Article
Radiology, Nuclear Medicine & Medical Imaging
Jian Yang, Jia Deng, Dongmei Fan, Gefei Chen, Zhonglin Lu, Hanxiang Liu, Greta S. P. Mok, Yue Chen
Summary: This study demonstrates the potential of Ga-68-DOTA-IBA in the diagnosis of bone metastases, as it has high bone affinity and good safety. It also has the potential to be used in Lu-177 therapy.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tuula Tolvanen, Kari Kalliokoski, Simona Malaspina, Anna Kuisma, Salla Lahdenpohja, Ernst J. Postema, Matthew P. Miller, Mika Scheinin
Summary: The study investigated the safety, biodistribution, and internal radiation dosimetry of a novel F-18-labeled radiohybrid PSA imaging agent in healthy volunteers, showing favorable results for PET imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yali Long, Chang Yi, Renbo Wu, Yuying Zhang, Bing Zhang, Xinchong Shi, Xiangsong Zhang, Zhihao Zha
Summary: In this study, the distribution, tumor detecting ability, and radiation dosimetry of [F-18]DFA in humans were evaluated using PET imaging. [F-18]DFA showed high uptake and retention in tumors, and exhibited a similar distribution pattern as AA. This suggests that [F-18]DFA may be a promising radiopharmaceutical for identifying tumors with high affinity for SVCT2 and monitoring AA distribution in both normal tissues and tumors.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Chemistry, Medicinal
Xiaojun Zhang, Yitian Wu, Qi Zeng, Tianxin Xie, Shulin Yao, Jinming Zhang, Mengchao Cui
Summary: The study designed, synthesized, and evaluated three more lipophilic F-18-labeled PSMA tracers, investigating the effect of lipophilicity on their distribution and excretion in different species. Higher lipophilicity led to increased radioactivity accumulation in the liver of primates and humans, as well as reduced excretion to the bladder through urine. The screened tracer [F-18]8c showed low bladder retention and good imaging properties in patients with prostate cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Falko Ensle, Jan A. Schaab, Florentia Dimitriou, Martin W. Huellner, Alexander Maurer
Summary: We report the F-18-FDG PET/CT findings of an internal thoracic vein tumor thrombus in a 76-year-old woman with melanoma. The restaging F-18-FDG PET/CT revealed disease progression with an internal thoracic vein tumor thrombus associated with sternal bone metastasis. Although cutaneous malignant melanoma can metastasize to any organ, direct tumor invasion of veins leading to tumor thrombus formation is an extremely rare complication.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Biotechnology & Applied Microbiology
Jiaying Zhang, Zefang Lin, Xiaojun Zhang, Rong Lin, Mengchao Cui, Weibing Miao, Shaobo Yao
Summary: The injection of Ga-68-DOTA-DiPSMA is safe and associated with low absorbed and effective doses. Ga-68-DOTA-DiPSMA demonstrates favorable kinetics and imaging characteristics, showing potential as an alternative for gallium-68-labeled PSMA clinical PET.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Pardeep Kumar, Riptee Thakur, Pratap Chandra Acharya, Hosahalli K. Mohan, U. N. Pallavi, Divya Maheshwari, Afsal K. M. Mohammed, Aishwarya Kumar, Sridhar Goud Nerella, Raman Kumar Joshi, Manoj Kumar, Chandana Nagaraj
Summary: The study successfully synthesized a F-18 labeled tracer AVT-011 and demonstrated its specificity for Pgp and safety for patient use.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiao Yang, Wenjia Zhu, Chao Ren, Hongfeng Ji, Dongchun Wang, Yu Liu, Fang Li, Yanrong Du, Yuanhao Liu, Li Huo
Summary: D-[F-18]FBPA exhibited lower distribution and activity in normal brain, liver, spleen, pancreas, and skeleton compared to its L-isomer. The study confirmed the radiological safety of D-[F-18]FBPA, laying the foundation for further clinical trials in cancer patients.
NUCLEAR MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aline Delva, Michel Koole, Kim Serdons, Guy Bormans, Longbin Liu, Jonathan Bard, Vinod Khetarpal, Celia Dominguez, Ignacio Munoz-Sanjuan, Andrew Wood, Mette Skinbjerg, Yuchuan Wang, Wim Vandenberghe, Koen Van Laere
Summary: In this study, the biodistribution and dosimetry of two tracers designed for PET imaging of aggregated mutant huntingtin (mHTT) in the brain were investigated in healthy volunteers. The results suggest that both tracers are safe for in vivo PET imaging in humans. One tracer showed promising kinetic properties in the brain, while the other may accumulate a brain-penetrant metabolite.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Esmaeil Gharepapagh, Ashraf Fakhari, Tahereh Firuzyar, Ashkan Shomali, Farzaneh Azimi
Summary: A new Tc-99m N-doped graphene quantum dot Tc-99m-(N-GQD) moiety has been developed for possible radiolabeling of molecules with chelation limitations and poor water solubility. The Tc-99m-(N-GQDs) were synthesized and characterized with high purity, demonstrating high radiochemical purity after radiolabeling and effective elimination by kidneys in biodistribution studies. Dosimetry studies showed kidneys as critical organs for the effective radiation dose of Tc-99m-(N-GQDs).
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Computer Science, Artificial Intelligence
Jaewon Yang, Jae Ho Sohn, Spencer C. Behr, Grant T. Gullberg, Youngho Seo
Summary: This study demonstrates the feasibility of CT-less attenuation and scatter correction in whole-body PET using deep learning, highlighting the potential benefits and pitfalls. Results show that deep learning-corrected PET images exhibit high similarity with ASC-corrected PET, but also reveal potential issues such as radiation dose reduction and artifact removal, as well as possible false-negative and false-positive results.
RADIOLOGY-ARTIFICIAL INTELLIGENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Leonie Beyer, Astrid Gosewisch, Simon Lindner, Friederike Voelter, Lena M. Mittlmeier, Reinhold Tiling, Matthias Brendel, Clemens C. Cyran, Marcus Unterrainer, Johannes Ruebenthaler, Christoph J. Auernhammer, Christine Spitzweg, Guido Boening, F. J. Gildehaus, Klaus Jurkschat, Carmen Wangler, Bjoern Wangler, Ralf Schirrmacher, Vera Wenter, Andrei Todica, Peter Bartenstein, Harun Ilhan
Summary: This study demonstrated the high tumor-to-background ratios and comparable effective dose of [F-18]SiTATE-PET/CT in NET patients from 60 to 180 minutes after injection, with the best compromise between image quality and tumor-to-background contrast reached at 120 minutes followed by 60 minutes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Langbein, Alexander Wurzer, Andrei Gafita, Andrew Robertson, Hui Wang, Ayca Arcay, Michael Herz, Hans-Juergen Wester, Wolfgang A. Weber, Matthias Eiber
Summary: This study found that the time between synthesis and injection and the decrease in specific activity of F-18-rhPSMA-7.3 had only minor effects on its biodistribution in patients. This suggests that F-18-labeled PSMA ligands can be produced centrally and shipped to PET clinics similar to F-18-FDG.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Therriault, Andrea L. Benedet, Tharick A. Pascoal, Melissa Savard, Nicholas J. Ashton, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Gleb Bezgin, Tina Wang, Jaime Fernandes-Arias, Gassan Massarweh, Paolo Vitali, Henrik Zetterberg, Kaj Blennow, Paramita Saha-Chaudhuri, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto
Summary: This study assessed multiple methods for determining an optimal cutoff for F-18-AZD4694 PET positivity, with good convergence among different approaches. The findings suggest that a threshold of 1.55 SUVR may have reliable discriminative accuracy for amyloid-beta positivity on PET imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Claudia S. Roldan, Jie Jane Chen, M. Mohsin Fareed, M. Yahya Hameed, Thomas M. Churilla, Miriam N. Lango, Thomas J. Galloway
Article
Otorhinolaryngology
Barbara Ebersole, Miriam Lango, John Ridge, Elizabeth Handorf, Jeffrey Farma, Sarah Clark, Nausheen Jamal
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2020)
Article
Medicine, Research & Experimental
Jonathan A. Harounian, Nicole Molin, Thomas J. Galloway, Drew Ridge Facs, Jessica Bauman, Jeffrey Farma, Sanjay Reddy, Miriam N. Lango
Summary: This study found that Merkel cell carcinoma patients with lymphovascular invasion (LVI) and positive sentinel lymph node (SLN) had worse prognostic outcomes. Sentinel lymph node biopsy assists in risk stratification and radiation treatment planning in MCC.
Article
Otorhinolaryngology
Douglas Y. Lee, Jesty Abraham, Eric Ross, John A. Ridge, Miriam N. Lango, Jeffrey C. Liu, Jessica R. Bauman, Vladimir Avkshtol, Thomas J. Galloway
Summary: Rapid recurrence in head and neck cancer patients is underestimated, with 20% experiencing it prior to initiating postoperative radiation therapy. Extranodal extension was the only predictor of rapid recurrence, and rapid recurrence was the strongest predictor of poor overall survival outcomes.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Alexander W. MacFarlane, Ho-Man Yeung, R. Katherine Alpaugh, Essel Dulaimi, Paul F. Engstrom, Arvind Dasari, Kerry S. Campbell, Namrata Vijayvergia
Summary: This study investigated the use of pembrolizumab in previously treated patients with metastatic extra-pulmonary G3 NENs and found limited activity of the drug, but highlighted potential immune biomarkers associated with treatment outcomes. Patients with higher baseline peripheral T-cell count and reduced activation of T and NK cell subsets had better progression-free survival. However, increased post-treatment TIGIT expression and elevated baseline TIM-3 expression may limit the efficacy of pembrolizumab, suggesting a rationale for combining immunotherapy to treat extra-pulmonary G3 NENs.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Saad A. Khan, Michael Burke, Fang Zhu, Dong-Hua Yang, Cara Dubyk, Ranee Mehra, Miriam J. Lango, John A. Ridge, David J. Sher, Barbara Burtness
Summary: High expression of Survivin is associated with shorter overall survival in head and neck squamous cell carcinoma, including patients treated with chemotherapy or radiation. There is no correlation between p16 expression and Survivin levels.
Article
Otorhinolaryngology
Miriam Lango, Yelizaveta Shnayder
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
(2021)
Article
Oncology
Musaddiq J. Awan, Haley Gittleman, Jill Barnholtz-Sloan, Mitchell Machtay, Phuc Felix Nguyen-Tan, David I. Rosenthal, Christopher Schultz, Bradley J. Huth, Wade L. Thorstad, Steven J. Frank, Harold Kim, Robert L. Foote, Miriam N. Lango, George Shenouda, Mohan Suntharalingam, Jonathan Harris, Qiang Zhang, Quynh-Thu Le, Min Yao
Summary: This study developed and validated easy-to-use nomograms that can predict the outcomes of patients with LSCC. Nomograms were built using factors such as age, gender, T-stage, N-stage, and treatment cycles, and their effectiveness was confirmed through internal and external validation.
Article
Oncology
William H. Ward, Caitlin R. Meeker, Elizabeth Handorf, Maureen Hill, Margret Einarson, R. Katherine Alpaugh, Thomas L. Holden, Igor Astsaturov, Crystal S. Denlinger, Michael J. Hall, Sanjay S. Reddy, Elin R. Sigurdson, Efrat Dotan, Matthew Zibelman, Joshua E. Meyer, Jeffrey M. Farma, Namrata Vijayvergia
Summary: The study aimed to quantify physical activity in patients with colorectal cancer using a wearable tracker Fitbit Charge and investigate its relationship with patients' overall health status and treatment tolerance. The results showed a significant correlation between patients' overall PS levels and SPD step counts, indicating that SPD can serve as a supplement to PS assessment and help predict toxicities.
JCO CLINICAL CANCER INFORMATICS
(2021)
Meeting Abstract
Oncology
Rashida Ginwala, Alexander Macfarlane, David Liu, R. K. Alpaugh, Joanne Xiu, Zoran Gatalica, W. M. Korn, Eliezer M. Van Allen, Kerry S. Campbell, Alexander Kutikov, Elizabeth Plimack, Philip H. Abbosh
Article
Oncology
Sandra Fernandez, Alexander W. MacFarlane, Mowafaq Jillab, Maria F. Arisi, Jennifer Yearley, Lakshmanan Annamalai, Yulan Gong, Kathy Q. Cai, R. Katherine Alpaugh, Massimo Cristofanilli, Kerry S. Campbell
BREAST CANCER RESEARCH
(2020)
Meeting Abstract
Oncology
J. K. Wong, A. MacFarlane, K. Devarajan, R. M. Shulman, R. K. Alpaugh, N. Burbure, M. A. Hallman, D. M. Geynisman, E. M. Horwitz, K. Campbell, J. E. Meyer
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Meeting Abstract
Oncology
Daniel Adams, Steven H. Lin, Harvey Pass, Saranya Chumsri, Rena G. Lapidus, Martin Edelman, Raymond C. Bergan, Susan Tsai, Rebecca Aft, Sreeraj Pillai, Mark Watson, Amy K. Kim, Kazuaki Chikamatsu, Masanori Hayashi, David M. Loeb, Navin R. Pinto, R. Katherine Alpaugh, Cha-Mei Tang, Thai Huu Ho, Jeffrey R. Marks
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Meeting Abstract
Oncology
Phillip H. Abbosh, Uttam Satyal, David Liu, Ilsiya Ibragimova, Lauren Szeto, Benjamin Miron, James Ford, Daniel Parker, Aeen Asgar, Daniel M. Geynisman, R. Katherine Alpaugh, Paul Cairns, Costas D. Lallas, Edouard J. Trabulsi, Jean Hoffman-Censits, Eliezer M. Van Allen, Alexander Kutikov, Elizabeth R. Plimack
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Benjamin Miron, Jean H. Hoffman-Censits, Fern Anari, John O'Neill, Daniel M. Geynisman, Matthew R. Zibelman, Alexander Kutikov, Rosalia Viterbo, Richard E. Greenberg, David Chen, Costas D. Lallas, Edouard J. Trabulsi, R. Katherine Alpaugh, Essel Dulaimi, Erica A. Golemis, Robert Uzzo, Eric A. Ross, Elizabeth R. Plimack
EUROPEAN UROLOGY ONCOLOGY
(2020)