Article
Agriculture, Multidisciplinary
Wenjia He, Oskar Laaksonen, Ye Tian, Tuuli Haikonen, Baoru Yang
Summary: The phenolic profiles and other major metabolites in European pear juices were investigated using UHPLC-DAD-ESI-QTOF-MS and GC-FID. A total of 39 phenolic compounds were detected, and the content variations were mainly dependent on the cultivar. The genetic background and breeding selections also played a role in the chemical compositions. The results provide important information for industry and pear breeding.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Soraia I. Pedro, Tiago A. Fernandes, Angelo Luis, Alexandra M. M. Antunes, Jose C. Goncalves, Jorge Gominho, Eugenia Gallardo, Ofelia Anjos
Summary: This study evaluated the potential industrial applications of various Acacia species by examining their chemical composition, antioxidant, and antimicrobial properties. Among the studied species, A. pycnantha exhibited a higher concentration of total phenolic compounds and displayed notable antibacterial activity. Vibrational spectroscopy was a reliable method for distinguishing between species.
Article
Plant Sciences
Soraia I. Pedro, Tiago Rosado, Celina Barroca, Duarte Neiva, Vanesa Alonso-Herranz, Ana Gradillas, Antonia Garcia, Jorge Gominho, Eugenia Gallardo, Ofelia Anjos
Summary: Acacia spp. is an invasive species widely distributed in Portugal. It has been found that Acacia flowers contain high concentrations of phenolic compounds and flavonoids. The composition of these compounds varies among different species and flowering stages, and can be distinguished through analysis of FTIR-ATR spectra data of the extracts.
Article
Chemistry, Applied
Xin-Ke Zhang, Xu Zhao, Shi Ying, Chang-Qing Duan
Summary: This study investigated the formation mechanism of Pinotin A in aged red wine using experimental and theoretical approaches. A three-step reaction mechanism involving reversible addition reaction, decarboxylation, and autooxidation was proposed and verified, with the autooxidation step playing a crucial role in the overall reaction.
Article
Chemistry, Applied
Diletta Piatti, Simone Angeloni, Filippo Maggi, Giovanni Caprioli, Massimo Ricciutelli, Lolita Arnoldi, Stefania Bosisio, Giacomo Mombelli, Ettore Drenaggi, Gianni Sagratini
Summary: The polar extracts and essential oils of sea fennel cultivated in central Italy were analyzed. The extracts contained 21 bioactive compounds, with 5-O-caffeoylquinic acid being the most abundant. Melatonin, a hormone that regulates sleep/wake cycle, was identified for the first time in sea fennel extract. The essential oil was mainly composed of monoterpene hydrocarbons and oxygenated monoterpenes. This study highlights the potential use of sea fennel as an edible plant and a source of nutraceutical compounds.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Chemistry, Applied
Christof B. Steingass, Jonas Burkhardt, Vicky Baeumer, Keshav Kumar, Heiko Mibus-Schoppe, Jana Zinkernagel, Patricia Esquivel, Victor M. Jimenez, Ralf Schweiggert
Summary: Anthocyanins were characterized in red cabbage, sweet potato, and Tradescantia pallida leaves. Various non-, mono-, and diacylated cyanidins were identified in red cabbage. Sweet potato leaves contained mono- and diacylated cyanidin- and peonidin glycosides, while T. pallida leaves mainly contained tetra-acylated anthocyanin tradescantin. The thermal stability of red cabbage and purple sweet potato extracts surpassed that of a commercial food dye, but still fell short compared to the stability of Tradescantia extract.
Article
Biochemistry & Molecular Biology
Yeong Ran Im, Inhwan Kim, Jihyun Lee
Summary: The outer layer of purple sweet potato is a potential source of phenolics, especially anthocyanins, and exhibits high antioxidant activity. Cultivars 'Sinjami' and 'Jami' have higher levels of anthocyanins and other phenolic compounds in their outer layers, contributing to greater antioxidant activity.
Article
Chemistry, Medicinal
Daniel Mendez, Julio C. Escalona-Arranz, Enrique Molina Perez, Kenn Foubert, An Matheeussen, Emmy Tuenter, Ann Cuypers, Paul Cos, Luc Pieters
Summary: Coccoloba cowellii Britton is an endemic and critically endangered plant species with promising antifungal activity, particularly effective against Cryptococcus neoformans and various Candida spp. Its total methanolic extract showed higher and broader antifungal activity compared to its fractions and isolated compounds.
Article
Chemistry, Applied
Zijian Liang, Pangzhen Zhang, Yun Xiong, Stuart K. Johnson, Zhongxiang Fang
Summary: This study characterized the phenolic and carotenoid profiles of the Australian native bulb plant, Haemodorum spicatum, using HPLC-DAD-ESI-QTOF-MS/MS and HPLC-DAD. The results identified 40 phenolic compounds and 2 carotenoids, with 35 compounds being reported for the first time in H. spicatum.
Article
Biochemistry & Molecular Biology
Simon-Okomo Aloo, Fred-Kwame Ofosu, Deog-Hwan Oh
Summary: The study found that sprouts are healthier and more nutritionally rich than raw seeds, with stronger antioxidant, antidiabetic, and antiobesity activities. Sprouting leads to higher levels of metabolites in sprouts compared to raw seeds, making it a suitable technique for altering the functional properties of edible seeds depending on the desired activity.
Article
Biochemistry & Molecular Biology
K. Jony Susanna, Rahul Gajbhiye, Bhaskar Sarmah, Sachin Dattram Pawar, Pakhuri Mehta, Upadhyayula Suryanarayana Murty, V Ravichandiran, Amit Alexander, Pramod Kumar
Summary: The combination of anastrozole and piperine was proposed to enhance the bioavailability of both compounds. A simple, accurate, sensitive, reliable, and economic analytical method was developed for the simultaneous estimation of anastrozole and piperine. Fourteen degradants were characterized and found to have good human oral absorption. This study reveals the potential of this new combination for the treatment of breast cancer.
CURRENT DRUG METABOLISM
(2022)
Article
Biochemical Research Methods
Rosa Padilla, Vincent Gaillard, Thao Nhi Le, Floriant Bellvert, David Chapulliot, Xavier Nesme, Yves Dessaux, Ludovic Vial, Celine Lavire, Isabelle Kerzaon
Summary: Opines are low-molecular-weight metabolites specifically synthesized by agrobacteria-transformed plant cells during crown gall and hairy root diseases. A new analytical method using UHPLC-ESI-MS-QTOF was developed for opine detection, showing high sensitivity and specificity across different plant extracts. This method is a powerful tool for plant gall analysis and disease diagnosis, allowing for the detection of various opines in a single run with accurate quantification.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Food Science & Technology
Adrieli Rodrigues da Costa Nunes, Claudete Aparecida Mangolin, Arildo Jose Braz de Oliveira, Regina Aparecida Correia Goncalves, Alexandre da Silva Avincola, Rafaela Takako Ribeiro de Almeida, Eduardo Jorge Pilau, Maria de Fatima Pires da Silva Machado
Summary: The study found that the cladode extract from Cereus peruvianus grown in the southern region of Brazil contains abundant phenolic compounds and antioxidant activity, including flavonoids that have not been reported before. These phenolic compounds linked to antioxidant activities support the use of this species as a source of natural antioxidants in human food.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mirtha Navarro-Hoyos, Elizabeth Arnaez-Serrano, Maria Isabel Quiros-Fallas, Felipe Vargas-Huertas, Krissia Wilhelm-Romero, Felipe Vasquez-Castro, Diego Alvarado-Corella, Andres Sanchez-Kopper
Summary: This study analyzed the compounds found in Physalis peruviana fruits and husks from Costa Rica using ultra-performance liquid chromatography coupled with high-resolution mass spectrometry. A total of 66 different compounds were identified. The results suggest that the husks and fruits of Physalis peruviana from Costa Rica may have potential health benefits.
Article
Biochemistry & Molecular Biology
Arthur Ferrari Teixeira, Jacqueline de Souza, Douglas Daniel Dophine, Jose Dias de Souza Filho, Denia Antunes Saude-Guimaraes
Summary: In this study, the active components in the ethanolic extract from Eruca sativa leaves were identified, and their hypouricaemic effect on hyperuricaemia was demonstrated. Kaempferol-3,4 '-di-O-beta-glucoside was identified as one of the major components and considered as an important chemical and biological marker of the ethanolic extract.
Review
Medicine, Research & Experimental
Arbind Kumar, Aashish Sharma, Narendra Vijay Tirpude, Sharad Thakur, Sanjay Kumar
Summary: In late 2019, a highly infectious and life-threatening virus called COVID-19 was first reported in Wuhan, China, and quickly spread globally. It belongs to the coronavirus family and causes severe respiratory disease similar to SARS. The pandemic has led to increasing morbidity and mortality rates, especially among vulnerable populations. Proper screening and early interventions are necessary to control the transmission and reduce the risk of severe complications. Diagnostic assays include molecular detection of viral genetic material and serological tests for detecting antibodies. Currently, there are no effective prophylactics or therapeutics, but some drugs are showing promising antiviral activity and are being tested in clinical trials. This review provides an insight into the laboratory detection methods for COVID-19 and the clinical stage of recommended drugs/vaccines against the novel SARS-CoV-2 virus.
CURRENT MOLECULAR MEDICINE
(2023)
Article
Plant Sciences
Narendra Vijay Tirpude, Anamika Sharma, Monika Kumari, Neha Bhardwaj
Summary: The study demonstrates that vitexin can alleviate allergic asthma through regulating oxidative stress, autophagy, and apoptosis. It shows protective effects in various aspects and has a potential therapeutic value.
Review
Immunology
Arbind Kumar, Aashish Sharma, Narendra Vijay Tirpude, Suresh Sharma, Yogendra S. Padwad, Sanjay Kumar
Summary: This article discusses the severity and risk factors of hypercytokinemia in COVID-19 patients, with a special emphasis on prospective immunomodulatory therapies. Timely administration of immunomodulatory drugs may help mitigate the severity of the disease, reduce hospital stay, and lower mortality rate.
INFLAMMOPHARMACOLOGY
(2022)
Article
Immunology
Narendra Vijay Tirpude, Anamika Sharma, Neha Bhardwaj
Summary: This study found that agnuside has a preventive effect on allergic asthma by suppressing inflammatory cell infiltration, congestion, fibrosis, airway remodeling, and alveolar collapse. Agnuside also reduces the expression of allergic inflammatory mediators and oxidative stress molecules, and modulates myeloid cell activation and Tregs in allergic asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rohit Sharma, Ravi Kumar, Anamika Sharma, Abhishek Goel, Yogendra Padwad
Summary: Cellular senescence is a major hallmark of aging, and chronic consumption of green tea catechin epigallocatechin gallate (EGCG) can mitigate the progression of cellular senescence in adipose and intestinal tissues. EGCG attenuates DNA damage, inflammation, immunosenescence, and gut dysbiosis associated with aging, while promoting nutrient signaling mediators and preserving microbial diversity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Immunology
Anamika Sharma, Narendra Vijay Tirpude, Neha Bhardwaj, Dinesh Kumar, Yogendra Padwad
Summary: The present study investigated the anti-arthritic efficacy and molecular mechanism of BLFE and its phytoconstituents berberine and rutin. The findings showed that BLFE, rutin and berberine effectively reduced disease severity index, articular damage, immune cell influx, and pannus formation. They also regulated levels of various cytokines, enzymes, and signaling molecules involved in inflammation. These phytoconstituents exert their effects through the modulation of multiple molecular pathways.
INFLAMMOPHARMACOLOGY
(2022)
Article
Biology
Prateek Singh, Rajat Ujjainiya, Satyartha Prakash, Salwa Naushin, Viren Sardana, Nitin Bhatheja, Ajay Pratap Singh, Joydeb Barman, Kartik Kumar, Saurabh Gayali, Raju Khan, Birendra Singh Rawat, Karthik Bharadwaj Tallapaka, Mahesh Anumalla, Amit Lahiri, Susanta Kar, Vivek Bhosale, Mrigank Srivastava, Madhav Nilakanth Mugale, C. P. Pandey, Shaziya Khan, Shivani Katiyar, Desh Raj, Sharmeen Ishteyaque, Sonu Khanka, Ankita Rani, Promila, Jyotsna Sharma, Anuradha Seth, Mukul Dutta, Nishant Saurabh, Murugan Veerapandian, Ganesh Venkatachalam, Deepak Bansal, Dinesh Gupta, Prakash M. Halami, Muthukumar Serva Peddha, Ravindra P. Veeranna, Anirban Pal, Ranvijay Kumar Singh, Suresh Kumar Anandasadagopan, Parimala Karuppanan, Syed Nasar Rahman, Gopika Selvakumar, Subramanian Venkatesan, Malay Kumar Karmakar, Harish Kumar Sardana, Anamika Kothari, Devendra Singh Parihar, Anupma Thakur, Anas Saifi, Naman Gupta, Yogita Singh, Ritu Reddu, Rizul Gautam, Anuj Mishra, Avinash Mishra, Iranna Gogeri, Geethavani Rayasam, Yogendra Padwad, Vikram Patial, Vipin Hallan, Damanpreet Singh, Narendra Tirpude, Partha Chakrabarti, Sujay Krishna Maity, Dipyaman Ganguly, Ramakrishna Sistla, Narender Kumar Balthu, Kiran A. Kumar, Siva Ranjith, B. Vijay Kumar, Piyush Singh Jamwal, Anshu Wali, Sajad Ahmed, Rekha Chouhan, Sumit G. Gandhi, Nancy Sharma, Garima Rai, Faisal Irshad, Vijay Lakshmi Jamwal, Masroor Ahmad Paddar, Sameer Ullah Khan, Fayaz Malik, Debashish Ghosh, Ghanshyam Thakkar, S. K. Barik, Prabhanshu Tripathi, Yatendra Kumar Satija, Sneha Mohanty, Md Tauseef Khan, Umakanta Subudhi, Pradip Sen, Rashmi Kumar, Anshu Bhardwaj, Pawan Gupta, Deepak Sharma, Amit Tuli, Saumya Ray Chaudhuri, Srinivasan Krishnamurthi, L. Prakash, Ch Rao, B. N. Singh, Arvindkumar Chaurasiya, Meera Chaurasiya, Mayuri Bhadange, Bhagyashree Likhitkar, Sharada Mohite, Yogita Patil, Mahesh Kulkarni, Rakesh Joshi, Vaibhav Pandya, Sachin Mahajan, Amita Patil, Rachel Samson, Tejas Vare, Mahesh Dharne, Ashok Giri, Sachin Mahajan, Shilpa Paranjape, G. Narahari Sastry, Jatin Kalita, Tridip Phukan, Prasenjit Manna, Wahengbam Romi, Pankaj Bharali, Dibyajyoti Ozah, RaviKumar Sahu, Prachurjya Dutta, Moirangthem Goutam Singh, Gayatri Gogoi, Yasmin Begam Tapadar, Elapavalooru V. S. S. K. Babu, Rajeev K. Sukumaran, Aishwarya R. Nair, Anoop Puthiyamadam, Prajeesh Kooloth Valappil, Adrash Velayudhan Pillai Prasannakumari, Kalpana Chodankar, Samir Damare, Ved Varun Agrawal, Kumardeep Chaudhary, Anurag Agrawal, Shantanu Sengupta, Debasis Dash
Summary: Data science has played a crucial role in the COVID-19 pandemic response, and this study demonstrates how a statistical and machine learning approach can be used to discriminate between SARS-CoV-2 infection and immune response to a whole virion vaccine. By analyzing serial antibody data and incorporating an ensemble ML model, the researchers were able to accurately classify potential infections and validate their findings through neutralization assays. This study highlights the importance of real-world vaccine effectiveness assessments for whole virion vaccines.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Arbind Kumar, Aashish Sharma, Narendra Vijay Tirpude, Yogendra Padwad, Vipin Hallan, Sanjay Kumar
Summary: The SARS-CoV-2 outbreak has presented numerous challenges to the global healthcare and socioeconomic systems. Plant-derived immune adjuvants can enhance vaccine effectiveness and stimulate the necessary immune response to combat COVID-19.
PHARMACOLOGICAL REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sourabh Soni, Prince Anand, Mohit Kumar Swarnkar, Vikram Patial, Narendra V. Tirpude, Yogendra S. Padwad
Summary: Transcriptome analysis revealed the role of MK2 in HNSCC and identified a pool of crucial MK2-regulated candidate genes, elucidating their potential involvement in the pathogenesis of HNSCC. These genes have investigative values as targets for diagnosis and therapeutic interventions for HNSCC.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Anamika Sharma, Mohd Adil Khan, Narendra Vijay Tirpude
Summary: This study identified the attributes and mechanisms of leupeptin in relation to immune homeostasis and inflammatory mechanism in activated macrophages and lymphocytes, particularly in the context of ROS-cytokines-autophagy-inflammatory signalling cascades. Leupeptin treatment showed significant inhibition in the production of inflammatory factors and restored impaired autophagy flux. These findings suggest that leupeptin could be a promising natural entity for modulating immune-mediated response during inflammatory disorders.
Article
Pharmacology & Pharmacy
A. K. Maurya, A. Sharma, S. Mukhia, D. Rani, A. Kumar, D. Kumar, R. Kumar, Y. S. Padwad, G. Chand, V. K. Agnithotri
Summary: This study examined the composition, biological activities, and safety evaluation of Hedychium spicatum seeds' essential oil. The oil was found to contain various components, with beta-pinene being the most abundant. The essential oil showed cytotoxic activity against human skin, lung, and cervical cancer cells, as well as antibacterial properties against certain bacteria.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)