G-Protein Coupled Receptors (GPCRs): Signaling Pathways, Characterization, and Functions in Insect Physiology and Toxicology

Multiple cytochrome P450 genes: conferring high levels of permethrin resistance in mosquitoes, Culex quinquefasciatus

(2021) Ting Yang et al.   Scientific Reports

Significance of DopEcR, a G-protein coupled dopamine/ecdysteroid receptor, in physiological and behavioral response to stressors

(2020) Emily Petruccelli et al.   JOURNAL OF NEUROGENETICS

Impact of GPCR Structures on Drug Discovery

(2020) Miles Congreve et al.   CELL

Characterization of an adulticidal and larvicidal interfering RNA pesticide that targets a conserved sequence in mosquito G protein-coupled dopamine 1 receptor genes

(2020) Limb K. Hapairai et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Short neuropeptide F signaling regulates functioning of male reproductive system in Tenebrio molitor beetle

(2020) Paweł Marciniak et al.   Journal of Comparative Physiology B-Biochemical Systems and Environmental Physiology

MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host

(2020) Zhaojiang Guo et al.   Nature Communications

AmOctα2R: Functional Characterization of a Honeybee Octopamine Receptor Inhibiting Adenylyl Cyclase Activity

(2020) Wolfgang Blenau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological Characterization of the Stick Insect Carausius morosus Allatostatin-C Receptor with Its Endogenous Agonist

(2020) Ali Işbilir et al.   ACS Omega

New Routes in GPCR/β-Arrestin-Driven Signaling in Cancer Progression and Metastasis

(2019) Anna Bagnato et al.   Frontiers in Pharmacology

Physiological functions of a methuselah-like G protein coupled receptor in Lymantria dispar Linnaeus

(2019) Chuanwang Cao et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

The role of G protein‐coupled receptor‐related genes in cytochrome P450‐mediated resistance of the house fly Musca domestica (Diptera:Muscidae) to imidacloprid

(2019) Z. Ma et al.   INSECT MOLECULAR BIOLOGY

Role of the G-Protein-Coupled Receptor Signaling Pathway in Insecticide Resistance

(2019) Ting Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The steroid hormone 20-hydroxyecdysone binds to dopamine receptor to repress lepidopteran insect feeding and promote pupation

(2019) Xin-Le Kang et al.   PLoS Genetics

The steroid hormone 20-hydroxyecdysone induces phosphorylation and aggregation of stromal interacting molecule 1 for store-operated calcium entry

(2019) Cai-Hua Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-Induced Conformational Dynamics of A Tyramine Receptor from Sitophilus oryzae

(2019) Mac Kevin E. Braza et al.   Scientific Reports

Distribution of insecticide resistance and mechanisms involved in the arbovirus vector Aedes aegypti in Laos and implication for vector control

(2019) Sébastien Marcombe et al.   PLoS Neglected Tropical Diseases

Identification and cloning of the kinin receptor in the Chagas disease vector, Rhodnius prolixus

(2019) Vishal Sangha et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Functional characterization and quantitative expression analysis of two GnRH-related peptide receptors in the mosquito, Aedes aegypti

(2018) Alireza Oryan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The evolutionary origins of pesticide resistance

(2018) Nichola J. Hawkins et al.   BIOLOGICAL REVIEWS

Structural basis for the interaction of diapause hormone with its receptor in the silkworm, Bombyx mori

(2018) Zhangfei Shen et al.   FASEB JOURNAL

Elevenin regulates the body color through a G protein-coupled receptor NlA42 in the brown planthopper Nilaparvata lugens

(2018) Hironobu Uchiyama et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Juvenile hormone signaling - a mini review

(2018) Kang Li et al.   Insect Science

Analysis of Peptide Ligand Specificity of Different Insect Adipokinetic Hormone Receptors

(2018) Elisabeth Marchal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Function of G-Protein-Coupled Receptor-Regulatory Cascade in Southern House Mosquitoes (Diptera: Culicidae)

(2018) Ting Li et al.   JOURNAL OF MEDICAL ENTOMOLOGY

Prediction of the post-translational modifications of adipokinetic hormone receptors from solitary to eusocial bees

(2018) Huipeng Yang et al.   SOCIOBIOLOGY

G protein-coupled receptors in arthropod vectors: omics and pharmacological approaches to elucidate ligand-receptor interactions and novel organismal functions

(2018) Patricia V Pietrantonio et al.   Current Opinion in Insect Science

Evaluation of Aib and PEG-polymer insect kinin analogs on mosquito and tick GPCRs identifies potent new pest management tools with potentially enhanced biostability and bioavailability

(2018) Caixing Xiong et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Functional Characterization of Carboxylesterases in Insecticide Resistant House Flies, Musca Domestica

(2018) Xuechun Feng et al.   Jove-Journal of Visualized Experiments

GPCR annotation, G proteins, and transcriptomics of fire ant (Solenopsis invicta) queen and worker brain: An improved view of signaling in an invasive superorganism

(2018) Travis L. Calkins et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Protein kinase C mediates juvenile hormone–dependent phosphorylation of Na+/K+-ATPase to induce ovarian follicular patency for yolk protein uptake

(2018) Yu-Pu Jing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of extracellular matrix degradation and metastatic spread by IQGAP1 through endothelin-1 receptor signalling in ovarian cancer

(2018) Lidia Chellini et al.   MATRIX BIOLOGY

Adipokinetic Hormone Receptor Mediates Lipid Mobilization to Regulate Starvation Resistance in the Brown Planthopper, Nilaparvata lugens

(2018) Kai Lu et al.   Frontiers in Physiology

Adipokinetic hormone receptor gene identification and its role in triacylglycerol mobilization and sexual behavior in the oriental fruit fly ( Bactrocera dorsalis )

(2017) Qiu-Li Hou et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide

(2017) Maria Giulia Di Giglio et al.   Scientific Reports

The function of two P450s, CYP9M10 and CYP6AA7, in the permethrin resistance of Culex quinquefasciatus

(2017) Youhui Gong et al.   Scientific Reports

A critical role for the Drosophila dopamine D1-like receptor Dop1R2 at the onset of metamorphosis

(2016) Kimberly Regna et al.   BMC DEVELOPMENTAL BIOLOGY

Gs/Gi Regulation of Bone Cell Differentiation: Review and Insights from Engineered Receptors

(2016) E. Hsiao et al.   HORMONE AND METABOLIC RESEARCH

Regulation, Signaling, and Physiological Functions of G-Proteins

(2016) Viktoriya Syrovatkina et al.   JOURNAL OF MOLECULAR BIOLOGY

The Unique Dopamine/Ecdysteroid Receptor Modulates Ethanol-Induced Sedation in Drosophila

(2016) E. Petruccelli et al.   JOURNAL OF NEUROSCIENCE

Identification and functional characterization of a pyrokinin neuropeptide receptor in the Lyme disease vector, Ixodes scapularis

(2016) Kinsi Gondalia et al.   PEPTIDES

Leucokinin mimetic elicits aversive behavior in mosquitoAedes aegypti(L.) and inhibits the sugar taste neuron

(2016) Hyeogsun Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death

(2016) Ping Lin et al.   PLoS Pathogens

Identification and Characterization of the Corazonin Receptor and Possible Physiological Roles of the Corazonin-Signaling Pathway in Rhodnius prolixus

(2016) Zina Hamoudi et al.   Frontiers in Neuroscience

Ade novotranscriptome of the Malpighian tubules in non-blood-fed and blood-fed Asian tiger mosquitoesAedes albopictus: insights into diuresis, detoxification, and blood meal processing

(2016) Carlos J. Esquivel et al.   PeerJ

Identification of G protein-coupled receptors required for vitellogenin uptake into the oocytes of the red flour beetle, Tribolium castaneum

(2016) Hua Bai et al.   Scientific Reports

Insecticide Resistance in Mosquitoes: Impact, Mechanisms, and Research Directions

(2015) Nannan Liu   Annual Review of Entomology

β-Arrestin1 interacts with G protein-coupled receptor to desensitize signaling of the steroid hormone 20-hydroxyecdysone in the lepidopteran insect Helicoverpa armigera

(2015) Xiao-Qian Zhang et al.   CELLULAR SIGNALLING

Pharmacological characterization of a tyramine receptor from the southern cattle tick, Rhipicephalus (Boophilus) microplus

(2015) Aaron D. Gross et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Outside-in signaling - a brief review of GPCR signaling with a focus on the Drosophila GPCR family

(2015) C. D. Hanlon et al.   JOURNAL OF CELL SCIENCE

Cytochrome P450s – Their expression, regulation, and role in insecticide resistance

(2015) Nannan Liu et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Lucilia cuprina genome unlocks parasitic fly biology to underpin future interventions

(2015) Clare A. Anstead et al.   Nature Communications

Amino acid coevolution reveals three-dimensional structure and functional domains of insect odorant receptors

(2015) Thomas A. Hopf et al.   Nature Communications

G-protein-coupled receptor controls steroid hormone signaling in cell membrane

(2015) Di Wang et al.   Scientific Reports

A G-protein-coupled receptor regulation pathway in cytochrome P450-mediated permethrin-resistance in mosquitoes, Culex quinquefasciatus

(2015) Ting Li et al.   Scientific Reports

SNP Analysis Infers that Recombination Is Involved in the Evolution of Amitraz Resistance in Rhipicephalus microplus

(2015) Samantha Baron et al.   PLoS One

Activation of Bombyx neuropeptide G protein-coupled receptor A4 via a Gαi-dependent signaling pathway by direct interaction with neuropeptide F from silkworm, Bombyx mori

(2014) Xiaoyan Deng et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Identification and Characterization of Receptors for Ion Transport Peptide (ITP) and ITP-like (ITPL) in the SilkwormBombyx mori

(2014) Chiaki Nagai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gαq, Gγ1 and Plc21C Control Drosophila Body Fat Storage

(2014) Jens Baumbach et al.   Journal of Genetics and Genomics

Pigment Dispersing Factor Regulates Ecdysone Biosynthesis via Bombyx Neuropeptide G Protein Coupled Receptor-B2 in the Prothoracic Glands of Bombyx mori

(2014) Masatoshi Iga et al.   PLoS One

Role of G-protein-coupled Receptor-related Genes in Insecticide Resistance of the Mosquito, Culex quinquefasciatus

(2014) Ting Li et al.   Scientific Reports

Genome wide gene-expression analysis of facultative reproductive diapause in the two-spotted spider mite Tetranychus urticae

(2013) Astrid Bryon et al.   BMC GENOMICS

A whole transcriptomal linkage analysis of gene co-regulation in insecticide resistant house flies, Musca domestica

(2013) Ming Li et al.   BMC GENOMICS

Signaling by Drosophila capa neuropeptides

(2013) Shireen-A. Davies et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Activation of cAMP-response element-binding protein is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC in insect

(2013) Huipeng Yang et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Calcitonin receptor 1 (AedaeGPCRCAL1) hindgut expression and direct role in myotropic action in females of the mosquito Aedes aegypti (L.)

(2013) Hyeogsun Kwon et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Quantitative properties and receptor reserve of the DAG and PKC branch of Gq-coupled receptor signaling

(2013) Björn H. Falkenburger et al.   JOURNAL OF GENERAL PHYSIOLOGY

A comparison of the signalling properties of two tyramine receptors from Drosophila

(2013) Asha Bayliss et al.   JOURNAL OF NEUROCHEMISTRY

Identification and expression of PBAN/diapause hormone and GPCRs from Aedes aegypti

(2013) Man-Yeon Choi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Molecular cloning and functional characterization of the diapause hormone receptor in the corn earworm Helicoverpa zea

(2013) Hongbo Jiang et al.   PEPTIDES

Re-invigorating the insecticide discovery pipeline for vector control: GPCRs as targets for the identification of next gen insecticides

(2013) Catherine A. Hill et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Functional Characterization of the Short Neuropeptide F Receptor in the Desert Locust, Schistocerca gregaria

(2013) Senne Dillen et al.   PLoS One

Gαo Is Required for L-Canavanine Detection in Drosophila

(2013) Isabelle Devambez et al.   PLoS One

Identification and Expression of the CCAP Receptor in the Chagas’ Disease Vector, Rhodnius prolixus, and Its Involvement in Cardiac Control

(2013) Dohee Lee et al.   PLoS One

Involvement of the G-Protein-Coupled Dopamine/Ecdysteroid Receptor DopEcR in the Behavioral Response to Sex Pheromone in an Insect

(2013) Antoine Abrieux et al.   PLoS One

Natalisin, a tachykinin-like signaling system, regulates sexual activity and fecundity in insects

(2013) H. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcitonin-like diuretic hormones in insects

(2012) Meet Zandawala   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Rediocide A, an Insecticide, Induces G-Protein-Coupled Receptor Desensitization via Activation of Conventional Protein Kinase C

(2012) Lixin Cui et al.   JOURNAL OF NATURAL PRODUCTS

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function

(2012) Raymond C. Stevens et al.   NATURE REVIEWS DRUG DISCOVERY

Functional characterization of an arrestin gene on insecticide resistance of Culex pipiens pallens

(2012) Yan Sun et al.   Parasites & Vectors

Mechanism and Function of Drosophila capa GPCR: A Desiccation Stress-Responsive Receptor with Functional Homology to Human NeuromedinU Receptor

(2012) Selim Terhzaz et al.   PLoS One

Role in Diuresis of a Calcitonin Receptor (GPRCAL1) Expressed in a Distal-Proximal Gradient in Renal Organs of the Mosquito Aedes aegypti (L.)

(2012) Hyeogsun Kwon et al.   PLoS One

The Cyclic AMP Pathway

(2012) P. Sassone-Corsi   Cold Spring Harbor Perspectives in Biology

More than two decades of research on insect neuropeptide GPCRs: an overview

(2012) Jelle Caers et al.   Frontiers in Endocrinology

G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response

(2011) Jonitha Gardner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Large-scale RNAi screen of G protein-coupled receptors involved in larval growth, molting and metamorphosis in the red flour beetle

(2011) Hua Bai et al.   BMC GENOMICS

MosquitoAedes aegypti(L.) leucokinin receptor is critical forin vivofluid excretion post blood feeding

(2011) Cymon N. Kersch et al.   FEBS LETTERS

Isolation and functional characterization of an allatotropin receptor from Manduca sexta

(2011) Frank M. Horodyski et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Characterization of an allatotropin-like peptide receptor in the red flour beetle, Tribolium castaneum

(2011) Kristel Vuerinckx et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

TOR kinase complexes and cell migration

(2011) Lunhua Liu et al.   JOURNAL OF CELL BIOLOGY

Identification of the elusive peptidergic diuretic hormone in the blood-feeding bug Rhodnius prolixus: a CRF-related peptide

(2011) V. Te Brugge et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Functions of duplicated genes encoding CCAP receptors in the red flour beetle, Tribolium castaneum

(2011) Bin Li et al.   JOURNAL OF INSECT PHYSIOLOGY

GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis

(2011) Florence Verrier et al.   Nature Chemical Biology

Functional characterization of an allatotropin receptor expressed in the corpora allata of mosquitoes

(2011) Marcela Nouzova et al.   PEPTIDES

Genome Analysis of Cytochrome P450s and Their Expression Profiles in Insecticide Resistant Mosquitoes, Culex quinquefasciatus

(2011) Ting Yang et al.   PLoS One

Characterization of the 5-HT1A receptor of the honeybee (Apis mellifera) and involvement of serotonin in phototactic behavior

(2010) Markus Thamm et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Myoinhibiting peptides are the ancestral ligands of the promiscuous Drosophila sex peptide receptor

(2010) Jeroen Poels et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Synergistic Activation of Phospholipase C-β3 by Gαq and Gβγ Describes a Simple Two-State Coincidence Detector

(2010) Finly Philip et al.   CURRENT BIOLOGY

Functional characterization of bursicon receptor and genome-wide analysis for identification of genes affected by bursicon receptor RNAi

(2010) Hua Bai et al.   DEVELOPMENTAL BIOLOGY

Site-directed mutagenesis and PBAN activation of theHelicoverpa zeaPBAN-receptor

(2010) Man-Yeon Choi et al.   FEBS LETTERS

Bombyx prothoracicostatic peptides activate the sex peptide receptor to regulate ecdysteroid biosynthesis

(2010) N. Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics

(2010) P. Arensburger et al.   SCIENCE

G protein-coupled receptors stimulation and the control of cell migration

(2009) Mathieu Cotton et al.   CELLULAR SIGNALLING

Olfactory receptors: G protein-coupled receptors and beyond

(2009) Marc Spehr et al.   JOURNAL OF NEUROCHEMISTRY

The Year In G Protein-Coupled Receptor Research

(2009) Robert P. Millar et al.   MOLECULAR ENDOCRINOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Neuropeptide Receptor Transcriptome Reveals Unidentified Neuroendocrine Pathways

(2008) Naoki Yamanaka et al.   PLoS One

G12/G13-mediated signalling in mammalian physiology and disease

(2008) Thomas Worzfeld et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A genome-wide inventory of neurohormone GPCRs in the red flour beetle Tribolium castaneum

(2007) Frank Hauser et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY