Isatin sulfonamides: potent caspases-3 and -7 inhibitors, and promising PET and SPECT radiotracers for apoptosis imaging

Synthesis of 7-Halogenated Isatin Sulfonamides: Nonradioactive Counterparts of Caspase-3/-7 Inhibitor-Based Potential Radiopharmaceuticals for Molecular Imaging of Apoptosis

(2014) Panupun Limpachayaporn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preclinical Assessment of Carboplatin Treatment Efficacy in Lung Cancer by 18F-ICMT-11-Positron Emission Tomography

(2014) Timothy H. Witney et al.   PLoS One

Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: Nonradioactive counterparts of putative PET-compatible apoptosis imaging agents

(2013) Panupun Limpachayaporn et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7

(2013) Panupun Limpachayaporn et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, 18F-Radiolabeling, and in Vivo Biodistribution Studies of N-Fluorohydroxybutyl Isatin Sulfonamides using Positron Emission Tomography

(2013) Panupun Limpachayaporn et al.   JOURNAL OF MEDICINAL CHEMISTRY

18F-ICMT-11, a Caspase-3-Specific PET Tracer for Apoptosis: Biodistribution and Radiation Dosimetry

(2013) A. Challapalli et al.   JOURNAL OF NUCLEAR MEDICINE

Translational Imaging of Apoptosis

(2012) Graham Smith et al.   Anti-Cancer Agents in Medicinal Chemistry

Imaging apoptosis with positron emission tomography: ‘Bench to bedside’ development of the caspase-3/7 specific radiotracer [18F]ICMT-11

(2012) Quang-Dé Nguyen et al.   EUROPEAN JOURNAL OF CANCER

Automated GMP Synthesis of [18F]ICMT-11 for In Vivo Imaging of Caspase-3 Activity

(2012) Robin Fortt et al.   NUCLEAR MEDICINE AND BIOLOGY

A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis

(2012) Anwen M. Krause-Heuer et al.   MedChemComm

Metabolite Identification of a Radiotracer by Electrochemistry Coupled to Liquid Chromatography with Mass Spectrometric and Radioactivity Detection

(2011) Anne Baumann et al.   ANALYTICAL CHEMISTRY

Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: Introduction of a hydrophilic group increases potency in a whole cell assay

(2011) Wenhua Chu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Improved radiosynthesis of the apoptosis marker 18F-ICMT11 including biological evaluation

(2011) Matthias Glaser et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Isatin 1,2,3-triazoles as potent inhibitors against caspase-3

(2011) Yang Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody

(2011) Delphine L. Chen et al.   NUCLEAR MEDICINE AND BIOLOGY

3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3

(2009) Lisa M. Havran et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fluorinated isatin derivatives. Part 1: Synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors

(2009) Anil Kumar Podichetty et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fluorinated isatin derivatives. Part 3. New side-chain fluoro-functionalized pyrrolidinyl sulfonyl isatins as potent caspase-3 and -7 inhibitors

(2009) Anil Kumar Podichetty et al.   Future Medicinal Chemistry

Docking and 3D-QSAR Studies on Isatin Sulfonamide Analogues as Caspase-3 Inhibitors

(2009) Qi Wang et al.   Journal of Chemical Information and Modeling

Synthesis and in Vitro Evaluation of Sulfonamide Isatin Michael Acceptors as Small Molecule Inhibitors of Caspase-6

(2009) Wenhua Chu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorinated Isatin Derivatives. Part 2. NewN-Substituted 5-Pyrrolidinylsulfonyl Isatins as Potential Tools for Molecular Imaging of Caspases in Apoptosis

(2009) Anil K. Podichetty et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography

(2009) Delphine L. Chen et al.   NUCLEAR MEDICINE AND BIOLOGY

[18F]- and [11C]-Labeled N-benzyl-isatin sulfonamide analogues as PET tracers for Apoptosis: synthesis, radiolabeling mechanism, and in vivo imaging study of apoptosis in Fas-treated mice using [11C]WC-98

(2009) Dong Zhou et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide

(2009) Q.-D. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-activity correlation for a series of isatin derivatives, inhibitors of caspase 3

(2009) I. G. Tsygankova et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

Design, Synthesis, and Biological Characterization of a Caspase 3/7 Selective Isatin Labeled with 2-[18F]fluoroethylazide

(2008) Graham Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY