Cross-Talk among Polymorphonuclear Neutrophils, Immune, and Non-Immune Cells via Released Cytokines, Granule Proteins, Microvesicles, and Neutrophil Extracellular Trap Formation: A Novel Concept of Biology and Pathobiology for Neutrophils

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Nuclear envelope rupture and NET formation is driven by PKCα‐mediated lamin B disassembly

(2020) Yubin Li et al.   EMBO REPORTS

Vaginal neutrophils eliminate sperm by trogocytosis

(2020) I Olivera-Valle et al.   HUMAN REPRODUCTION

Polymorphonuclear Cell Chemotaxis and Suicidal NETosis: Simultaneous Observation Using fMLP, PMA, H7, and Live Cell Imaging

(2020) Delou Pai et al.   Journal of Immunology Research

Circulating exosomal MicroRNAs: New non-invasive biomarkers of non-communicable disease

(2020) Jorge Armando Jiménez-Avalos et al.   MOLECULAR BIOLOGY REPORTS

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

(2019) Sebastian Boeltz et al.   CELL DEATH AND DIFFERENTIATION

Neutrophil extracellular traps exert both pro- and anti-inflammatory actions in rheumatoid arthritis that are modulated by C1q and LL-37

(2019) Matthieu Ribon et al.   JOURNAL OF AUTOIMMUNITY

The role of exosome in autoimmune connective tissue disease

(2019) Tian Zhu et al.   ANNALS OF MEDICINE

Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus

(2019) Saifur Rahman et al.   ANNALS OF THE RHEUMATIC DISEASES

Genomic Identification of Low-Density Granulocytes and Analysis of Their Role in the Pathogenesis of Systemic Lupus Erythematosus

(2019) Brian J. Kegerreis et al.   JOURNAL OF IMMUNOLOGY

The Neutrophil’s Role During Health and Disease

(2019) Pei Xiong Liew et al.   PHYSIOLOGICAL REVIEWS

Neutrophil Extracellular Traps Induce Intestinal Damage and Thrombotic Tendency in Inflammatory Bowel Disease

(2019) Tao Li et al.   Journal of Crohns & Colitis

Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression

(2019) Antonino Bruno et al.   Frontiers in Immunology

Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223

(2019) Carolina Jimenez Calvente et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology

(2019) Mithunan Ravindran et al.   Biomolecules

Neutrophil proteases degrade autoepitopes of NET‐associated proteins

(2019) C. M. Bont et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

First trimester neutrophil to lymphocyte ratio (NLR) and pregnancy outcome

(2019) Viktoria Christoforaki et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Neutrophil extracellular traps are a source of extracellular HMGB1 in lupus nephritis: associations with clinical and histopathological features

(2019) L P Whittall-García et al.   LUPUS

Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

(2019) Pragnesh Mistry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IgA-Mediated Killing of Tumor Cells by Neutrophils Is Enhanced by CD47–SIRPα Checkpoint Inhibition

(2019) Louise W. Treffers et al.   Cancer Immunology Research

Misunderstandings Between Platelets and Neutrophils Build in Chronic Inflammation

(2019) Giuseppe A. Ramirez et al.   Frontiers in Immunology

G-MDSC-derived exosomes attenuate collagen-induced arthritis by impairing Th1 and Th17 cell responses

(2019) Dongwei Zhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neutrophil extracellular traps identify patients at risk of increased disease activity and cardiovascular comorbidity in systemic lupus erythematosus

(2019) Stanley Moore et al.   JOURNAL OF RHEUMATOLOGY

The enigmatic neutrophil: what we do not know

(2018) Paul Kubes   CELL AND TISSUE RESEARCH

Exosomes and Ectosomes in Intercellular Communication

(2018) Jacopo Meldolesi   CURRENT BIOLOGY

Neutrophil extracellular traps in vasculitis, friend or foe?

(2018) Daniel Söderberg et al.   CURRENT OPINION IN RHEUMATOLOGY

Human T H 17 cell development requires processing of dendritic cell–derived CXCL8 by neutrophil elastase

(2018) Yuri Souwer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Netting Neutrophils Activate Autoreactive B Cells in Lupus

(2018) Nicolas Gestermann et al.   JOURNAL OF IMMUNOLOGY

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

(2018) Hanke L. Matlung et al.   Cell Reports

Neutrophils kill the parasite Trichomonas vaginalis using trogocytosis

(2018) Frances Mercer et al.   PLOS BIOLOGY

Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

(2018) Margot Zöller et al.   Frontiers in Immunology

Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis

(2018) Norma Maugeri et al.   Science Translational Medicine

Chromatin swelling drives neutrophil extracellular trap release

(2018) Elsa Neubert et al.   Nature Communications

Physiological Stimuli Induce PAD4-Dependent, ROS-Independent NETosis, With Early and Late Events Controlled by Discrete Signaling Pathways

(2018) Olga Tatsiy et al.   Frontiers in Immunology

Exosomes in inflammation and role as biomarkers

(2018) Lara Console et al.   CLINICA CHIMICA ACTA

Splenic Ly6G high mature and Ly6G int immature neutrophils contribute to eradication of S. pneumoniae

(2017) Justin F. Deniset et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Microparticles Deliver Active Myeloperoxidase to Injured Mucosa To Inhibit Epithelial Wound Healing

(2017) Thomas W. Slater et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps and Endothelial Dysfunction in Atherosclerosis and Thrombosis

(2017) Haozhe Qi et al.   Frontiers in Immunology

NETosis before and after Hyperglycemic Control in Type 2 Diabetes Mellitus Patients

(2017) Agostina Carestia et al.   PLoS One

Transcriptional firing helps to drive NETosis

(2017) Meraj A. Khan et al.   Scientific Reports

JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis

(2017) Meraj A. Khan et al.   Scientific Reports

Anti-TNFα agents curb platelet activation in patients with rheumatoid arthritis

(2016) Angelo A Manfredi et al.   ANNALS OF THE RHEUMATIC DISEASES

NETosis markers: Quest for specific, objective, and quantitative markers

(2016) Sakiko Masuda et al.   CLINICA CHIMICA ACTA

Alarmin human α defensin HNP1 activates plasmacytoid dendritic cells by triggering NF-κB and IRF1 signaling pathways

(2016) Fang Wang et al.   CYTOKINE

Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype

(2016) Michael Horckmans et al.   EUROPEAN HEART JOURNAL

Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation

(2016) Garyfalia Papadaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Deposition of microparticles by neutrophils onto inflamed epithelium: a new mechanism to disrupt epithelial intercellular adhesions and promote transepithelial migration

(2016) Veronika Butin-Israeli et al.   FASEB JOURNAL

Pathobiology of neutrophil-epithelial interactions

(2016) Jennifer C. Brazil et al.   IMMUNOLOGICAL REVIEWS

Human neutrophils in the saga of cellular heterogeneity: insights and open questions

(2016) Patrizia Scapini et al.   IMMUNOLOGICAL REVIEWS

Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing

(2016) R Sumagin et al.   Mucosal Immunology

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Membrane Transfer from Mononuclear Cells to Polymorphonuclear Neutrophils Transduces Cell Survival and Activation Signals in the Recipient Cells via Anti-Extrinsic Apoptotic and MAP Kinase Signaling Pathways

(2016) Ko-Jen Li et al.   PLoS One

Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy

(2016) Suchita Nadkarni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune and regulatory functions of neutrophils in inflammatory bone loss

(2016) George Hajishengallis et al.   SEMINARS IN IMMUNOLOGY

Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice

(2016) Yungang Wang et al.   Oncotarget

Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations

(2016) Fariborz Mobarrez et al.   Scientific Reports

Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome

(2015) Arun Cumpelik et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil extracellular trap formation is associated with autophagy-related signalling in ANCA-associated vasculitis

(2015) S. Tang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Neutrophil extracellular traps can activate alternative complement pathways

(2015) H. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Update on the Role of Neutrophils in Atherosclerotic Plaque Vulnerability

(2015) Federico Carbone et al.   CURRENT DRUG TARGETS

The B Cell–Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell–Dependent Bone Loss in Experimental Murine Periodontitis

(2015) Toshiharu Abe et al.   JOURNAL OF IMMUNOLOGY

Granulocytic Myeloid-Derived Suppressor Cells Accumulate in Human Placenta and Polarize toward a Th2 Phenotype

(2015) Natascha Köstlin et al.   JOURNAL OF IMMUNOLOGY

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Production of IL-8, VEGF and Elastase by Circulating and Intraplaque Neutrophils in Patients with Carotid Atherosclerosis

(2015) Franca Marino et al.   PLoS One

Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms

(2014) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis

(2014) D. N. Douda et al.   BLOOD

Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity

(2014) Felix C. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of a Novel Neutrophil Population: Proangiogenic Granulocytes in Second-Trimester Human Decidua

(2014) Hagai Amsalem et al.   JOURNAL OF IMMUNOLOGY

Neutrophil extracellular traps promote differentiation and function of fibroblasts

(2014) Akrivi Chrysanthopoulou et al.   JOURNAL OF PATHOLOGY

The Role of Hypoxia-Inducible Factor in Wound Healing

(2014) Wan Xing Hong et al.   Advances in Wound Care

Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function

(2013) D. Odobasic et al.   BLOOD

Myeloperoxidase (MPO)-specific CD4+ T cells contribute to MPO-anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis

(2013) Poh-Yi Gan et al.   CELLULAR IMMUNOLOGY

Macrophage Clearance of Neutrophil Extracellular Traps Is a Silent Process

(2013) C. Farrera et al.   JOURNAL OF IMMUNOLOGY

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue

(2012) G. Christoffersson et al.   BLOOD

Ectosomes of polymorphonuclear neutrophils activate multiple signaling pathways in macrophages

(2012) Ceylan Eken et al.   IMMUNOBIOLOGY

Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils

(2012) Ravi S. Keshari et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus

(2012) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bonding the foe – NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals

(2012) Christine Schorn et al.   Frontiers in Immunology

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Platelet–Leukocyte Interactions in Cardiovascular Disease and Beyond

(2010) Licia Totani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intercellular Trogocytosis Plays an Important Role in Modulation of Immune Responses

(2010) Khawaja Ashfaque Ahmed et al.   Cellular & Molecular Immunology

Ectosomes Released by Polymorphonuclear Neutrophils Induce a MerTK-dependent Anti-inflammatory Pathway in Macrophages

(2010) Ceylan Eken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A

(2010) Carmela De Santo et al.   NATURE IMMUNOLOGY

Leukocyte and platelet activation in patients with giant cell arteritis and polymyalgia rheumatica: A clue to thromboembolic risks?

(2009) Norma Maugeri et al.   AUTOIMMUNITY

Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption

(2009) A. Chakravarti et al.   BLOOD

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Polymorphonuclear neutrophils and T lymphocytes: strange bedfellows or brothers in arms?

(2009) Ingrid Müller et al.   TRENDS IN IMMUNOLOGY

Gene expression in systemic lupus erythematosus: Bone marrow analysis differentiates active from inactive disease and reveals apoptosis and granulopoiesis signatures

(2008) Magdalene Nakou et al.   ARTHRITIS AND RHEUMATISM

T lymphocytes in acute bacterial infection: increased prevalence of CD11b+cells in the peripheral blood and recruitment to the infected site

(2008) Christof Wagner et al.   IMMUNOLOGY

Filaments made from A- and B-type lamins differ in structure and organization

(2008) M. W. Goldberg et al.   JOURNAL OF CELL SCIENCE

Stabilization of HIF-1  is critical to improve wound healing in diabetic mice

(2008) I. R. Botusan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of Myeloperoxidase-Positive Neutrophils in Atherosclerotic Lesions in LDLR −/− Mice

(2007) Marcella van Leeuwen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY