Molecular Imaging of Apoptosis: The Case of Caspase-3 Radiotracers

Pre-targeted Imaging of Protease Activity Via In Situ Assembly of Nanoparticles

(2020) Jianghong Rao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mistiming Death: Modeling the Time-Domain Variability of Tumor Apoptosis and Implications for Molecular Imaging of Cell Death

(2020) Seth T. Gammon et al.   MOLECULAR IMAGING AND BIOLOGY

Development of [18F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis

(2020) Segundo Francisco García-Argüello et al.   Cancers

Detection of Active Caspase-3 in Mouse Models of Stroke and Alzheimer’s Disease with a Novel Dual Positron Emission Tomography/Fluorescent Tracer [68Ga]Ga-TC3-OGDOTA

(2019) Valeriy G. Ostapchenko et al.   Contrast Media & Molecular Imaging

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evaluation of apoptosis imaging biomarkers in a genetic model of cell death

(2019) Vessela Vassileva et al.   EJNMMI Research

Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7

(2019) Scott McComb et al.   Science Advances

Selective and Rapid Cell-Permeable Inhibitor of Human Caspase-3

(2019) Angelo Solania et al.   ACS Chemical Biology

Induction of Pyroptosis and Its Implications in Cancer Management

(2019) Yan-Yang Wang et al.   Frontiers in Oncology

Early Detection in a Mouse Model of Pancreatic Cancer by Imaging DNA Damage Response Signalling

(2019) James C Knight et al.   JOURNAL OF NUCLEAR MEDICINE

One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[123,125I]iodo-1,2,3-triazole derived Isatin SPECT Tracer

(2019) Matthias Glaser et al.   Scientific Reports

Cathepsins: Proteases that are vital for survival but can also be fatal

(2018) Seema Patel et al.   BIOMEDICINE & PHARMACOTHERAPY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Avenues to molecular imaging of dying cells: Focus on cancer

(2018) Anna A. Rybczynska et al.   MEDICINAL RESEARCH REVIEWS

Caspase-3 Substrates for Noninvasive Pharmacodynamic Imaging of Apoptosis by PET/CT

(2018) Brian J. Engel et al.   BIOCONJUGATE CHEMISTRY

Clinical translation of [18F]ICMT-11 for measuring chemotherapy-induced caspase 3/7 activation in breast and lung cancer

(2018) S. R. Dubash et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Apoptosis in ischemic heart disease

(2017) Elena Teringova et al.   Journal of Translational Medicine

Evaluation of [18F]CP18 as a Substrate-Based Apoptosis Imaging Agent for the Assessment of Early Treatment Response in Oncology

(2017) Sara Rapic et al.   MOLECULAR IMAGING AND BIOLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Structure and function of legumain in health and disease

(2016) Elfriede Dall et al.   BIOCHIMIE

The Dynamics of Apoptotic Cell Clearance

(2016) Michael R. Elliott et al.   DEVELOPMENTAL CELL

Early Prediction of Tumor Response to Treatment: Preclinical Validation of 99mTc-Duramycin

(2016) F. Elvas et al.   JOURNAL OF NUCLEAR MEDICINE

Radiation dosimetry of 18F-FDG PET/CT: incorporating exam-specific parameters in dose estimates

(2016) Brian Quinn et al.   BMC MEDICAL IMAGING

Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

(2015) Leslie O. Ofori et al.   ACS Chemical Biology

Novel fluorine-18 labeled 5-(1-pyrrolidinylsulfonyl)-7-azaisatin derivatives as potential PET tracers for in vivo imaging of activated caspases in apoptosis

(2015) Christopher M. Waldmann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Noninvasive Molecular Imaging of Apoptosis in a Mouse Model of Anthracycline-Induced Cardiotoxicity

(2015) H. Su et al.   Circulation-Cardiovascular Imaging

A Systematic Comparison of 18F-C-SNAT to Established Radiotracer Imaging Agents for the Detection of Tumor Response to Treatment

(2015) T. H. Witney et al.   CLINICAL CANCER RESEARCH

Isatin sulfonamides: potent caspases-3 and -7 inhibitors, and promising PET and SPECT radiotracers for apoptosis imaging

(2015) Panupun Limpachayaporn et al.   Future Medicinal Chemistry

Preclinical Kinetic Analysis of the Caspase-3/7 PET Tracer 18F-C-SNAT: Quantifying the Changes in Blood Flow and Tumor Retention After Chemotherapy

(2015) M. Palner et al.   JOURNAL OF NUCLEAR MEDICINE

Design, synthesis and initial characterisation of a radiolabelled [18F]pyrimidoindolone probe for detecting activated caspase-3/7

(2015) A. Udemba et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Peptide-Based Positron Emission Tomography Probe for In Vivo Detection of Caspase Activity in Apoptotic Cells

(2014) M. R. Hight et al.   CLINICAL CANCER RESEARCH

Imaging Caspase-3 Activation as a Marker of Apoptosis-Targeted Treatment Response in Cancer

(2014) Delphine L. Chen et al.   MOLECULAR IMAGING AND BIOLOGY

Caspase crosstalk: integration of apoptotic and innate immune signalling pathways

(2014) Emma M. Creagh   TRENDS IN IMMUNOLOGY

Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids

(2013) Chris J. Vickers et al.   ACS Chemical Biology

Positron Emission Tomography Imaging of Drug-Induced Tumor Apoptosis with a Caspase-Triggered Nanoaggregation Probe

(2013) Bin Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: Nonradioactive counterparts of putative PET-compatible apoptosis imaging agents

(2013) Panupun Limpachayaporn et al.   BIOORGANIC & MEDICINAL CHEMISTRY

18F-ICMT-11, a Caspase-3-Specific PET Tracer for Apoptosis: Biodistribution and Radiation Dosimetry

(2013) A. Challapalli et al.   JOURNAL OF NUCLEAR MEDICINE

Biodistribution and Radiation Dosimetry of 18F-CP-18, a Potential Apoptosis Imaging Agent, as Determined from PET/CT Scans in Healthy Volunteers

(2013) M. Doss et al.   JOURNAL OF NUCLEAR MEDICINE

Selective Detection and Inhibition of Active Caspase-3 in Cells with Optimized Peptides

(2013) Chris J. Vickers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evaluation of [18F]-CP18 as a PET Imaging Tracer for Apoptosis

(2013) Helen Su et al.   MOLECULAR IMAGING AND BIOLOGY

In Vitro and In Vivo Evaluation of the Caspase-3 Substrate-Based Radiotracer [18F]-CP18 for PET Imaging of Apoptosis in Tumors

(2013) Chun-Fang Xia et al.   MOLECULAR IMAGING AND BIOLOGY

Caspase Substrates and Inhibitors

(2013) M. Poreba et al.   Cold Spring Harbor Perspectives in Biology

Development of Small Molecular Probes for the Molecular Imaging of Apoptosis

(2012) Wenbin Zeng et al.   Anti-Cancer Agents in Medicinal Chemistry

Automated GMP Synthesis of [18F]ICMT-11 for In Vivo Imaging of Caspase-3 Activity

(2012) Robin Fortt et al.   NUCLEAR MEDICINE AND BIOLOGY

Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: Introduction of a hydrophilic group increases potency in a whole cell assay

(2011) Wenhua Chu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Radiotracers for Noninvasive Molecular Imaging of Tumor Cell Death

(2011) Janice Kapty et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes

(2011) Laura E Edgington et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Small-Molecule Biomarkers for Clinical PET Imaging of Apoptosis

(2010) A. Reshef et al.   JOURNAL OF NUCLEAR MEDICINE

Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography

(2009) Delphine L. Chen et al.   NUCLEAR MEDICINE AND BIOLOGY

Comparative Assessment of Substrates and Activity Based Probes as Tools for Non-Invasive Optical Imaging of Cysteine Protease Activity

(2009) Galia Blum et al.   PLoS One

Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide

(2009) Q.-D. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, Synthesis, and Biological Characterization of a Caspase 3/7 Selective Isatin Labeled with 2-[18F]fluoroethylazide

(2008) Graham Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY