Nanoparticles Displaying Allergen and Siglec-8 Ligands Suppress IgE-FcεRI–Mediated Anaphylaxis and Desensitize Mast Cells to Subsequent Antigen Challenge

Siglecs as Immune Cell Checkpoints in Disease

(2020) Shiteng Duan et al.   Annual Review of Immunology

CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen

(2019) Shiteng Duan et al.   JOURNAL OF CLINICAL INVESTIGATION

Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety

(2019) Derek K Chu et al.   LANCET

Long-term sublingual immunotherapy for peanut allergy in children: Clinical and immunologic evidence of desensitization

(2019) Edwin H. Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and -F on Immune Cells

(2019) Corwin M. Nycholat et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Short-term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy

(2018) Melanie C. Dispenza et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sialic acid–binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β 2 -integrin–dependent function in human eosinophils

(2018) Daniela J. Carroll et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance

(2018) Oliver T. Burton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells

(2018) Jeremy A. O'Sullivan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Frontline Science: Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils

(2018) Jeremy A. O'Sullivan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tissue-Specific Expression of the Low-Affinity IgG Receptor, FcγRIIb, on Human Mast Cells

(2018) Oliver T. Burton et al.   Frontiers in Immunology

Efficacy and Safety of AR101 in Oral Immunotherapy for Peanut Allergy: Results of ARC001, a Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial

(2018) J. Andrew Bird et al.   Journal of Allergy and Clinical Immunology-In Practice

Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice

(2018) Yadong Wei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AR101 Oral Immunotherapy for Peanut Allergy

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Antigenic Liposomes for Generation of Disease-specific Antibodies

(2018) Kyle J. Bednar et al.   Jove-Journal of Visualized Experiments

Ibrutinib, a Bruton’s tyrosine kinase inhibitor used for treatment of lymphoproliferative disorders, eliminates both aeroallergen skin test and basophil activation test reactivity

(2017) Jennifer A. Regan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell–mediated anaphylaxis

(2017) Yapeng Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis

(2017) Bianca Balbino et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab facilitates rapid oral desensitization for peanut allergy

(2017) Andrew J. MacGinnitie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Food allergen immunotherapy: Current status and prospects for the future

(2016) Robert A. Wood   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A single glycan on IgE is indispensable for initiation of anaphylaxis

(2015) Kai-Ting C. Shade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunoglobulin E Signal Inhibition during Allergen Ingestion Leads to Reversal of Established Food Allergy and Induction of Regulatory T Cells

(2014) Oliver T. Burton et al.   IMMUNITY

Molecular targets on mast cells and basophils for novel therapies

(2014) Ilkka T. Harvima et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells

(2013) Tatsuya Oka et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice

(2013) Laurent L. Reber et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anaphylaxis in America: The prevalence and characteristics of anaphylaxis in the United States

(2013) Robert A. Wood et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis

(2013) Matthew S. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of peanut allergy with a novel Ara h 2–Fcγ fusion protein in mice

(2012) Yu Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions

(2012) Takumi Kiwamoto et al.   PHARMACOLOGY & THERAPEUTICS

Current Understanding of Egg Allergy

(2011) Jean-Christoph Caubet et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Guidelines for the Diagnosis and Management of Food Allergy in the United States: Report of the NIAID-Sponsored Expert Panel

(2010)   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Signal Peptide of the IgE Receptor α-Chain Prevents Surface Expression of an Immunoreceptor Tyrosine-based Activation Motif-free Receptor Pool

(2010) Barbara Platzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine B Cells Regulate Serum IgE Levels in a CD23-Dependent Manner

(2010) L. E. Cheng et al.   JOURNAL OF IMMUNOLOGY

CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions

(2009) Lars Nitschke   IMMUNOLOGICAL REVIEWS

A Minor Catalytic Activity of Src Family Kinases Is Sufficient for Maximal Activation of Mast Cells via the High-Affinity IgE Receptor

(2009) Michael Poderycki et al.   JOURNAL OF IMMUNOLOGY

Inhibition of FcεRI-dependent mediator release and calcium flux from human mast cells by sialic acid–binding immunoglobulin-like lectin 8 engagement

(2007) Hidenori Yokoi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY