Review
Cell Biology
Tianmiao Ma, Bernhard W. Renz, Matthias Ilmer, Dominik Koch, Yuhui Yang, Jens Werner, Alexandr V. Bazhin
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment (TME) and have been linked to poor prognosis and drug resistance in cancer. Further research is needed to fully understand the definition and phenotypes of MDSCs in humans.
Review
Oncology
Shifen Wang, Xingyun Zhao, Siwen Wu, Dawei Cui, Zhenshu Xu
Summary: In this review, the biological functions, phenotypic characteristics, suppressive mechanisms, and expansion of MDSC populations in various types of hematological malignancies are summarized. The clinical correlation between MDSCs and the diagnosis of malignant hematological diseases, as well as the drugs targeting MDSCs, are discussed. Furthermore, the therapeutic strategies combining MDSCs targeting with other immunotherapies, such as immune checkpoint inhibitors, are highlighted.
BIOMARKER RESEARCH
(2023)
Review
Pathology
Lingfei Li, Mingyang Li, Qingge Jia
Summary: Myeloid-derived suppressor cell (MDSC) mainly exists in tumor microenvironment (TME) and interferes with normal immune response of the body. These immature differentiated cells cooperate with tumor cells for immune escape and proliferation. The subtypes of MDSC are different in different organisms, and STAT become a high priority for the signaling pathway mediating the regulation of MDSC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Aixia Dou, Jing Fang
Summary: Myeloid cells play a crucial role in tumor development, with pro-tumor and anti-tumor functions that impact tumor cells, tumor microenvironment, and immune system.
Review
Medicine, Research & Experimental
Feyza Gul Ozbay Kurt, Samantha Lasser, Ihor Arkhypov, Jochen Utikal, Viktor Umansky
Summary: Despite the success of immune checkpoint inhibitors in melanoma treatment, resistance to them remains a challenge. Myeloid-derived suppressor cells play a crucial role in ICI resistance and creating an immunosuppressive tumor microenvironment. Targeting MDSCs is considered a promising strategy to improve melanoma immunotherapy, and this review discusses the mechanism, studies, and potential strategies for inhibiting MDSC functions.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Oncology
Sitaram Harihar, Danny R. Welch
Summary: Current therapeutic approaches for metastatic cancers are ineffective at targeting dormant tumor cells, which are non-proliferative, growth-arrested, or resistant to therapy. The understanding of tumor dormancy has been limited, hindering progress in developing effective approaches. However, recent studies have identified KISS1 as a metastasis suppressor gene that keeps tumor cells in a dormant state. This review explores the mechanisms and potential application of KISS1 as a therapeutic for metastatic cancers by eliminating quiescent cells or inducing long-term dormancy.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Yuze Wu, Ming Yi, Mengke Niu, Qi Mei, Kongming Wu
Summary: This review focuses on the classification and inhibitory function of myeloid-derived suppressor cells (MDSCs) in immune checkpoint inhibitor (ICI) therapy, as well as the crosstalk between MDSCs and other myeloid cells. Recent findings suggest that targeting MDSCs may be a promising approach to enhance the efficacy of cancer immunotherapy.
Article
Oncology
Sara A. Vayrynen, Jinming Zhang, Chen Yuan, Juha P. Vayrynen, Andressa Dias Costa, Hannah Williams, Vicente Morales-Oyarvide, Mai Chan Lau, Douglas A. Rubinson, Richard F. Dunne, Margaret M. Kozak, Wenjia Wang, Diana Agostini-Vulaj, Michael G. Drage, Lauren Brais, Emma Reilly, Osama Rahma, Thomas Clancy, Jiping Wang, David C. Linehan, Andrew J. Aguirre, Charles S. Fuchs, Lisa M. Coussens, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, Shuji Ogino, Jonathan A. Nowak, Brian M. Wolpin
Summary: The study revealed a diverse set of myeloid cells within the PDAC tumor microenvironment, which are distributed heterogeneously across patient tumors. Beyond cell density, the spatial locations of immune cells are also associated with patient outcomes, underscoring the potential role of spatially resolved myeloid cell subtypes as quantitative biomarkers for PDAC prognosis and therapy.
CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Yijun Wang, Tongyue Zhang, Mengyu Sun, Xiaoyu Ji, Meng Xie, Wenjie Huang, Limin Xia
Summary: Myeloid-derived suppressor cells (MDSCs) hinder T cell infiltration into tumor sites, restricting the effectiveness of immune checkpoint inhibitors for certain patients, while targeting MDSCs has shown potent inhibitory effects in multiple tumors, including hepatocellular carcinoma. Clinically, the frequency of MDSCs is closely linked to the prognosis and predictive biomarkers of HCC patients, as well as the effectiveness of immune checkpoint inhibitors and tyrosine kinase inhibitors.
Review
Immunology
Alberto Mantovani, Federica Marchesi, Sebastien Jaillon, Cecilia Garlanda, Paola Allavena
Summary: Myeloid cells in tumor tissues, including tumor-associated macrophages and tumor-associated neutrophils, play crucial roles in tumor growth and invasion. In recent years, successful therapeutic approaches have been developed and tested in preclinical cancer models, with some strategies reaching clinical trials.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
RamaRao Malla, Lalitha Pappu, Krishna Chaitanya Amajala, Mohammad Amjad Kamal
Summary: This review provides a comprehensive analysis of the effectiveness of natural products in targeting MDSCs in the tumor immune microenvironment, supported by in silico experimental data. The combination of bioinformatics and wet bench experimentation shows promise in mitigating cancer.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Huanhuan Chen, Keqing Yang, Lingxiao Pang, Jing Fei, Yongliang Zhu, Jianwei Zhou
Summary: This study identified a novel protein, ANKRD22, involved in regulating the immunosuppressive ability of PMN-MDSCs. It was found that ANKRD22 levels were associated with the clinical characteristics and prognosis of ovarian cancer patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Pharmacology & Pharmacy
Yi Xiao, Dihua Yu
Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Oncology
Ihor Arkhypov, Feyza Gul Ozbay Kurt, Rebekka Bitsch, Daniel Novak, Vera Petrova, Samantha Lasser, Thomas Hielscher, Christopher Groth, Alisa Lepper, Xiaoying Hu, Wei Li, Jochen Utikal, Peter Altevogt, Viktor Umansky
Summary: Soluble HSP90 alpha can convert monocytes into MDSC, which inhibits the antitumor function of T and NK cells. Higher levels of HSP90 alpha in plasma of patients with melanoma are associated with increased PD-L1 expression on MDSC and shorter PFS after ICI therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Amrutha Menon, Noraini Abd-Aziz, Kanwal Khalid, Chit Laa Poh, Rakesh Naidu
Summary: This review focuses on the role of miRNA in cancer, therapeutic approaches with miRNAs, and effective delivery into the system. Patents and ongoing clinical trials for miRNA therapy are also summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Yoshiaki Mitsutake, Akihide Konishi, Takeshi Shiba, Takuya Ito, Mami Ho, Haruki Shirato
Summary: A drug-coated balloon catheter for coronary in-stent restenosis treatment was approved in Japan in 2013. Differences were found between pre-marketing study and post-marketing surveillance regarding lesion complexity and target lesion revascularization rates. DES-ISR was identified as a risk factor for TLR after DCB treatment for ISR.
Article
Chemistry, Analytical
Kanako Nakajima, Kazuko Hamada, Ryoga Ito, Yukina Yoshida, Kenneth Sutherland, Masayori Ishikawa, Michitaka Ozaki, Hiroki Shirato, Toshiyuki Hamada
Summary: Monitoring the circadian rhythm of clock gene expression is crucial for studying diseases like obesity, cancer, and sleep disorders, with research indicating that the detection of d-luciferin in living animals should be done within 7 days.
Article
Engineering, Biomedical
Sara Takahashi, Kiyotaka Iwasaki, Haruki Shirato, Mami Ho, Mitsuo Umezu
Summary: Our study revealed that both Japan and the United States have implemented similar policies to support the development of pediatric medical devices. Future efforts should focus on expediting the review process for regulatory approval, global development, and alternative measures to ensure device efficacy and safety through cooperation among industry, government, and academia.
JOURNAL OF ARTIFICIAL ORGANS
(2021)
Article
Biochemistry & Molecular Biology
Yu-Hung Lee, Ching-Fang Yu, Ying-Chieh Yang, Ji-Hong Hong, Chi-Shiun Chiang
Summary: The study found that ablative RT is more effective at recruiting T cells compared to fractionated RT, while fractionated RT leads to more myeloid-derived suppressor cell infiltration. The RT-disturbed TME has a higher perfusion rate, allowing more anti-PD-L1 antibody to reach the tumor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ching-Fang Yu, Chun-Hsiang Chang, Chun-Chieh Wang, Ji-Hong Hong, Chi-Shiun Chiang, Fang-Hsin Chen
Summary: The combination of radiation therapy and local IL-12 therapy enhances the host immune response, promotes vascular maturation and function, and is associated with less systemic toxicity compared to IL-12 therapy alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wen-Jen Lin, Pei-Chun Shen, Hsiu-Cheng Liu, Yi-Chun Cho, Min-Kung Hsu, I-Chen Lin, Fang-Hsin Chen, Juan-Cheng Yang, Wen-Lung Ma, Wei-Chung Cheng
Summary: LipidSig is a flexible and user-friendly web server designed to help users identify significant lipid-related features and advance the field of lipid biology through efficient data analysis and exploration of lipid characteristics.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Oncology
Chun-Chieh Chan, Fang-Hsin Chen, Ya-Yun Hsiao
Summary: The study proposes an algorithm to estimate the relative biological effectiveness (RBE) of proton beams for cell survival under different oxygen conditions, with RBE values varying with linear energy transfer (LET) ranges. The RBE values under severe hypoxia are higher, indicating a greater contribution of direct effects from protons.
Article
Biochemistry & Molecular Biology
Ying-Chieh Lai, Ching-Yi Hsieh, Kuan-Ying Lu, Cheng-Hsuan Sung, Hung-Yao Ho, Mei-Ling Cheng, Albert P. Chen, Shu-Hang Ng, Fang-Hsin Chen, Gigin Lin
Summary: The study utilized a new imaging technique, DNP C-13-MRI, to explore the metabolic effects of radiation on cancer cells and immune cells. The results showed significant changes in glycolytic flux rates in different types of cells after irradiation, suggesting the potential clinical utility of DNP C-13-MRI for future treatments.
Article
Cardiac & Cardiovascular Systems
Shin Iwamoto, Moe Ohashi, Haruki Shirato, Mami Ho, Misti Malone, Kenneth Cavanaugh
Summary: Regulatory approval processes for medical devices in Japan and the United States often require similar clinical trials. The Harmonization by Doing (HBD) program facilitates communication between regulators, academics, and industry, supporting the design and conduct of US/Japanese clinical trials for approval in both countries.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ya-Yun Hsiao, Fang-Hsin Chen, Chun-Chieh Chan, Ching-Chih Tsai
Summary: This study estimated the yields of DNA double-strand breaks (DSBs) induced by ultrasoft X-rays, evaluated their relative biological effectiveness (RBE) and repair outcomes, and compared them to Co-60 gamma-rays. The results showed higher RBE values for ultrasoft X-rays under different conditions, indicating a potential advantage in cancer treatment through the synergistic effects of DSB induction and enzymatic DSB formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Min Gao, Hsien-Hsin Chen, Fang-Hsin Chen, Ji-Hong Hong, Ing-Tsung Hsiao, Tzu-Chen Yen, Jingfang Mao, Jiade J. Lu, Weidong Wang, Nicola D'Ascenzo, Qingguo Xie
Summary: The novel all-digital PET dual heads prototype utilizing MVT technology demonstrates the ability to monitor proton tracks within biological tissues in beam-on mode. Experimental results show that the system is capable of imaging the induced activity by proton beams with energy ranging between 70 and 150 MeV during irradiation.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2021)
Article
Oncology
Chun-Chieh Chan, Fang-Hsin Chen, Kuang-Lung Hsueh, Ya-Yun Hsiao
Summary: This study calculates the relative biological effectiveness (RBE) and oxygen enhancement ratio (OER) for DNA double-strand break (DSB) induction and cell survival under hypoxic conditions for Grenz-ray therapy (GT). The results show that GT can cause more DSB induction and effectively control superficial and hypoxic tumors.
Article
Engineering, Biomedical
Naresh Kuthala, Munusamy Shanmugam, Chao-Lang Yao, Chi-Shim Chiang, Kuo Chu Hwang
Summary: A new boron neutron capture therapy (BNCT) reagent, anti-EGFR-10BPO4 NPs, was developed in this study with the ability to target head and neck cancer cells. In both in vivo and in vitro experiments, anti-EGFR-10BPO4 NPs showed significant improvement in destroying head and neck tumors, effectively suppressing recurrence, and demonstrated better survival rates.
Article
Cardiac & Cardiovascular Systems
Ryo Inuzuka, Hisateru Tachimori, Sung-Hae Kim, Hikoro Matsui, Tohru Kobayashi, Atsuko Kato, Takanari Fujii, Mami Ho, Hanako Morikawa, Sara Takahashi, Haruki Shirato, Yuji Haishima, Yoshihiro Okamoto, Hideyuki Sakoda, Hideshi Tomita
Summary: This study revealed differences in patient background between static and pull-through BAS, as well as a higher incidence of adverse events related to static BAS. Patients weighing <3 kg are at high risk for adverse events after static BAS.
CIRCULATION JOURNAL
(2022)
Article
Chemistry, Physical
Naresh Kuthala, Munusamy Shanmugam, Xiangyi Kong, Chi-Shiun Chiang, Kuo Chu Hwang
Summary: This study focuses on the synthesis and optimization of core-gap-shell nanostructures to enhance the optical properties of dye molecules. By filling the nanogap with a high dielectric NaCl(aq) aqueous solution, the researchers were able to significantly increase the plasmonic field-field coupling and enhance the therapeutic effects of the nanomaterials on murine colon tumors. This work presents a new method to maximize the plasmonic field-field and field-lattice coupling in nanogap-based bioimaging, sensing, and theranostic nanomaterials and devices.
NANOSCALE HORIZONS
(2022)