Sublingual vaccination and delivery systems

Novel technology for storage and distribution of live vaccines and other biological medicines at ambient temperature

(2020) Irnela Bajrovic et al.   Science Advances

Enabling sublingual peptide immunization with molecular self-assemblies

(2020) Sean H. Kelly et al.   BIOMATERIALS

Development of an Orodispersible Film Containing Stabilized Influenza Vaccine

(2020) Yu Tian et al.   Pharmaceutics

New GMP manufacturing processes to obtain thermostable HIV-1 gp41 virosomes under solid forms for various mucosal vaccination routes

(2020) Mario Amacker et al.   npj Vaccines

Shaping humoral immunity to vaccines through antigen-displaying nanoparticles

(2020) Darrell J Irvine et al.   CURRENT OPINION IN IMMUNOLOGY

Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations

(2020) Jacob T. Martin et al.   npj Vaccines

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation

(2020) Hannah G. Kelly et al.   JCI Insight

A crossover clinical study to evaluate pain intensity from microneedle insertion in different parts of the oral cavity

(2020) Stephany Di Carla Santos et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Altered chromatin landscape in circulating T follicular helper and regulatory cells following grass pollen subcutaneous and sublingual immunotherapy

(2020) Hanisah Sharif et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

(2019) Andrew T. Jones et al.   Nature Communications

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

(2019) Kimberly M. Cirelli et al.   CELL

Induction of mycobacterial protective immunity by sublingual BCG vaccination

(2019) Christopher S. Eickhoff et al.   VACCINE

Intradermal or sublingual delivery and heat-labile enterotoxin (LT) proteins shape immunologic outcomes to CFA/I fimbriae-derived subunit antigen vaccine against enterotoxigenic E. coli

(2019) Milton Maciel et al.   INFECTION AND IMMUNITY

Active immunoprophyilaxis with uromune® decreases the recurrence of urinary tract infections at three and six months after treatment without relevant secondary effects

(2019) Cristóbal Ramírez Sevilla et al.   BMC INFECTIOUS DISEASES

The power of saliva: Antimicrobial and beyond

(2019) Taissa Vila et al.   PLoS Pathogens

Adjuvants and delivery systems based on polymeric nanoparticles for mucosal vaccines

(2019) Zheng Jin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Enhancing immunogenicity of antigens through sustained intradermal delivery using chitosan microneedles with a patch-dissolvable design

(2018) Mei-Chin Chen et al.   Acta Biomaterialia

Mucosal and systemic immune response to sublingual or intranasal immunization with phosphorylcholine

(2018) Yoshiko Maseda et al.   AURIS NASUS LARYNX

Improving Vaccine and Immunotherapy Design Using Biomaterials

(2018) Michelle L. Bookstaver et al.   TRENDS IN IMMUNOLOGY

The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT

(2018) John D. Clements et al.   mSphere

A Phase 1 dose escalating study of double mutant heat-labile toxin LTR192G/L211A (dmLT) from Enterotoxigenic Escherichia coli (ETEC) by sublingual or oral immunization

(2018) David I. Bernstein et al.   VACCINE

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

(2017) Matthias Pauthner et al.   IMMUNITY

Multi-layered nanofibrous mucoadhesive films for buccal and sublingual administration of drug-delivery and vaccination nanoparticles - important step towards effective mucosal vaccines

(2017) Josef Mašek et al.   JOURNAL OF CONTROLLED RELEASE

An oral microjet vaccination system elicits antibody production in rabbits

(2017) Kiana Aran et al.   Science Translational Medicine

Sublingual targeting of STING with 3′3′-cGAMP promotes systemic and mucosal immunity against anthrax toxins

(2017) Tara L. Martin et al.   VACCINE

Sublingual Priming with a HIV gp41-Based Subunit Vaccine Elicits Mucosal Antibodies and Persistent B Memory Responses in Non-Human Primates

(2017) Selma Bekri et al.   Frontiers in Immunology

Deficiency in Calcium-Binding Protein S100A4 Impairs the Adjuvant Action of Cholera Toxin

(2017) Jia-Bin Sun et al.   Frontiers in Immunology

Mucosal Administration of Cycle-Di-Nucleotide-Adjuvanted Virosomes Efficiently Induces Protection against Influenza H5N1 in Mice

(2017) Thomas Ebensen et al.   Frontiers in Immunology

Comparative analysis of the oral mucosae from rodents and non-rodents: Application to the nonclinical evaluation of sublingual immunotherapy products

(2017) Catherine Thirion-Delalande et al.   PLoS One

Beyond antigens and adjuvants: formulating future vaccines

(2016) Tyson J. Moyer et al.   JOURNAL OF CLINICAL INVESTIGATION

PEG modified liposomes containing CRX-601 adjuvant in combination with methylglycol chitosan enhance the murine sublingual immune response to influenza vaccination

(2016) Hardeep S. Oberoi et al.   JOURNAL OF CONTROLLED RELEASE

CD71 targeting boosts immunogenicity of sublingually delivered influenza haemagglutinin antigen and protects against viral challenge in mice

(2016) Jamie F.S. Mann et al.   JOURNAL OF CONTROLLED RELEASE

Sublingual immunization with Japanese encephalitis virus vaccine effectively induces immunity through both cellular and humoral immune responses in mice

(2016) Eun-Young Lee et al.   MICROBIOLOGY AND IMMUNOLOGY

MV140, a sublingual polyvalent bacterial preparation to treat recurrent urinary tract infections, licenses human dendritic cells for generating Th1, Th17 and IL-10 responses via Syk and MyD88

(2016) C Benito-Villalvilla et al.   Mucosal Immunology

Modular virus-like particles for sublingual vaccination against group A streptococcus

(2016) Arjun Seth et al.   VACCINE

Sublingual injection of microparticles containing glycolipid ligands for NKT cells and subunit vaccines induces antibody responses in oral cavity

(2015) Elizabeth S. DeLyria et al.   CARBOHYDRATE RESEARCH

Transportation of sublingual antigens across sublingual ductal epithelial cells to the ductal antigen-presenting cells in mice

(2015) Y. Nagai et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Oral Immunization with Recombinant Vaccinia Virus Prime and Intramuscular Protein Boost Provides Protection against Intrarectal Simian-Human Immunodeficiency Virus Challenge in Macaques

(2015) Rajesh Thippeshappa et al.   Clinical and Vaccine Immunology

Methylglycol chitosan and a synthetic TLR4 agonist enhance immune responses to influenza vaccine administered sublingually

(2015) Justin L. Spinner et al.   VACCINE

Advances and challenges in mucosal adjuvant technology

(2015) Daniel Newsted et al.   VACCINE

Multifunctional liposomes constituting microneedles induced robust systemic and mucosal immunoresponses against the loaded antigens via oral mucosal vaccination

(2015) Yuanyuan Zhen et al.   VACCINE

Evaluation of mucosal adjuvants and immunization routes for the induction of systemic and mucosal humoral immune responses in macaques

(2015) Ronald S Veazey et al.   Human Vaccines & Immunotherapeutics

A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway

(2015) Masahiro Fukasaka et al.   PLoS One

Sublingual administration of a helper-dependent adenoviral vector expressing the codon-optimized soluble fusion glycoprotein of human respiratory syncytial virus elicits protective immunity in mice

(2014) Yuan-hui Fu et al.   ANTIVIRAL RESEARCH

Mannose derivative and lipid A dually decorated cationic liposomes as an effective cold chain free oral mucosal vaccine adjuvant-delivery system

(2014) Ning Wang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Polymeric penetration enhancers promote humoral immune responses to mucosal vaccines

(2014) Katja Klein et al.   JOURNAL OF CONTROLLED RELEASE

Buccal and sublingual vaccine delivery

(2014) Heleen Kraan et al.   JOURNAL OF CONTROLLED RELEASE

Microprojection arrays to immunise at mucosal surfaces

(2014) Celia L. McNeilly et al.   JOURNAL OF CONTROLLED RELEASE

Vaccine Delivery to the Oral Cavity Using Coated Microneedles Induces Systemic and Mucosal Immunity

(2014) Yunzhe Ma et al.   PHARMACEUTICAL RESEARCH

Enhancing the Buccal Mucosal Delivery of Peptide and Protein Therapeutics

(2014) Thiago Caon et al.   PHARMACEUTICAL RESEARCH

Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets

(2014) Chenyang Zhang et al.   VACCINE

Sublingual immunization with a subunit influenza vaccine elicits comparable systemic immune response as intramuscular immunization, but also induces local IgA and TH17 responses

(2014) Simona Gallorini et al.   VACCINE

Natural killer T cell and TLR9 agonists as mucosal adjuvants for sublingual vaccination with clade C HIV-1 envelope protein

(2014) Shailbala Singh et al.   VACCINE

Serum and mucosal antibody responses to inactivated polio vaccine after sublingual immunization using a thermoresponsive gel delivery system

(2014) Jessica A White et al.   Human Vaccines & Immunotherapeutics

TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens

(2014) Ryan McClure et al.   Frontiers in Immunology

Herd Protection by a Bivalent Killed Whole-Cell Oral Cholera Vaccine in the Slums of Kolkata, India

(2013) Mohammad Ali, Dipika Sur, Young Ae You, Suman Kanungo, Binod Sah, Byomkesh Manna, Mahesh Puri, Thomas F. Wierzba et al.   CLINICAL INFECTIOUS DISEASES

Antigen-bearing dendritic cells from the sublingual mucosa recirculate to distant systemic lymphoid organs to prime mucosal CD8 T cells

(2013) C Hervouet et al.   Mucosal Immunology

Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells

(2012) Ayako Inamine et al.   CLINICAL IMMUNOLOGY

Sublingual vaccination

(2011) Cecil Czerkinsky et al.   Human vaccines & immunotherapeutics

Evaluation of the Sublingual Route for Administration of Influenza H5N1 Virosomes in Combination with the Bacterial Second Messenger c-di-GMP

(2011) Gabriel Kristian Pedersen et al.   PLoS One

Immunological Effects of Sublingual Immunotherapy: Clinical Efficacy Is Associated with Modulation of Programmed Cell Death Ligand 1, IL-10, and IgG4

(2010) S. Piconi et al.   JOURNAL OF IMMUNOLOGY

Micro- and macrorheology of mucus

(2009) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

CCR7-CCL19/CCL21-Regulated Dendritic Cells Are Responsible for Effectiveness of Sublingual Vaccination

(2009) J.-H. Song et al.   JOURNAL OF IMMUNOLOGY

Sublingual Immunization with Nonreplicating Antigens Induces Antibody-Forming Cells and Cytotoxic T Cells in the Female Genital Tract Mucosa and Protects against Genital Papillomavirus Infection

(2009) N. Cuburu et al.   JOURNAL OF IMMUNOLOGY

Materials engineering for immunomodulation

(2009) Jeffrey A. Hubbell et al.   NATURE

Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4+ T cells

(2008) Laurent Mascarell et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mucins in the mucosal barrier to infection

(2008) S K Linden et al.   Mucosal Immunology

The immune privilege of the oral mucosa

(2008) Natalija Novak et al.   TRENDS IN MOLECULAR MEDICINE