Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling

Biomechanical characterization of a chronic type a dissected human aorta

(2020) Marco Amabili et al.   JOURNAL OF BIOMECHANICS

Genetics of Thoracic and Abdominal Aortic Diseases

(2019) Amélie Pinard et al.   CIRCULATION RESEARCH

Targetable cellular signaling events mediate vascular pathology in vascular Ehlers-Danlos syndrome

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Local variations in material and structural properties characterize murine thoracic aortic aneurysm mechanics

(2018) Matthew R. Bersi et al.   Biomechanics and Modeling in Mechanobiology

Central artery stiffness and thoracic aortopathy

(2018) J. D. Humphrey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Absence of LTBP-3 attenuates the aneurysmal phenotype but not spinal effects on the aorta in Marfan syndrome

(2018) A. Korneva et al.   Biomechanics and Modeling in Mechanobiology

A hidden structural vulnerability in the thrombospondin-2 deficient aorta increases the propensity to intramural delamination

(2017) C. Bellini et al.   Journal of the Mechanical Behavior of Biomedical Materials

Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms

(2017) C. Bellini et al.   Journal of the Royal Society Interface

Differential cell-matrix mechanoadaptations and inflammation drive regional propensities to aortic fibrosis, aneurysm or dissection in hypertension

(2017) M. R. Bersi et al.   Journal of the Royal Society Interface

Marfan syndrome; A connective tissue disease at the crossroads of mechanotransduction, TGFβ signaling and cell stemness

(2017) Francesco Ramirez et al.   MATRIX BIOLOGY

Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix PropertiesSignificance

(2016) Jacopo Ferruzzi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Structure of the Elastin-Contractile Units in the Thoracic Aorta and How Genes That Cause Thoracic Aortic Aneurysms and Dissections Disrupt This Structure

(2016) Ashkan Karimi et al.   CANADIAN JOURNAL OF CARDIOLOGY

Hereditary Influence in Thoracic Aortic Aneurysm and Dissection

(2016) Eric M. Isselbacher et al.   CIRCULATION

Mechanical assessment of arterial dissection in health and disease: Advancements and challenges

(2016) Jianhua Tong et al.   JOURNAL OF BIOMECHANICS

Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in MiceSignificance

(2015) Jie Hong Hu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dimorphic Effects of Transforming Growth Factor-β Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan SyndromeSignificance

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Role of Mechanotransduction in Vascular Biology: Focus on Thoracic Aortic Aneurysms and Dissections

(2015) J. D. Humphrey et al.   CIRCULATION RESEARCH

Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer

(2014) Jeremy S. Bredfeldt et al.   JOURNAL OF BIOMEDICAL OPTICS

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

(2014) Wei Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Computational modelling suggests good, bad and ugly roles of glycosaminoglycans in arterial wall mechanics and mechanobiology

(2014) S. Roccabianca et al.   Journal of the Royal Society Interface

Absence of Cardiovascular Manifestations in a Haploinsufficient Tgfbr1 Mouse Model

(2014) Marjolijn Renard et al.   PLoS One

Biomechanical Phenotyping of Central Arteries in Health and Disease: Advantages of and Methods for Murine Models

(2013) J. Ferruzzi et al.   ANNALS OF BIOMEDICAL ENGINEERING

A Microstructurally Motivated Model of Arterial Wall Mechanics with Mechanobiological Implications

(2013) C. Bellini et al.   ANNALS OF BIOMEDICAL ENGINEERING

Perturbations of mechanotransduction and aneurysm formation in heritable aortopathies

(2013) Richmond W. Jeremy et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Difference in hemodynamic and wall stress of ascending thoracic aortic aneurysms with bicuspid and tricuspid aortic valve

(2013) Salvatore Pasta et al.   JOURNAL OF BIOMECHANICS

Mechanical characterisation of the human thoracic descending aorta: experiments and modelling

(2011) Claudio M. García-Herrera et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections

(2010) Sakiko Inamoto et al.   CARDIOVASCULAR RESEARCH

Conditional inactivation of TGF-β type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects

(2010) Dominique Langlois et al.   TRANSGENIC RESEARCH

The Haploinsufficient Col3a1 Mouse as a Model for Vascular Ehlers-Danlos Syndrome

(2010) T. K. Cooper et al.   VETERINARY PATHOLOGY

Absence of TGFβ signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm

(2009) Bibha Choudhary et al.   GENESIS

Cellular and molecular mechanisms of thoracic aortic aneurysms

(2009) Ismail El-Hamamsy et al.   Nature Reviews Cardiology

Vascular Extracellular Matrix and Arterial Mechanics

(2009) Jessica E. Wagenseil et al.   PHYSIOLOGICAL REVIEWS

Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndrome

(2009) J. H. N. Lindeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Basis of Thoracic Aortic Aneurysms and Dissections: Focus on Smooth Muscle Cell Contractile Dysfunction

(2008) Dianna M. Milewicz et al.   Annual Review of Genomics and Human Genetics

Thoracic Aortic Aneurysm: Reading the Enemy's Playbook

(2008) John A. Elefteriades   CURRENT PROBLEMS IN CARDIOLOGY

Regional and directional variations in the mechanical properties of ascending thoracic aortic aneurysms

(2008) Dimitrios C. Iliopoulos et al.   MEDICAL ENGINEERING & PHYSICS