LC-MS characterized methanolic extract of zanthoxylum armatum possess anti-breast cancer activity through Nrf2-Keap1 pathway: An in-silico, in-vitro and in-vivo evaluation

Didymin by suppressing NF-κB activation prevents VEGF-induced angiogenesis in vitro and in vivo

(2019) Kirtikar Shukla et al.   VASCULAR PHARMACOLOGY

Potential Applications of NRF2 Inhibitors in Cancer Therapy

(2019) Emiliano Panieri et al.   Oxidative Medicine and Cellular Longevity

Chemical profiling, antioxidant, enzyme inhibitory and molecular modelling studies on the leaves and stem bark extracts of three African medicinal plants

(2019) Nabeelah Bibi Sadeer et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Magnoflorine improves sensitivity to doxorubicin (DOX) of breast cancer cells via inducing apoptosis and autophagy through AKT/mTOR and p38 signaling pathways

(2019) Tian Wei et al.   BIOMEDICINE & PHARMACOTHERAPY

Taxifolin binds with LXR (α & β) to attenuate DMBA-induced mammary carcinogenesis through mTOR/Maf-1/PTEN pathway

(2018) Md.Wasimul Haque et al.   BIOMEDICINE & PHARMACOTHERAPY

HPLC-DAD finger printing, antioxidant, cholinesterase, and α-glucosidase inhibitory potentials of a novel plant Olax nana

(2018) Muhammad Ovais et al.   BMC Complementary and Alternative Medicine

Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

(2018) Shireen Chikara et al.   CANCER LETTERS

Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide

(2018) Allison Knickle et al.   FOOD AND CHEMICAL TOXICOLOGY

A comprehensive LC–MS/MS method validation for the quantitative investigation of 37 fingerprint phytochemicals in Achillea species: A detailed examination of A. coarctata and A. monocephala

(2018) Mustafa Abdullah Yilmaz et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Taxifolin possesses anti-cancer activity on the 7,12-Dimethylbenz(a)anthracene-Induced breast cancer in the sprague dawley rats by remodeling nuclear factor Erythroid 2- Kelch-Like ECH-Associated Protein 1-Heme Oxygenase 1 and anti-oxidant pathways

(2018) ShaktiPrasad Pattanayak et al.   Pharmacognosy Magazine

In vitro and in vivo anticancer efficacy potential of Quercetin loaded polymeric nanoparticles

(2018) Ruma Baksi et al.   BIOMEDICINE & PHARMACOTHERAPY

Zanthoxylum armatum DC.: Current knowledge, gaps and opportunities in Nepal

(2018) Nirmala Phuyal et al.   JOURNAL OF ETHNOPHARMACOLOGY

Kaempferol Attenuates ROS-Induced Hemolysis and the Molecular Mechanism of Its Induction of Apoptosis on Bladder Cancer

(2018) Ping Wu et al.   MOLECULES

Simultaneous quantification and identification of flavonoids, lignans, coumarin and amides in leaves of Zanthoxylum armatum using UPLC-DAD-ESI-QTOF–MS/MS

(2017) Vinod Bhatt et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

New chemical constituents from the fruits of Zanthoxylum armatum and its in vitro anti-inflammatory profile

(2017) Zulfa Nooreen et al.   NATURAL PRODUCT RESEARCH

The KEAP1–NRF2 System in Cancer

(2017) Keiko Taguchi et al.   Frontiers in Oncology

Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1α Accumulation

(2016) Suho Seo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Daphnetin ameliorates 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis through Nrf-2-Keap1 and NF-κB pathways

(2016) Abhishek Kumar et al.   BIOMEDICINE & PHARMACOTHERAPY

Daphnetin inhibits TNF-α and VEGF-induced angiogenesis through inhibition of the IKKs/IκBα/NF-κB, Src/FAK/ERK1/2 and Akt signalling pathways

(2016) Abhishek Kumar et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

(2016) Thomas G. Davies et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Chemopreventive Effect of the Dietary Compound Kaempferol on the MCF-7 Human Breast Cancer Cell Line Is Dependent on Inhibition of Glucose Cellular Uptake

(2015) Cláudia Azevedo et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Regulation of apoptosis through bcl-2/bax proteins expression and DNA damage byZanthoxylum alatum

(2015) Indrajit Karmakar et al.   PHARMACEUTICAL BIOLOGY

Bioactive Lignans from Zanthoxylum alatum Roxb. stem bark with cytotoxic potential

(2014) Minky Mukhija et al.   JOURNAL OF ETHNOPHARMACOLOGY

Gracilaria edulis extract induces apoptosis and inhibits tumor in Ehrlich Ascites tumor cells in vivo

(2013) Satyajit Patra et al.   BMC Complementary and Alternative Medicine

Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling

(2013) Lingrui Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Endocrine Disrupting Activities of the Flavonoid Nutraceuticals Luteolin and Quercetin

(2013) Steven K. Nordeen et al.   Hormones & Cancer

Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking

(2012) Michael M. Mysinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isobutylhydroxyamides from the Pericarp of Nepalese Zanthoxylum armatum Inhibit NF1-Defective Tumor Cell Line Growth

(2012) Krishna P. Devkota et al.   JOURNAL OF NATURAL PRODUCTS

Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells

(2012) Hidenobu Fukumura et al.   Journal of Physiological Sciences

How can grafted breast cancer models be optimized?

(2011) Séverine Mollard et al.   CANCER BIOLOGY & THERAPY

Searching for Novel Cancer Chemopreventive Plants and their Products:The Genus Zanthoxylum

(2011) Francesco Epifano et al.   CURRENT DRUG TARGETS

Breast cancer cell survival signal is affected by bergapten combined with an ultraviolet irradiation

(2010) Maria Luisa Panno et al.   FEBS LETTERS

Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats

(2009) Lalitsingh Ranawat et al.   JOURNAL OF ETHNOPHARMACOLOGY

X-ray Crystal Structure of Human Heme Oxygenase-1 with (2R,4S)-2-[2-(4-Chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4[((5-trifluoromethylpyridin-2-yl)thio)methyl]-1,3-dioxolane: A Novel, Inducible Binding Mode

(2009) Mona N. Rahman et al.   JOURNAL OF MEDICINAL CHEMISTRY

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Berberine Inhibits Growth of the Breast Cancer Cell Lines MCF-7 and MDA-MB-231

(2008) Jong Kim et al.   PLANTA MEDICA