Telmisartan prevents high-fat diet-induced neurovascular impairments and reduces anxiety-like behavior

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice

(2020) Jan Wenzel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnetic resonance assessment of the cerebral alterations associated with obesity development

(2020) Blanca Lizarbe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

(2020) Nathalie Percie du Sert et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

The obesity transition: stages of the global epidemic

(2019) Lindsay M Jaacks et al.   Lancet Diabetes & Endocrinology

The antiobese effect of AT1 receptor blockade is augmented in mice lacking Mas

(2019) Carla Dapper et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Telmisartan prevents development of obesity and normalizes hypothalamic lipid droplets

(2019) Elias Rawish et al.   JOURNAL OF ENDOCRINOLOGY

Telmisartan prevents diet-induced obesity and preserves leptin transport across the blood-brain barrier in high-fat diet-fed mice

(2018) Franziska Schuster et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome

(2017) Michael J Haley et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Short-term interval training alters brain glucose metabolism in subjects with insulin resistance

(2017) Sanna M Honkala et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain renin-angiotensin system in the pathophysiology of cardiovascular diseases

(2017) Gianna Huber et al.   PHARMACOLOGICAL RESEARCH

A Review of String Vessels or Collapsed, Empty Basement Membrane Tubes

(2017) William R. Brown   JOURNAL OF ALZHEIMERS DISEASE

The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies

(2016) Emilio Pedditizi et al.   AGE AND AGEING

The brain renin-angiotensin system plays a crucial role in regulating body weight in diet-induced obesity in rats

(2016) Martina Winkler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer’s Disease

(2016) Juan M. Saavedra   CELLULAR AND MOLECULAR NEUROBIOLOGY

Angiotensin II type 1 receptor antagonists in animal models of vascular, cardiac, metabolic and renal disease

(2016) Martin C. Michel et al.   PHARMACOLOGY & THERAPEUTICS

Brain endothelial TAK1 and NEMO safeguard the neurovascular unit

(2015) Dirk A. Ridder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling

(2015) Sharad S. Singhal et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Preventing leptin resistance by blocking angiotensin II AT1receptors in diet-induced obese rats

(2014) Helge Müller-Fielitz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cerebral Neovascularization in Diabetes: Implications for Stroke Recovery and beyond

(2014) Adviye Ergul et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early effects of high-fat diet on neurovascular function and focal ischemic brain injury

(2013) Weiguo Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Chronic blockade of angiotensin AT1receptors improves cardinal symptoms of metabolic syndrome in diet-induced obesity in rats

(2013) Helge Müller-Fielitz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

(2013) Eric C. Swanson et al.   JOURNAL OF CELL BIOLOGY

Spatial memory impairment and changes in hippocampal morphology are triggered by high-fat diets in adolescent mice. Is there a role of leptin?

(2013) Ismael Valladolid-Acebes et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Improved Insulin Sensitivity after Long-Term Treatment with AT1Blockers Is Not Associated with PPARγ Target Gene Regulation

(2012) Helge Müller-Fielitz et al.   ENDOCRINOLOGY

Juvenile, but not adult exposure to high-fat diet impairs relational memory and hippocampal neurogenesis in mice

(2012) Chloe Boitard et al.   HIPPOCAMPUS

Double blockade of angiotensin II (AT1)-receptors and ACE does not improve weight gain and glucose homeostasis better than single-drug treatments in obese rats

(2011) Anja Miesel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Telmisartan Improves Insulin Resistance and Modulates Adipose Tissue Macrophage Polarization in High-Fat-Fed Mice

(2011) Shiho Fujisaka et al.   ENDOCRINOLOGY

Inflammation, Oxidative Stress, and Obesity

(2011) Alba Fernández-Sánchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Weight loss and hypophagia after high-dose AT1-blockade is only observed after high dosing and depends on regular leptin signalling but not blood pressure

(2011) Helge Müller-Fielitz et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task

(2010) Alison D. McNeilly et al.   BEHAVIOURAL BRAIN RESEARCH

Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL/6 mice fed on a very high-fat diet

(2010) Vanessa Souza-Mello et al.   CLINICAL SCIENCE

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Obesity Increases Blood Pressure, Cerebral Vascular Remodeling, and Severity of Stroke in the Zucker Rat

(2008) Jessica M. Osmond et al.   HYPERTENSION