Article
Medicine, Research & Experimental
Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Hon-Kan Yip
Summary: The study demonstrated that combined CsA and Mel were superior to either CsA or Mel alone in protecting the brain against ischemia-reperfusion injury. The combination treatment showed significant reductions in neuronal damage and various biomarkers expressions in both cell and animal experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Guang-Rui Chai, Shu Liu, Hong-Wei Yang, Xiao-Long Chen
Summary: Quercetin has therapeutic effects in diabetic retinopathy by increasing retinal cell layer thickness, inhibiting overexpression of inflammatory factors, regulating the expression of angiogenic and neurotrophic factors, and possibly inducing heme oxygenase-1 expression.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rajesh Kumar Goit, Tsz Chung Ng, Ka Cheung Tam, Jessica K. W. Tsang, Andrew W. Taylor, Amy C. Y. Lo
Summary: alpha-Melanocyte-stimulating hormone (alpha-MSH) has neuroprotective effects against ischemia/reperfusion (I/R) induced brain damage in experimental stroke associated with hyperglycemia, reducing neuron death, inflammation, and oxidative stress. The use of alpha-MSH analogues may be a potential therapeutic strategy for diabetic stroke.
NEUROCHEMICAL RESEARCH
(2022)
Article
Cell Biology
Jing Zhang, Xia Cai, Qin Zhang, Xiaozhong Li, Siyuan Li, Jianyong Ma, Wengen Zhu, Xiao Liu, Meilin Wei, Wei Tu, Yunfeng Shen, Jianping Liu, Xiaoyang Lai, Peng Yu
Summary: The study found that hydrogen sulfide can restore the cardioprotection induced by sevoflurane postconditioning in diabetic rats by enhancing and promoting the SIRT1/Nrf2 signaling pathway, thereby mediating mitochondrial dysfunction and oxidative stress.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Ting Guo, Manli Chen, Ji Liu, Zengyu Wei, Jinjin Yuan, Wenwen Wu, Zhiyun Wu, Yongxing Lai, Zijun Zhao, Hongbin Chen, Nan Liu
Summary: Available literature suggests that ischemic stroke can disrupt mitochondrial morphology and function, but it is unknown whether NRP-1 can repair mitochondrial structure after cerebral ischemia. This study showed that NRP-1 can promote mitochondrial structural repair and functional recovery by activating the Wnt/beta-catenin signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jin Yu, Hong Zhu, Mark S. Kindy, Saeid Taheri
Summary: This study demonstrates that suppression of CYP2E1 can alleviate I/R injury and protect BBB integrity by reducing oxidative stress and inflammation. CYP2E1 KO mice showed lower lesion volume and neurological deficits after I/R, with decreased oxidative stress and inflammatory responses.
Article
Biochemistry & Molecular Biology
Dalia O. Saleh, Maha Nasr, Azza Hassan, Sally A. El-Awdan, Gehad A. Abdel Jaleel
Summary: The aim of this study was to investigate the therapeutic effects of curcumin nanoemulsion (NC) on cerebral damage in diabetic rats. The results showed that NC treatment reduced neurological deficit and redox imbalance, decreased inflammation and apoptosis, and restored glucose transporter 1 expression in the brain.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
Summary: The study demonstrated that allicin exerts a protective effect against renal ischemia/reperfusion injury in rats by regulating apoptosis, oxidative stress, and inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Nutrition & Dietetics
Douglas Ikedo Machado, Eloiza de Oliveira Silva, Sara Ventura, Maria de Fatima Fernandes Vattimo
Summary: Chronic kidney disease (CKD) and acute kidney injury (AKI) are global health problems that affect over 850 million people. Diabetes mellitus (DM) increases the susceptibility to AKI. Curcumin has shown positive effects in diabetic rats with AKI, improving renal function and reducing oxidative stress.
Letter
Neurosciences
Shitao Lv, Haiyan Yang, Pengcheng Jing, Haiying Song
Summary: Alpha-tocopherol has shown antioxidant, anti-inflammatory, and anti-apoptotic abilities in rat brain tissue, mitigating nerve damage caused by cerebral ischemia-reperfusion injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Safwen Kadri, Mohamed El Ayed, Amal Kadri, Ferid Limam, Ezzedine Aouani, Meherzia Mokni
Summary: Recent studies have shown that the combination of orlistat and grape seed extract can provide robust neuroprotection against brain ischemic injury, by correcting oxidative stress, metabolic pathway disturbances, and neuroinflammation induced by ischemic stroke.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Wen An, Ju-Seop Kang
Summary: Metformin can alleviate hepatic and myocardial injury induced by hepatic ischemia-reperfusion by inhibiting oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eyup Sari, Dilek Dilli, Irfan Tasoglu, Hasan Akduman, Nihat Yumusak, Naim Boran Tumer, Salih Salar
Summary: Melatonin and spirulina have protective effects against multiorgan damage induced by ischemia/reperfusion injury in a rat model, reducing oxidative tissue damage and apoptosis. Their antioxidant properties contribute to increasing total antioxidant capacity and reducing oxidative stress index, myeloperoxidase, tumor necrosis factor-alfa, and malondialdehyde levels.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Hanan Saleh, Mohamed Salama, Rehab Mohamed Hussein
Summary: This study investigated the protective effect of polyethylene glycol capped gold nanoparticles (PEG-AuNPs) on renal ischemia-reperfusion injury (I/R)-induced acute kidney injury (AKI) in diabetic mice by activating the AMPK-Nrf2 pathway. Results showed that PEG-AuNPs reduced blood urea nitrogen (BUN) and creatinine levels in diabetic mice and decreased renal damage and inflammation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Jacqueline Cavalcante Silva, Margherita Bavestrello, Valerio Gazzola, Giovanni Spinella, Bianca Pane, Elena Grasselli, Ilaria Demori, Laura Canesi, Laura Emionite, Michele Cilli, Ambra Buschiazzo, Gianmario Sambuceti, Ivan Rocha Pitta, Marina Galdino Pitta, Patrizia Perego, Domenico Palombo, Dulcineia Saes Parra Abdalla
Summary: I/R damage is a major challenge in cardiothoracic surgeries, characterized by exacerbated damage signals resulting from blood supply restriction and subsequent flow restoration. Inflammation and oxidative stress play important roles in I/R damage. This study suggests that the PPAR agonist GQ-11 could be a promising agent to prevent tissue dysfunction and death after cardiothoracic surgeries.
Article
Pharmacology & Pharmacy
Jiapeng Li, Xiaojun Huang, Qian Wang, Shan Jing, Hao Jiang, Zhongna Wei, Yannan Zang, Yang Liu, Libo Zhao, Yi Fang, Wanyu Feng
CLINICAL THERAPEUTICS
(2015)
Article
Chemistry, Medicinal
Daoli Jiang, Yitong Wang, Yannan Zang, Xiaofang Liu, Libo Zhao, Qian Wang, Chang Liu, Wanyu Feng, Xiaoxing Yin, Yi Fang
DRUG DEVELOPMENT RESEARCH
(2016)
Article
Multidisciplinary Sciences
Rongjing Song, Hepu Lin, Yue Chen, Xiuying Zhang, Wanyu Feng
Article
Pharmacology & Pharmacy
Xingxian Luo, Taifeng Li, Ze Yu, Xuecai Xue, Haiyang Zhao, Na Ii, Liping Ma, Changqing Yang, Lin Huang, Wanyu Feng
Article
Biochemical Research Methods
Yi Liu, Na Li, Liping Ma, Lin Huang, Shan Jing, Libo Zhao, Wanyu Feng
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
(2014)
Article
Urology & Nephrology
Chen Liu, Suying Yan, Yuqin Wang, Jinwei Wang, Xiujuan Fu, Hongtao Song, Rongsheng Tong, Mei Dong, Weihong Ge, Jiawei Wang, Hui Yang, Changlian Wang, Peiyuan Xia, Limei Zhao, Sijing Shen, Juan Xie, Yangui Xu, Peizhi Ma, Hongjian Li, Shegui Lu, Yufeng Ding, Ling Jiang, Yang Lin, Maoyi Wang, Feng Qiu, Wanyu Feng, Li Yang
Summary: This study investigated the disease burden, related drugs, and risk factors of D-AKI in China, revealing a substantial medical burden associated with D-AKI, with a high mortality rate and low recovery rate among patients. Efforts should be made to manage nephrotoxic drugs and improve prevention, diagnosis, and treatment of D-AKI.
Article
Pharmacology & Pharmacy
Han Yao, Xingxian Luo, Hong Zhang, Haiyan An, Wanyu Feng, Yi Feng
Summary: The distribution of R (-) - and S (+) - flurbiprofen in plasma and CSF differed significantly with R (-) - flurbiprofen showing lower penetration into the CNS compared to S (+) - flurbiprofen. Positive correlation was found between R (-) - and S (+) - flurbiprofen concentration in plasma and CSF, and negative correlation between plasma and CSF concentration of S (+) - flurbiprofen.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.