Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists

Small molecule glucagon receptor antagonists: an updated patent review (2015–2019)

(2020) Chen Cheng et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction

(2019) Qutuba G. Karwi et al.   Cardiovascular Diabetology

Non-conventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

(2019) Oleg G. Chepurny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antisense Inhibition of Glucagon Receptor by IONIS-GCGRRx Improves Type 2 Diabetes Without Increase in Hepatic Glycogen Content in Patients With Type 2 Diabetes on Stable Metformin Therapy

(2019) Erin S. Morgan et al.   DIABETES CARE

Efficacy and Safety of the Glucagon Receptor Antagonist RVT-1502 in Type 2 Diabetes Uncontrolled on Metformin Monotherapy: A 12-Week Dose-Ranging Study

(2019) Jeremy H. Pettus et al.   DIABETES CARE

Structural Refinement of Glucagon for Therapeutic Use

(2019) Joseph R. Chabenne et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial

(2018) Jeremy Pettus et al.   DIABETES OBESITY & METABOLISM

Hemodynamic Effects of Glucagon: A Literature Review

(2018) Kasper Meidahl Petersen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes

(2018) Sofie Hædersdal et al.   MAYO CLINIC PROCEEDINGS

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice

(2018) Ankit X. Sharma et al.   Cell Reports

Structure of the glucagon receptor in complex with a glucagon analogue

(2018) Haonan Zhang et al.   NATURE

Does glucagon have a positive inotropic effect in the human heart?

(2018) Jesus Hernández-Cascales   Cardiovascular Diabetology

Investigational glucagon receptor antagonists in Phase I and II clinical trials for diabetes

(2017) André J. Scheen et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Extra-helical binding site of a glucagon receptor antagonist

(2016) Ali Jazayeri et al.   NATURE

Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes

(2015) R. P. Kelly et al.   DIABETES OBESITY & METABOLISM

Inhibiting or antagonizing glucagon: making progress in diabetes care

(2015) P. J. Lefèbvre et al.   DIABETES OBESITY & METABOLISM

Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys

(2015) Haruka Okamoto et al.   ENDOCRINOLOGY

Glucagon receptor antagonism induces increased cholesterol absorption

(2015) Hong-Ping Guan et al.   JOURNAL OF LIPID RESEARCH

Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway

(2015) May-Yun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

(2014) Brian Finan et al.   NATURE MEDICINE

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

(2013) K. M. Habegger et al.   DIABETES

Glucagon clearance is regulated by nutritional state: evidence from experimental studies in mice

(2013) Alyssa Zhou et al.   DIABETOLOGIA

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

(2013) B. Finan et al.   Science Translational Medicine

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

(2009) Jonathan W Day et al.   Nature Chemical Biology