Spatiotemporal coordination of Greatwall-Endos-PP2A promotes mitotic progression

The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis

(2020) Xavier Bisteau et al.   ONCOGENE

PP2A-B55 Holoenzyme Regulation and Cancer

(2020) Perrine Goguet-Rubio et al.   Biomolecules

ENSA and ARPP19 differentially control cell cycle progression and development

(2019) Khaled Hached et al.   JOURNAL OF CELL BIOLOGY

Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP 1 and PP 2A

(2019) James Holder et al.   FEBS LETTERS

Greatwall-Endosulfine: A Molecular Switch that Regulates PP2A/B55 Protein Phosphatase Activity in Dividing and Quiescent Cells

(2019) Natalia García-Blanco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Assembly of Mitotic Structures through Phase Separation

(2018) Jeffrey B. Woodruff   JOURNAL OF MOLECULAR BIOLOGY

A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key

(2018) Lionel Pintard et al.   Open Biology

PP2A-B55 promotes nuclear envelope reformation after mitosis in Drosophila

(2018) Haytham Mehsen et al.   JOURNAL OF CELL BIOLOGY

Greatwall kinase at a glance

(2018) Anna Castro et al.   JOURNAL OF CELL SCIENCE

Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation

(2018) Changfu Yao et al.   PLoS One

Aurora A activation in mitosis promoted by BuGZ

(2017) Yuejia Huang et al.   JOURNAL OF CELL BIOLOGY

Ensa controls S-phase length by modulating Treslin levels

(2017) Sophie Charrasse et al.   Nature Communications

Mechanisms and Consequences of Macromolecular Phase Separation

(2016) Louis-Philippe Bergeron-Sandoval et al.   CELL

Spatial regulation of greatwall by Cdk1 and PP2A-Tws in the cell cycle

(2016) Peng Wang et al.   CELL CYCLE

A Role for the Twins Protein Phosphatase (PP2A-B55) in the Maintenance of Drosophila Genome Integrity

(2016) Chiara Merigliano et al.   GENETICS

A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit

(2016) Michael J. Cundell et al.   JOURNAL OF CELL BIOLOGY

Greatwall dephosphorylation and inactivation upon mitotic exit is triggered by PP1

(2016) Sheng Ma et al.   JOURNAL OF CELL SCIENCE

Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint

(2016) M. Kasim Diril et al.   PLoS Genetics

A Role for the Twins Protein Phosphatase (PP2A-B55) in the Maintenance of Drosophila Genome Integrity

(2016) Chiara Merigliano et al.   GENETICS

Protein phosphatase 1 is essential for Greatwall inactivation at mitotic exit

(2015) A. Heim et al.   EMBO REPORTS

Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry

(2014) Mónica Álvarez-Fernández et al.   BIOESSAYS

Regulation of Greatwall kinase by protein stabilization and nuclear localization

(2014) Tomomi M Yamamoto et al.   CELL CYCLE

The dynamic spindle matrix

(2014) Nina Schweizer et al.   CURRENT OPINION IN CELL BIOLOGY

Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers

(2014) Byron C Williams et al.   eLife

Regulation of α-endosulfine, an inhibitor of protein phosphatase 2A, by multisite phosphorylation

(2013) Satoru Mochida   FEBS Journal

Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression

(2013) Peng Wang et al.   JOURNAL OF CELL BIOLOGY

The BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation

(2013) Michael J. Cundell et al.   MOLECULAR CELL

Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals

(2013) M. Alvarez-Fernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Budding Yeast Greatwall and Endosulfines Control Activity and Spatial Regulation of PP2ACdc55 for Timely Mitotic Progression

(2013) Maria Angeles Juanes et al.   PLoS Genetics

Spatial Positive Feedback at the Onset of Mitosis

(2012) Silvia D.M. Santos et al.   CELL

Bypassing the Greatwall-Endosulfine Pathway: Plasticity of a Pivotal Cell-Cycle Regulatory Module in Drosophila melanogaster and Caenorhabditis elegans

(2012) M.-Y. Kim et al.   GENETICS

Determinants for Activation of the Atypical AGC Kinase Greatwall during M Phase Entry

(2012) K. A. Blake-Hodek et al.   MOLECULAR AND CELLULAR BIOLOGY

A nuclear-derived proteinaceous matrix embeds the microtubule spindle apparatus during mitosis

(2012) Changfu Yao et al.   MOLECULAR BIOLOGY OF THE CELL

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor

(2012) Masatoshi Hara et al.   Nature Communications

Do nuclear envelope and intranuclear proteins reorganize during mitosis to form an elastic, hydrogel-like spindle matrix?

(2011) Kristen M. Johansen et al.   CHROMOSOME RESEARCH

Suppression of Scant Identifies Endos as a Substrate of Greatwall Kinase and a Negative Regulator of Protein Phosphatase 2A in Mitosis

(2011) Hélène Rangone et al.   PLoS Genetics

PP2A-Twins Is Antagonized by Greatwall and Collaborates with Polo for Cell Cycle Progression and Centrosome Attachment to Nuclei in Drosophila Embryos

(2011) Peng Wang et al.   PLoS Genetics

MASTL is the human ortholog of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis

(2010) Erik Voets et al.   CELL CYCLE

Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis

(2010) Olivier Gavet et al.   DEVELOPMENTAL CELL

The spindle matrix through the cell cycle in Drosophila

(2010) Jorgen Johansen et al.   FLY

Activation of cyclin B1–Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis

(2010) Olivier Gavet et al.   JOURNAL OF CELL BIOLOGY

Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle

(2010) T. Lorca et al.   JOURNAL OF CELL SCIENCE

Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

(2010) Michael H. A. Schmitz et al.   NATURE CELL BIOLOGY

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

(2010) Andrew Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A

(2010) A. Gharbi-Ayachi et al.   SCIENCE

Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis

(2010) S. Mochida et al.   SCIENCE

The Nuclear Pore Complex and Nuclear Transport

(2010) S. R. Wente et al.   Cold Spring Harbor Perspectives in Biology

Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

(2009) Mar Carmena et al.   CURRENT OPINION IN CELL BIOLOGY

Greatwall maintains mitosis through regulation of PP2A

(2009) Suzanne Vigneron et al.   EMBO JOURNAL

Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts

(2009) Satoru Mochida et al.   EMBO JOURNAL

Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator

(2009) Mariana Lince-Faria et al.   JOURNAL OF CELL BIOLOGY

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

(2009) Arne Lindqvist et al.   JOURNAL OF CELL BIOLOGY

The M Phase Kinase Greatwall (Gwl) Promotes Inactivation of PP2A/B55δ, a Phosphatase Directed Against CDK Phosphosites

(2009) Priscila V. Castilho et al.   MOLECULAR BIOLOGY OF THE CELL

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane-Induced Folding of the cAMP-Regulated Phosphoprotein Endosulfine-α†

(2008) John M. Boettcher et al.   BIOCHEMISTRY

 -Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila

(2008) J. R. Von Stetina et al.   DEVELOPMENT

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

(2008) Yanhui Xu et al.   MOLECULAR CELL