoclonal antibody targeting the β-barrel assembly machine ofEscherichia coliis bactericidal

(2018) Kelly M. Storek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane protein insertion through a mitochondrial β-barrel gate

(2018) Alexandra I. C. Höhr et al.   SCIENCE

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Sequence-Specific Solution NMR Assignments of the β-Barrel Insertase BamA to Monitor Its Conformational Ensemble at the Atomic Level

(2018) Jean-Baptiste Hartmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry

(2018) Dror S. Chorev et al.   SCIENCE

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Molecular mechanisms of membrane targeting antibiotics

(2016) Richard M. Epand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural basis of outer membrane protein insertion by the BAM complex

(2016) Yinghong Gu et al.   NATURE

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

The structure of the  -barrel assembly machinery complex

(2016) J. Bakelar et al.   SCIENCE

Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM

(2016) Matthew G. Iadanza et al.   Nature Communications

Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine

(2016) Christopher Stubenrauch et al.   Nature Microbiology

Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles

(2015) Michael T. Marty et al.   ANALYTICAL CHEMISTRY

The β-barrel membrane protein insertase machinery from Gram-negative bacteria

(2015) Nicholas Noinaj et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

SEDPHAT – A platform for global ITC analysis and global multi-method analysis of molecular interactions

(2015) Huaying Zhao et al.   METHODS

Structural and functional analysis of the β-barrel domain of BamA from Escherichia coli

(2014) Dongchun Ni et al.   FASEB JOURNAL

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Free energy of WALP23 dimer association in DMPC, DPPC, and DOPC bilayers

(2013) Norberto Castillo et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Structural insight into the biogenesis of β-barrel membrane proteins

(2013) Nicholas Noinaj et al.   NATURE

The structural basis of autotransporter translocation by TamA

(2013) Fabian Gruss et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Is the C-terminal insertional signal in Gram-negative bacterial outer membrane proteins species-specific or not?

(2012) Nagarajan Paramasivam et al.   BMC GENOMICS

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Dissection of β-barrel outer membrane protein assembly pathways through characterizing BamA POTRA 1 mutants of Escherichia coli

(2010) Drew Bennion et al.   MOLECULAR MICROBIOLOGY

Nonlinear least-squares data fitting in Excel spreadsheets

(2010) Gerdi Kemmer et al.   Nature Protocols

OMPdb: a database of  -barrel outer membrane proteins from Gram-negative bacteria

(2010) K. D. Tsirigos et al.   NUCLEIC ACIDS RESEARCH

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Membrane protein architects: the role of the BAM complex in outer membrane protein assembly

(2009) Timothy J. Knowles et al.   NATURE REVIEWS MICROBIOLOGY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB

(2008) Stephanie K. Aoki et al.   MOLECULAR MICROBIOLOGY