Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

What coronavirus 3C‐like protease tells us: From structure, substrate selectivity, to inhibitor design

(2021) Muya Xiong et al.   MEDICINAL RESEARCH REVIEWS

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

(2020) Linlin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak

(2020) Matteo Chinazzi et al.   SCIENCE

Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics

(2020) Arun K. Ghosh et al.   ChemMedChem

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

(2020) Wenhao Dai et al.   SCIENCE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients

(2020) Hai-xia Su et al.   ACTA PHARMACOLOGICA SINICA

Coronavirus breakthrough: dexamethasone is first drug shown to save lives

(2020) Heidi Ledford   NATURE

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

(2020) Robert L. Hoffman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global trial eliminates drugs, pivots to new ones

(2020) Kai Kupferschmidt   SCIENCE

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

(2020) Wayne Vuong et al.   Nature Communications

A Concise Review of Baseline Facts of SARS‐CoV‐2 for Interdisciplinary Research

(2020) Adish Tyagi et al.   ChemistrySelect

A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors**

(2020) Kai S. Yang et al.   ChemMedChem

Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease

(2019) Yuying Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Upgrade of macromolecular crystallography beamline BL17U1 at SSRF

(2018) Qi-Sheng Wang et al.   Nuclear Science and Techniques

Enterovirus A71 Proteins: Structure and Function

(2018) Jingjing Yuan et al.   Frontiers in Microbiology

Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication

(2018) Laurène Da Costa et al.   JOURNAL OF MEDICINAL CHEMISTRY

4-Iminooxazolidin-2-one as a Bioisostere of the Cyanohydrin Moiety: Inhibitors of Enterovirus 71 3C Protease

(2018) Yuying Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of anti-EV71 agents

(2016) Peng Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors

(2016) Yangyang Zhai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68

(2015) Liang Sun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptidyl Aldehyde NK-1.8k Suppresses Enterovirus 71 and Enterovirus 68 Infection by Targeting Protease 3C

(2015) Yaxin Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease

(2015) Yangyang Zhai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Broad-Spectrum Inhibitors against 3C-Like Proteases of Feline Coronaviruses and Feline Caliciviruses

(2015) Yunjeong Kim et al.   JOURNAL OF VIROLOGY

Structures ofEnterovirus 713C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir

(2013) Caiming Wu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: Evaluation of antiviral efficacy in a murine infection model

(2013) Xiaonan Zhang et al.   ANTIVIRAL RESEARCH

Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus

(2013) Sivakoteswara Rao Mandadapu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors

(2013) Allan M. Prior et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Immunogenicity and safety of an enterovirus 71 vaccine in healthy Chinese children and infants: a randomised, double-blind, placebo-controlled phase 2 clinical trial

(2013) Feng-Cai Zhu et al.   LANCET

Antiviral drug discovery for the treatment of enterovirus 71 infections

(2012) Luqing Shang et al.   ANTIVIRAL RESEARCH

Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

(2012) Y. Kim et al.   JOURNAL OF VIROLOGY

Pilot Scale Production of Highly Efficacious and Stable Enterovirus 71 Vaccine Candidates

(2012) Ai-Hsiang Chou et al.   PLoS One

Crystal Structure of Human Enterovirus 71 3C Protease

(2011) Sheng Cui et al.   JOURNAL OF MOLECULAR BIOLOGY

Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

(2011) G. Lu et al.   JOURNAL OF VIROLOGY

Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues

(2011) J. Wang et al.   JOURNAL OF VIROLOGY

Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China

(2010) Yang Wu et al.   Protein & Cell

Enterovirus 71 Infection of Human Dendritic Cells

(2009) Yu-Wen Lin et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Neuropathology in 2 cases of fatal enterovirus type 71 infection from a recent epidemic in the People's Republic of China: a histopathologic, immunohistochemical, and reverse transcription polymerase chain reaction study

(2009) Yu Yang et al.   HUMAN PATHOLOGY

9-Arylpurines as a Novel Class of Enterovirus Inhibitors

(2009) Leire Aguado et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enterovirus 71 3C Protease Cleaves a Novel Target CstF-64 and Inhibits Cellular Polyadenylation

(2009) Kuo-Feng Weng et al.   PLoS Pathogens

Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents

(2008) Chih-Jung Kuo et al.   BIOORGANIC & MEDICINAL CHEMISTRY