Journal
ANTIVIRAL RESEARCH
Volume 97, Issue 2, Pages 183-194Publisher
ELSEVIER
DOI: 10.1016/j.antiviral.2012.12.005
Keywords
Picornavirus; Enterovirus; Enterovirus 71; Antiviral therapy
Categories
Funding
- National Natural Science Foundation of China [20972079, 21202087]
- National Basic Research Program of China (973 program) [2013CB911104]
- Fundamental Research Funds for the Central Universities [65124002, 65011171]
- Scientific Research Starting Foundation of Returned Overseas Chinese Scholars, Ministry of Education of China
- 111 Project of the Ministry of Education of China [B06005]
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Enterovirus 71 (EV71) is a small, positive-sense, single-stranded RNA virus in the genus Enterovirus, family Picornavirus. It causes hand, foot and mouth disease in infants and children, which in a small percentage of cases progresses to central nervous system infection, ranging from aseptic meningitis to fatal encephalitis. Sporadic cases of EV71 infection occur throughout the world, but large epidemics have occurred recently in Southeast Asia and China. There are currently no approved vaccines or antiviral therapies for the prevention or treatment of EV71 infection. This paper reviews efforts to develop antiviral therapies against EV71. (c) 2012 Elsevier B.V. All rights reserved.
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