Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-β25-35 Self-Aggregation and Insulin Glycation: Elucidation of the Molecular Mechanism of Action

Effects of All-Atom Molecular Mechanics Force Fields on Amyloid Peptide Assembly: The Case of Aβ16-22 Dimer

(2019) Viet Hoang Man et al.   Journal of Chemical Theory and Computation

Eckol as a Potential Therapeutic against Neurodegenerative Diseases Targeting Dopamine D3/D4 Receptors

(2019) Pradeep Paudel et al.   Marine Drugs

Simulation Studies of Amyloidogenic Polypeptides and Their Aggregates

(2019) Ioana M. Ilie et al.   CHEMICAL REVIEWS

Probing Multi-Target Action of Phlorotannins as New Monoamine Oxidase Inhibitors and Dopaminergic Receptor Modulators with the Potential for Treatment of Neuronal Disorders

(2019) Su Hui Seong et al.   Marine Drugs

De novo aggregation of Alzheimer’s Aβ25-35 peptides in a lipid bilayer

(2019) Amy K. Smith et al.   Scientific Reports

Umbelliferone derivatives exert neuroprotective effects by inhibiting monoamine oxidase A, self-amyloidβ aggregation, and lipid peroxidation

(2019) Su Hui Seong et al.   BIOORGANIC CHEMISTRY

Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β

(2018) Jialing Wang et al.   ACS Chemical Neuroscience

Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective

(2018) Quanguo He et al.   Cells

Anti-Neuroinflammatory Property of Phlorotannins from Ecklonia cava on Aβ25-35-Induced Damage in PC12 Cells

(2018) Seungeun Lee et al.   Marine Drugs

d -Ribose as a Contributor to Glycated Haemoglobin

(2017) Xixi Chen et al.   EBioMedicine

Vanillin Affects Amyloid Aggregation and Non-Enzymatic Glycation in Human Insulin

(2017) Clara Iannuzzi et al.   Scientific Reports

D-ribose-glycation of insulin prevents amyloid aggregation and produces cytotoxic adducts

(2016) Clara Iannuzzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antimicrobial, Antioxidant, and Anticancer Activities of Biosynthesized Silver Nanoparticles Using Marine Algae Ecklonia cava

(2016) Jayachandran Venkatesan et al.   Nanomaterials

In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer’s Disease

(2016) Angelo M. Reggiani et al.   Scientific Reports

Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors

(2015) Jong Hwan Kwak et al.   BIOMATERIALS

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

(2015) Jessica Nasica-Labouze et al.   CHEMICAL REVIEWS

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

(2015) Heledd H. Jarosz-Griffiths et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First Evidence that Ecklonia cava-Derived Dieckol Attenuates MCF-7 Human Breast Carcinoma Cell Migration

(2015) Eun-Kyung Kim et al.   Marine Drugs

How does brain insulin resistance develop in Alzheimer's disease?

(2014) Fernanda G. De Felice et al.   Alzheimers & Dementia

Understanding Amyloid Fibril Nucleation and Aβ Oligomer/Drug Interactions from Computer Simulations

(2013) Phuong Nguyen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Evaluation of Inhibitory Effect of Phlorotannins from Ecklonia cava on Triglyceride Accumulation in Adipocyte

(2013) Haejin Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Amyloid β-Peptide 25–35 Self-Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer’s Disease Process and Treatment

(2012) Marina Naldi et al.   ACS Chemical Neuroscience

Neuroprotective effect of edible brown alga Eisenia bicyclis on amyloid beta peptide-induced toxicity in PC12 cells

(2012) Bo Ra Ahn et al.   ARCHIVES OF PHARMACAL RESEARCH

Role of β-Hairpin Formation in Aggregation: The Self-Assembly of the Amyloid-β(25–35) Peptide

(2012) Luca Larini et al.   BIOPHYSICAL JOURNAL

Dieckol isolated from brown seaweed Ecklonia cava attenuates type ІІ diabetes in db/db mouse model

(2012) Min-Cheol Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death

(2011) Il-Jun Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Phlorotannins of the edible brown seaweed Ecklonia cava Kjellman induce sleep via positive allosteric modulation of gamma-aminobutyric acid type A–benzodiazepine receptor: A novel neurological activity of seaweed polyphenols

(2011) Suengmok Cho et al.   FOOD CHEMISTRY

Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity

(2010) Hyun Ah Jung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Conformations and Biological Activities of Amyloid Beta Peptide 25-35

(2010) L. Millucci et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Isolation and Identification of Phlorotannins fromEcklonia stoloniferawith Antioxidant and Anti-inflammatory Properties

(2009) A-Reum Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol, from Ecklonia cava

(2008) Murat Artan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Role of AGEs in Diabetic Nephropathy

(2008) Kei Fukami et al.   CURRENT PHARMACEUTICAL DESIGN

Acetyl- and butyrylcholinesterase inhibitory activities of sterols and phlorotannins from Ecklonia stolonifera

(2008) Na Y YOON et al.   FISHERIES SCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Insulin rescues amyloid β-induced impairment of hippocampal long-term potentiation

(2007) Cheng-Che Lee et al.   NEUROBIOLOGY OF AGING