Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell

Dual BACE1 and Cholinesterase Inhibitory Effects of Phlorotannins from Ecklonia cava—An In Vitro and in Silico Study

(2019) Jinhyuk Lee et al.   Marine Drugs

CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway

(2019) Kotaro Furusawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-β25-35 Self-Aggregation and Insulin Glycation: Elucidation of the Molecular Mechanism of Action

(2019) Seong et al.   Marine Drugs

Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β

(2018) Jialing Wang et al.   ACS Chemical Neuroscience

Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells

(2018) Zhuo Wang et al.   Frontiers in Aging Neuroscience

Berberine Alleviates Tau Hyperphosphorylation and Axonopathy-Associated with Diabetic Encephalopathy via Restoring PI3K/Akt/GSK3β Pathway

(2018) Shanshan Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-Neuroinflammatory Property of Phlorotannins from Ecklonia cava on Aβ25-35-Induced Damage in PC12 Cells

(2018) Seungeun Lee et al.   Marine Drugs

Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells

(2017) Jiajia Lin et al.   Oxidative Medicine and Cellular Longevity

Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway

(2017) Wei Hong Toh et al.   TRAFFIC

Puerarin attenuates locomotor and cognitive deficits as well as hippocampal neuronal injury through the PI3K/Akt1/GSK-3β signaling pathway in an in vivo model of cerebral ischemia

(2017) Jinhao Tao et al.   Oncotarget

Amyloid-β as a Modulator of Synaptic Plasticity

(2017) Mordhwaj S. Parihar et al.   JOURNAL OF ALZHEIMERS DISEASE

Monomeric Aβ1–40 and Aβ1–42 Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil

(2016) Julien Roche et al.   BIOCHEMISTRY

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

(2015) Myles R. Minter et al.   JOURNAL OF NEUROCHEMISTRY

Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways

(2015) Yanji Cui et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

First Evidence that Ecklonia cava-Derived Dieckol Attenuates MCF-7 Human Breast Carcinoma Cell Migration

(2015) Eun-Kyung Kim et al.   Marine Drugs

Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s Disease

(2015) Fabian A. Cabezas-Opazo et al.   Oxidative Medicine and Cellular Longevity

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Dangerous Liaisons between Beta-Amyloid and Cholinergic Neurotransmission

(2015) Stefano Govoni et al.   CURRENT PHARMACEUTICAL DESIGN

Overexpression of ribonuclease inhibitor defines good prognosis and suppresses proliferation and metastasis in human colorectal cancer cells via PI3K/AKT pathway

(2014) Y. Tang et al.   Clinical & Translational Oncology

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage

(2013) P. Hemachandra Reddy   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Evaluation of Inhibitory Effect of Phlorotannins from Ecklonia cava on Triglyceride Accumulation in Adipocyte

(2013) Haejin Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons

(2013) Feiyang Liu et al.   NEUROSCIENCE LETTERS

Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H2O2-induced oxidative stress in murine hippocampal HT22 cells

(2012) Sung-Myung Kang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model

(2012) Min-Cheol Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Hyperphosphorylation of Tau Induced by Naturally Secreted Amyloid-β at Nanomolar Concentrations Is Modulated by Insulin-dependent Akt-GSK3β Signaling Pathway

(2012) Takayoshi Tokutake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's Disease

(2012) D. E. Hurtado et al.   JOURNAL OF NEUROSCIENCE

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

(2012) Siva Sundara Kumar Durairajan et al.   NEUROBIOLOGY OF AGING

Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity

(2012) Il-Jun Kang et al.   NEUROTOXICOLOGY

Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death

(2011) Il-Jun Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40Ratios in Alzheimer Disease

(2011) Kris Pauwels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Robust Central Reduction of Amyloid-  in Humans with an Orally Available, Non-Peptidic  -Secretase Inhibitor

(2011) P. C. May et al.   JOURNAL OF NEUROSCIENCE

High mobility group box-1 induces migration of vascular smooth muscle cells via TLR4-dependent PI3K/Akt pathway activation

(2011) Jian Yang et al.   MOLECULAR BIOLOGY REPORTS

Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

(2011) B. DaRocha-Souto et al.   NEUROBIOLOGY OF DISEASE

An Active Fraction of Achyranthes bidentata Polypeptides Prevents Apoptosis Induced by Serum Deprivation in SH-SY5Y Cells Through Activation of PI3K/Akt/Gsk3β Pathways

(2011) Yuntian Shen et al.   NEUROCHEMICAL RESEARCH

Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity

(2010) Hyun Ah Jung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

(2010) Daniel Paris et al.   Journal of Neuroinflammation

Isolation and Identification of Phlorotannins fromEcklonia stoloniferawith Antioxidant and Anti-inflammatory Properties

(2009) A-Reum Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY