FGFR2 fusion proteins drive oncogenic transformation of mouse liver organoids towards cholangiocarcinoma

Molecular targeted therapies: Ready for “prime time” in biliary tract cancer

(2020) Angela Lamarca et al.   JOURNAL OF HEPATOLOGY

A single cell atlas of the human liver tumor microenvironment

(2020) Hassan Massalha et al.   Molecular Systems Biology

Clinicogenomic Analysis of FGFR2-Rearranged Cholangiocarcinoma Identifies Correlates of Response and Mechanisms of Resistance to Pemigatinib

(2020) Ian M. Silverman et al.   Cancer Discovery

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

(2019) Benedetta Artegiani et al.   Cell Stem Cell

Immunogenic neoantigens derived from gene fusions stimulate T cell responses

(2019) Wei Yang et al.   NATURE MEDICINE

TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma

(2019) Lipika Goyal et al.   Cancer Discovery

Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes

(2019) Lulu Sun et al.   NATURE CELL BIOLOGY

Resistance to TRK inhibition mediated by convergent MAPK pathway activation

(2019) Emiliano Cocco et al.   NATURE MEDICINE

A Comprehensive PDX Gastric Cancer Collection Captures Cancer Cell–Intrinsic Transcriptional MSI Traits

(2019) Simona Corso et al.   CANCER RESEARCH

Comprehensive molecular profiling of intra- and extrahepatic cholangiocarcinomas: potential targets for intervention

(2018) Maeve A Lowery et al.   CLINICAL CANCER RESEARCH

Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma

(2018) Milind Javle et al.   JOURNAL OF CLINICAL ONCOLOGY

Development of the liver: Insights into organ and tissue morphogenesis

(2018) Elke A. Ober et al.   JOURNAL OF HEPATOLOGY

RAS–MAPK Reactivation Facilitates Acquired Resistance inFGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR–MEK Blockade

(2018) Bruno Bockorny et al.   MOLECULAR CANCER THERAPEUTICS

Intrahepatic Cholangiocarcinoma: Continuing Challenges and Translational Advances

(2018) Alphonse E. Sirica et al.   HEPATOLOGY

Necroptosis microenvironment directs lineage commitment in liver cancer

(2018) Marco Seehawer et al.   NATURE

A single-cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation

(2017) Li Yang et al.   HEPATOLOGY

LTBPs in biology and medicine: LTBP diseases

(2017) Daniel B. Rifkin et al.   MATRIX BIOLOGY

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH -Mutant Molecular Profiles

(2017) Farshad Farshidfar et al.   Cell Reports

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

(2016) Laura Broutier et al.   Nature Protocols

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

(2016) Da-Hye Lee et al.   Nature Communications

Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts

(2015) Alexis Poncy et al.   DEVELOPMENTAL BIOLOGY

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers

(2015) Sandra Misale et al.   Nature Communications

Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma

(2014) Mitesh J. Borad et al.   PLoS Genetics

Identification of Targetable FGFR Gene Fusions in Diverse Cancers

(2013) Yi-Mi Wu et al.   Cancer Discovery

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL