Journal
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 41, Issue 10, Pages 815-822Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ibmb.2011.06.003
Keywords
G protein-coupled receptor; Orexin; Juvenile hormone; Male reproductive system; Insect neuropeptide
Categories
Funding
- Interuniversity Attraction Poles programs (Belgian Science Policy) [P6/14]
- Research Foundation of Flanders (FWO-Flanders) [G.0405.09]
- KU. Leuven Research Foundation [GOA/11/02]
- FLOF
- BOF of the K.U. Leuven
- FWO
Ask authors/readers for more resources
Following a reverse pharmacology approach, we identified an allatotropin-like peptide receptor in Tribolium castaneum. Allatotropins are multifunctional neuropeptides initially isolated from the tabacco hornworm, Manduca sexta. They have been shown to be myoactive, to be cardio-acceleratory, to inhibit active ion transport, to stimulate juvenile hormone production and release and to be involved in the photic entrainment of the circadian clock. A tissue distribution analysis of the T castaneum allatotropin-like peptide receptor by means of qRT-PCR revealed a prominent sexual dimorphism, the transcript levels being significantly higher in the male fat body and reproductive system. The endogenous ligand of the receptor, Trica-ATL, is able to increase the frequency and tonus of contractions in the gut and in the reproductive tract of mature red flour beetles. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available