Article
Urology & Nephrology
Jeffrey A. Sparks, Kathleen M. M. Vanni, Matthew A. Sparks, Chang Xu, Leah M. Santacroce, Robert J. Glynn, Paul M. Ridker, Daniel H. Solomon
Summary: The study demonstrates the kidney safety of low-dose methotrexate in patients with normal kidney function or mild-to-moderate CKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Renate Viebahn-Haensler, Olga Sonia Leon Fernandez
Summary: Low-dose ozone can act as a bioregulator in chronic inflammatory diseases by improving oxidative stress and redox signaling. It works through two mechanisms: direct for topical treatments and indirect for systemic treatments, providing potential benefits in regulating antioxidants and modulating cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Alexander F. Haddad, Jacob S. Young, Jun Yeop Oh, Hideho Okada, Manish K. Aghi
Summary: This review discusses relevant research on the LGG tumor immune microenvironment, including immune cell infiltration, tumor immunogenicity, checkpoint molecule expression, the impact of an IDH mutation, and implications for immunotherapies.
NEUROSURGICAL FOCUS
(2022)
Article
Medicine, Research & Experimental
Daniel B. Yidana
Summary: HS is a chronic, recurrent skin disease with complex pathophysiology possibly related to immune system dysregulation, and IL-17 may be a common factor linking HS with other immune-mediated diseases. Further exploration into the role of fungi and aryl hydrocarbon receptor in HS pathogenesis is needed.
MEDICAL HYPOTHESES
(2021)
Review
Biochemistry & Molecular Biology
Francesca Parisi, Roberta Milazzo, Valeria M. Savasi, Irene Cetin
Summary: Overweight and obesity during pregnancy can lead to increased birth weight, childhood obesity, and noncommunicable diseases in the offspring, perpetuating metabolic derangements across generations. The key components in intrauterine developmental programming are still to be identified, and inflammation may induce intrauterine derangements with a threshold effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Rachel Shvartsur, Galila Agam, Sarit Uzzan, Abed N. Azab
Summary: Mounting evidence suggests that immune-system dysfunction and inflammation play a role in the pathophysiology and treatment of mood disorders. This study found that chronic combined treatment attenuated LPS-induced hypothermia and reduced cytokine levels, suggesting a potential approach for treating inflammation-related mental illness. The treatment also showed antidepressant-like effects.
Article
Medicine, Research & Experimental
Dominik Sonanini, Christoph M. Griessinger, Barbara F. Schoerg, Philipp Knopf, Klaus Dittmann, Martin Roecken, Bernd J. Pichler, Manfred Kneilling
Summary: The study demonstrated that low-dose TBI can significantly improve the efficacy of CD4+ T cell-based immunotherapies, leading to increased survival of RIP1-Tag2 mice and enhanced infiltration of CD4+ T cells in tumor tissue. This approach may provide a rationale for combining TBI with immunotherapy for cancer treatment in clinical settings.
Review
Food Science & Technology
Luigi Barrea, Massimiliano Caprio, Mikiko Watanabe, Giuseppe Cammarata, Alessandra Feraco, Giovanna Muscogiuri, Ludovica Verde, Annamaria Colao, Silvia Savastano
Summary: Obesity is an emerging non-communicable disease associated with chronic low-grade inflammation and oxidative stress. The ketogenic diet (KD), characterized by high fat intake, moderate to low protein consumption, and very low carbohydrate intake, has proven to be effective in weight loss and improving the inflammatory state and oxidative stress in individuals with obesity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Ewa Rudnicka, Katarzyna Suchta, Monika Grymowicz, Anna Calik-Ksepka, Katarzyna Smolarczyk, Anna M. Duszewska, Roman Smolarczyk, Blazej Meczekalski
Summary: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology, often leading to health issues like obesity and insulin resistance. Studies suggest a link between PCOS and chronic inflammation, which may contribute to cardiovascular diseases and other complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Benjamin Maier, Amy S. Tsai, Jakob F. Einhaus, Jean-Philippe Desilles, Benoit Ho-Tin-Noe, Benjamin Gory, Marina Sirota, Richard Leigh, Robin Lemmens, Gregory Albers, Jean-Marc Olivot, Mikael Mazighi, Brice Gaudilliere
Summary: Ischemic stroke is the primary cause of acquired disability and the second cause of dementia and mortality. Current treatments are focused on revascularization, but have limited success. The neuro- and thrombo-inflammatory response after stroke plays a significant role in outcomes, but previous clinical trials on immunosuppressive drugs have failed. Understanding the inter-patient variability in the inflammatory response is crucial in translating preclinical findings.
SEMINARS IN IMMUNOPATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Stephen Perry, Mark S. Kindy
Summary: Plant-based nutritional supplementation can attenuate the progression of acute and chronic disorders by improving inflammatory responses and maintaining stable neurotransmitter levels. Experimentally induced inflammation by LPS affects glucose, insulin tolerance, and neurotransmitter levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Ilaria Demori, Elena Molinari, Fabio Rapallo, Viviana Mucci, Lucio Marinelli, Serena Losacco, Bruno Burlando
Summary: Fibromyalgia is a chronic pain syndrome with unclear causes, characterized by pain and various other symptoms. This study found that FM patients responded better to non-pharmacological therapies, suggesting that they should be considered in conjunction with drug treatments.
Article
Pharmacology & Pharmacy
Rachel Shvartsur, Galila Agam, Alla Shnaider, Sarit Uzzan, Ahmad Nassar, Adi Jabarin, Naim Abu-Freha, Karen Meir, Abed N. Azab
Summary: Chronic low-dose aspirin can mitigate the typical renal side effects of standard-dose lithium and enhance the beneficial behavioral effects of low-dose lithium therapy without aggravating its toxicity.
Review
Environmental Sciences
Paola Gonzalo-Encabo, Gonzalo Maldonado, David Valades, Carmen Ferragut, Alberto Perez-Lopez
Summary: Low-grade systemic inflammation can lead to non-communicable diseases, especially in adults with obesity. Exercise training has been shown to reduce this inflammation, with aerobic training decreasing CRP, IL-6, and TNF-alpha levels, and resistance training also having an impact on cytokine levels. Changes in cytokines are associated with fat mass reduction, suggesting that exercise-induced fat loss may mediate the effects on inflammation in adults with overweight and obesity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Pharmacology & Pharmacy
Adrian Dervan, Antonio Franchi, Francisco R. Almeida-Gonzalez, Jennifer K. Dowling, Ohemaa B. Kwakyi, Claire E. McCoy, Fergal J. O'Brien, Alan Hibbitts
Summary: Injuries to the nervous system often lead to loss of motor and sensory function, with macrophage infiltration playing a crucial role in the inflammatory response and tissue repair. Recent developments have focused on using biomaterial implants to create a growth-inductive environment for axon regeneration and modulate macrophage phenotype towards a pro-repair state. The intersection of these two areas of research has resulted in the creation of 'immune-modulatory' biomaterials aimed at enhancing tissue repair following nervous tissue injury.
Article
Physics, Mathematical
Massimo Fioranelli, Alireza Sepehri
INTERNATIONAL JOURNAL OF GEOMETRIC METHODS IN MODERN PHYSICS
(2018)
Review
Immunology
Massimo Fioranelli, Anna G. Bottaccioli, Francesco Bottaccioli, Maria Bianchi, Miriam Rovesti, Maria G. Roccia
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Physics, Multidisciplinary
Alireza Sepehri, Massimo Fioranelli
Article
Physics, Mathematical
Massimo Fioranelli, Maria Grazia Roccia
INTERNATIONAL JOURNAL OF GEOMETRIC METHODS IN MODERN PHYSICS
(2019)
Article
Physics, Multidisciplinary
Alireza Sepehri, Massimo Fioranelli, Maria Grazia Roccia, Somayyeh Shoorvazi
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2019)
Article
Dermatology
Torello Lotti, Michael Tirant, A. Rateb Said, Bogdan Morad Albzour, Mariangela Santiago, Manjula Agrawal, Ash Dutta, Van Thuong Nguyen, Mary Vadala, B. Palmieri, Aleksandra Vojvodic, Massimo Fioranelli
DERMATOLOGIC THERAPY
(2020)
Article
Physics, Multidisciplinary
Massimo Fioranelli, Alireza Sepehri, Maria Grazia Roccia, Mahdieh Ghasemi
Article
Dermatology
Massimo Fioranelli, Mohammad Jafferany, Uwe Wollina, Michael Tirant, Nguyen Van Thuong, Torello Lotti
DERMATOLOGIC THERAPY
(2020)
Article
Dermatology
Massimo Fioranelli, Alireza Sepehri, Maria Grazia Roccia, Aracena Jahaira Carolina, Iva Binic, Masa Golubovic, Michael Tirant, Nguyen Van Thuong, Julia Sigova, Torello Lotti, Aroonkumar Beesham
DERMATOLOGIC THERAPY
(2020)
Article
Dermatology
Uwe Wollina, Massimo Fioranelli, Mohamad Goldust, Torello Lotti
DERMATOLOGIC THERAPY
(2020)
Article
Medicine, General & Internal
Marco Paoloni, Francesco Agostini, Sergio Bernasconi, Gianni Bona, Carlo Cisari, Massimo Fioranelli, Marco Invernizzi, Antonello Madeo, Marco Matucci-Cerinic, Alberto Migliore, Nicola Quirino, Carlo Ventura, Roberto Vigano, Andrea Bernetti
Summary: This paper conducted a Delphi consensus to investigate the opinions of Italian physicians on the use of CAM in clinical practice. The results showed consensus on various topics, including indications and safety issues. The conclusion is that combining CAM with conventional medicines is safe for treating non-critical medical conditions.
MEDICINA-LITHUANIA
(2022)
Article
Physics, Applied
Alireza Sepehri, Massimo Fioranelli, Maria Grazia Roccia, Somayyeh Shoorvazi
JOURNAL OF THEORETICAL AND APPLIED PHYSICS
(2019)
Article
Medicine, General & Internal
Massimo Fioranelli, Maria Grazia Roccia, Miriam Rovesti, Francesca Satolli, Paola Petrelli, Claudio Feliciani, Torello Lotti
WIENER MEDIZINISCHE WOCHENSCHRIFT
(2017)
Article
Cardiac & Cardiovascular Systems
Giuseppe Tarantini, Giovanni Esposito, Giuseppe Musumeci, Chiara Fraccaro, Anna Franzone, Battistina Castiglioni, Alessio La Manna, Ugo Limbruno, Alfredo Marchese, Ciro Mauro, Stefano Rigattieri, Fabio Tarantino, Caterina Gandolfo, Gennaro Santoro, Roberto Violini, Flavio Airoldi, Remo Albiero, Manrico Balbi, Giorgio Baralis, Antonio Luca Bartorelli, Francesco Bedogni, Alberto Benassi, Andrea Berni, Giulio Bonzani, Alessandro Santo Bortone, Giuseppe Braito, Carlo Briguori, Elvis Brscic, Paolo Calabro, Ivan Calchera, Maurizio Cappelli Bigazzi, Francesco Caprioglio, Fausto Castriota, Carlo Cernetti, Cinzia Cicala, Paolo Cioffi, Antonio Colombo, Virgilio Colombo, Gaetano Contegiacomo, Alberto Cremonesi, Maurizio D'Amico, Mauro De Benedictis, Alessandro De Leo, Maurizio Di Biasi, Domenico Di Girolamo, Emilio Di Lorenzo, Carlo Di Mario, Marcello Dominici, Federica Ettori, Maurizio Ferrario, Massimo Fioranelli, Dionigi Fischetti, Gabriele Gabrielli, Arturo Giordano, Pietro Giudice, Cesare Greco, Ciro Indolfi, Ornella Leonzi, Corrado Lettieri, Bruno Loi, Nicola Maddestra, Niccolo Marchionni, Cinzia Marrozzini, Massimo Medda, Bindo Missiroli, Luigi My, Jacopo Andrea Oreglia, Cataldo Palmieri, Paolo Pantaleo, Saro Roberto Paparoni, Guido Parodi, Anna Sonia Petronio, Luigi Piatti, Emanuela Piccaluga, Carlo Pierli, Andrea Perkan, Antonino Piti, Arnaldo Poli, Angelo Bruno Ramondo, Maurizio Alessandro Reale, Bernhard Reimers, Flavio Luciano Ribichini, Roberta Rosso, Salvatore Sacca, Cosimo Sacra, Andrea Santarelli, Gennaro Sardella, Gaetano Satullo, Filippo Scalise, Massimo Siviglia, Leonardo Spedicato, Amerigo Stabile, Corrado Tamburino, Tullio Nicola Maria Tesorio, Salvatore Tolaro, Fabrizio Tomai, Carlo Trani, Renato Valenti, Orazio Valsecchi, Giuseppe Valva, Ferdinando Varbella, Carlo Vigna, Luigi Vignali, Sergio Berti
GIORNALE ITALIANO DI CARDIOLOGIA
(2018)