Dual BACE1 and Cholinesterase Inhibitory Effects of Phlorotannins from Ecklonia cava—An In Vitro and in Silico Study

BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology

(2018) Finn Peters et al.   ACTA NEUROPATHOLOGICA

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6

(2018) Kaichuan Zhu et al.   BIOLOGICAL PSYCHIATRY

Protective Effect of Sulfated Polysaccharides from Celluclast-Assisted Extract of Hizikia fusiforme Against Ultraviolet B-Induced Skin Damage by Regulating NF-κB, AP-1, and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts

(2018) Lei Wang et al.   Marine Drugs

In Silico Docking and In Vitro Approaches towards BACE1 and Cholinesterases Inhibitory Effect of Citrus Flavanones

(2018) Seungeun Lee et al.   MOLECULES

Neuroprotective Role of Phytochemicals

(2018) Bharath Velmurugan et al.   MOLECULES

Anti-Neuroinflammatory Property of Phlorotannins from Ecklonia cava on Aβ25-35-Induced Damage in PC12 Cells

(2018) Seungeun Lee et al.   Marine Drugs

Antihypertensive effect of an enzymatic hydrolysate from Styela clava flesh tissue in type 2 diabetic patients with hypertension

(2017) Seok-Chun Ko et al.   Nutrition Research and Practice

Octaphlorethol A, a marine algae product, exhibits antidiabetic effects in type 2 diabetic mice by activating AMP-activated protein kinase and upregulating the expression of glucose transporter 4

(2016) Seung-Hong Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-obesity effects of seaweeds of Jeju Island on the differentiation of 3T3-L1 preadipocytes and obese mice fed a high-fat diet

(2016) Min-Cheol Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS  -amyloid in animal models and in Alzheimers disease patients

(2016) M. E. Kennedy et al.   Science Translational Medicine

Anti-Alzheimer's disease potential of coumarins from Angelica decursiva and Artemisia capillaris and structure-activity analysis

(2016) Md. Yousof Ali et al.   Asian Pacific Journal of Tropical Medicine

Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment

(2016) Jaume Folch et al.   NEURAL PLASTICITY

Anti-inflammatory and anti-cancer activities of sterol rich fraction of cultured marine microalga Nannochloropsis oculata

(2016) Kalu Kapuge Asanka Sanjeewa et al.   ALGAE

Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions

(2015) Severin Filser et al.   BIOLOGICAL PSYCHIATRY

Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors

(2015) Jong Hwan Kwak et al.   BIOMATERIALS

Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice

(2015) D. R. Thakker et al.   JOURNAL OF NEUROSCIENCE

New Drugs from Marine Organisms in Alzheimer’s Disease

(2015) Patrizia Russo et al.   Marine Drugs

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

(2015) Ulf Neumann et al.   Molecular Neurodegeneration

BACE1 and cholinesterase inhibitory activities of Nelumbo nucifera embryos

(2014) Hyun Ah Jung et al.   ARCHIVES OF PHARMACAL RESEARCH

Advances in algal drug research with emphasis on enzyme inhibitors

(2014) Kannan R.R. Rengasamy et al.   BIOTECHNOLOGY ADVANCES

Lessons from a Failed γ-Secretase Alzheimer Trial

(2014) Bart De Strooper   CELL

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

(2013) Cyril Cheret et al.   EMBO JOURNAL

Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H2O2-induced oxidative stress in murine hippocampal HT22 cells

(2012) Sung-Myung Kang et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Review of Theoretical Studies for Prediction of Neurodegenerative Inhibitors

(2012) F. Prado-Prado et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secretase expression and activity

(2012) Il-Jun Kang et al.   NEUROTOXICOLOGY

Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death

(2011) Il-Jun Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Phlorotannins from Ecklonia cava (Phaeophyceae): Biological activities and potential health benefits

(2010) Isuru Wijesekara et al.   BIOFACTORS

Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity

(2010) Hyun Ah Jung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Amyloid-β-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Aβ peptide. Implications for the pathogenesis of Alzheimer's disease

(2010) Margarita C Dinamarca et al.   Molecular Neurodegeneration

 -Secretase Inhibition Reduces Spine Density In Vivo via an Amyloid Precursor Protein-Dependent Pathway

(2009) T. Bittner et al.   JOURNAL OF NEUROSCIENCE

α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga,Ecklonia cava

(2009) Sang-Hoon Lee et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol, from Ecklonia cava

(2008) Murat Artan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Eckol protects V79-4 lung fibroblast cells against γ-ray radiation-induced apoptosis via the scavenging of reactive oxygen species and inhibiting of the c-Jun NH2-terminal kinase pathway

(2008) Rui Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Amyloid-cholinesterase interactions

(2008) Nibaldo C. Inestrosa et al.   FEBS Journal