Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation

De novo development of proteolytically resistant therapeutic peptides for oral administration

(2020) Xu-Dong Kong et al.   Nature Biomedical Engineering

MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans

(2019) Alexander W. Koch et al.   BLOOD

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

(2019) Christina U. Lorentz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding

(2019) Rami A. Al‐Horani et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Factor XI(a) inhibitors for thrombosis: an updated patent review (2016-present)

(2019) Rami A. Al-Horani   EXPERT OPINION ON THERAPEUTIC PATENTS

Cyclization of peptides with two chemical bridges affords large scaffold diversities

(2018) Sangram S. Kale et al.   Nature Chemistry

Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212)

(2017) Donald J. P. Pinto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptide Macrocycle Inhibitor of Coagulation Factor XII with Subnanomolar Affinity and High Target Selectivity

(2017) Simon J. Middendorp et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bypassing bacterial infection in phage display by sequencing DNA released from phage particles

(2017) Camille Villequey et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Generation and characterization of aptamers targeting factor XIa

(2017) R.S. Woodruff et al.   THROMBOSIS RESEARCH

Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa

(2017) David A. Donkor et al.   Scientific Reports

Novel phenylalanine derived diamides as Factor XIa inhibitors

(2016) Leon M. Smith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain

(2016) S. S. Wong et al.   BLOOD

Emerging anticoagulant strategies

(2016) James C. Fredenburgh et al.   BLOOD

Improving the Binding Affinity of in-Vitro-Evolved Cyclic Peptides by Inserting Atoms into the Macrocycle Backbone

(2016) Jonas Wilbs et al.   CHEMBIOCHEM

Factor XIa–specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis

(2016) Tovo David et al.   Science Translational Medicine

Factor XI and factor XII as targets for new anticoagulants

(2016) Jeffrey I. Weitz   THROMBOSIS RESEARCH

Pyridine and pyridinone-based factor XIa inhibitors

(2015) James R. Corte et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Factor XI and contact activation as targets for antithrombotic therapy

(2015) D. Gailani et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

(2015) Harry R. Büller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anticoagulation in Chronic Hemodialysis: Progress Toward an Optimal Approach

(2015) Michèle Kessler et al.   SEMINARS IN DIALYSIS

Physician's Fear of Anticoagulant Therapy in Nonvalvular Atrial Fibrillation

(2014) Souvik Sen et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits

(2014) Jonathan W. Yau et al.   BLOOD

Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?

(2014) Andreas Baumann et al.   DRUG DISCOVERY TODAY

Heparin and Albumin as Part of the Priming Solution Limits Exposure to Anticoagulation during Hemodialysis: In Vitro Studies

(2014) Tobias Kyrk et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Fasxiator, a novel factor XIa inhibitor from snake venom, and its site-specific mutagenesis to improve potency and selectivity

(2014) W. Chen et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides

(2014) Inmaculada Rentero Rebollo et al.   NUCLEIC ACIDS RESEARCH

Epidemiologic and clinical data linking factors XI and XII to thrombosis

(2014) N. S. Key   Hematology-American Society of Hematology Education Program

Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates

(2013) Jeffrey R. Crosby et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo

(2013) D. Ma et al.   BLOOD

Improving Binding Affinity and Stability of Peptide Ligands by Substituting Glycines withD-Amino Acids

(2013) Shiyu Chen et al.   CHEMBIOCHEM

Pharmacokinetics and Pharmacokinetic–Pharmacodynamic Correlations of Therapeutic Peptides

(2013) Lei Diao et al.   CLINICAL PHARMACOKINETICS

Discovery of Allosteric Modulators of Factor XIa by Targeting Hydrophobic Domains Adjacent to Its Heparin-Binding Site

(2013) Rajesh Karuturi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits

(2011) Pancras C. Wong et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

What are the anticoagulation options for intermittent hemodialysis?

(2011) Andrew Davenport   Nature Reviews Nephrology

Dosing of Unfractionated Heparin in Obese Patients with Venous Thromboembolism

(2010) Adam N. Hurewitz et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Hemodialysis

(2010) Jonathan Himmelfarb et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI

(2008) E. I. Tucker et al.   BLOOD

Triggers, targets and treatments for thrombosis

(2008) Nigel Mackman   NATURE