Manipulation of the Nanoscale Presentation of Integrin Ligand Produces Cancer Cells with Enhanced Stemness and Robust Tumorigenicity

Integrin Subtypes and Nanoscale Ligand Presentation Influence Drug Sensitivity in Cancer Cells

(2020) Jennifer L. Young et al.   NANO LETTERS

Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses

(2020) Yu Chao et al.   Science Advances

Soft Polymeric Matrix as a Macroscopic Cage for Magnetically Modulating Reversible Nanoscale Ligand Presentation

(2020) Siu Hong Dexter Wong et al.   NANO LETTERS

Ligand Diffusion Enables Force‐Independent Cell Adhesion via Activating α5β1 Integrin and Initiating Rac and RhoA Signaling

(2020) Leixiao Yu et al.   ADVANCED MATERIALS

Soft Substrate Promotes Osteosarcoma Cell Self-Renewal, Differentiation, and Drug Resistance Through miR-29b and Its Target Protein Spin 1

(2020) Shun Li et al.   ACS Biomaterials-Science & Engineering

Self‐Strengthening Adhesive Force Promotes Cell Mechanotransduction

(2020) Leixiao Yu et al.   ADVANCED MATERIALS

Anisotropic Nanoscale Presentation of Cell Adhesion Ligand Enhances the Recruitment of Diverse Integrins in Adhesion Structures and Mechanosensing-Dependent Differentiation of Stem Cells

(2019) Siu Hong Dexter Wong et al.   ADVANCED FUNCTIONAL MATERIALS

Surface expression marker profile in colon cancer cell lines and sphere-derived cells suggests complexity in CD26+ cancer stem cells subsets

(2019) Lorena Vázquez-Iglesias et al.   Biology Open

Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update

(2019) Joseph A. Clara et al.   Nature Reviews Clinical Oncology

Cdc42-dependent modulation of rigidity sensing and cell spreading in tumor repopulating cells

(2018) Farhan Chowdhury et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells

(2018) Heemin Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanomedicine for tumor microenvironment modulation and cancer treatment enhancement

(2018) Jingjing Liu et al.   Nano Today

Exosome‑mediated gefitinib resistance in lung cancer HCC827 cells via delivery of miR‑21

(2018) Changwen Jing et al.   Oncology Letters

Hydrogel microenvironments for cancer spheroid growth and drug screening

(2018) Yunfeng Li et al.   Science Advances

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

(2018) Qian Chen et al.   Nature Nanotechnology

Magnetically Tuning Tether Mobility of Integrin Ligand Regulates Adhesion, Spreading, and Differentiation of Stem Cells

(2017) Dexter S. H. Wong et al.   NANO LETTERS

Transcriptional activation of PD-L1 by Sox2 contributes to the proliferation of hepatocellular carcinoma cells

(2017) Feng Zhong et al.   ONCOLOGY REPORTS

A graphene-based chemical nose/tongue approach for the identification of normal, cancerous and circulating tumor cells

(2017) Li Wu et al.   NPG Asia Materials

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Identification and characterization of CD133+CD44+ cancer stem cells from human laryngeal squamous cell carcinoma cell lines

(2017) Jue Wang et al.   Journal of Cancer

Integrins as Therapeutic Targets: Successes and Cancers

(2017) Sabine Raab-Westphal et al.   Cancers

In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy

(2017) Chao Wang et al.   Nature Biomedical Engineering

One-Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid-Switchable Surface Charge for Overcoming Drug Resistance

(2016) Qiang Feng et al.   Small

Identification of stem-like cells and clinical significance of candidate stem cell markers in gastric cancer

(2016) Xiaowei Zhang et al.   Oncotarget

Changes in the methylation status of the Oct3/4, Nanog, and Sox2 promoters in stem cells during regeneration of rat tracheal epithelium after injury

(2016) Ying Zhou et al.   Oncotarget

Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment

(2016) Simon J. Attwood et al.   Scientific Reports

Proposed Mechanisms of Tethered Antimicrobial Peptide Chrysophsin-1 as a Function of Tether Length Using QCM-D

(2015) Lindsay D. Lozeau et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Integrin-Generated Forces Lead to Streptavidin-Biotin Unbinding in Cellular Adhesions

(2014) Carol Jurchenko et al.   BIOPHYSICAL JOURNAL

A mechanically-induced colon cancer cell population shows increased metastatic potential

(2014) Xin Tang et al.   Molecular Cancer

Nanoparticle Tension Probes Patterned at the Nanoscale: Impact of Integrin Clustering on Force Transmission

(2014) Yang Liu et al.   NANO LETTERS

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Licensing of DNA replication, cancer, pluripotency and differentiation: An interlinked world?

(2014) S. Champeris Tsaniras et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression

(2014) Youhua Tan et al.   Nature Communications

Identification of a cancer stem cell-like side population in the HeLa human cervical carcinoma cell line

(2013) KEFANG WANG et al.   Oncology Letters

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

Soft fibrin gels promote selection and growth of tumorigenic cells

(2012) Jing Liu et al.   NATURE MATERIALS

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Nonadhesive Culture System as a Model of Rapid Sphere Formation with Cancer Stem Cell Properties

(2012) Su-Feng Chen et al.   PLoS One

Radiation-Induced Increase in Cell Migration and Metastatic Potential of Cervical Cancer Cells Operates Via the K-Ras Pathway

(2011) Wen-Hong Su et al.   AMERICAN JOURNAL OF PATHOLOGY

Autoimmunity associated with immunotherapy of cancer

(2011) S. M. Amos et al.   BLOOD

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation

(2011) C R Jeter et al.   ONCOGENE

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions

(2010) Farhan Chowdhury et al.   PLoS One