Article
Endocrinology & Metabolism
Christophe Mallet, Ludivine Boudieu, Sylvain Lamoine, Catherine Coudert, Yves Jacquot, Alain Eschalier
Summary: The peptide ER alpha 17p derived from human estrogen receptor alpha (ER alpha) shows anti-proliferative effects in breast cancer cells through GPER, and reduces xenografted human breast tumors in mice. It also demonstrates anti-hyperalgesic effects in a chronic mice model of inflammation, and reduces paw swelling in a carrageenan-induced inflammation model. This suggests that ER alpha 17p, as a GPER inverse agonist, could be a potential treatment for controlling hyperalgesia and inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takahisa Hirokawa, Taeko Horie, Yurie Fukiyama, Masashi Mimura, Shinji Takai, Teruyo Kida, Hidehiro Oku
Summary: The study identified that the overactivation of Cdk5 is associated with the development of tauopathies. Roscovitine, a Cdk5 inhibitor, reduces the phosphorylation level of tau protein and mitigates the pathologic phosphorylation of tau by inhibiting the calpain signaling pathway, thereby alleviating the degeneration of RGCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anesthesiology
Sam Singleton, Claire Sneddon, Alice Bakina, Jeremy J. Lambert, Tim G. Hales
Summary: Fragmented maternal care in mice affects pain sensitivity, morphine response, and inflammatory hypersensitivity, resulting in decreased basal sensitivity and enhanced vulnerability to persistent inflammatory hypersensitivity.
Article
Neurosciences
Nathan M. Sharfman, Leslie K. Kelley, Maria E. Secci, Nicholas W. Gilpin
Summary: Chronic inflammatory pain is a significant subset of chronic pain diagnoses, affecting a large number of individuals and incurring substantial economic costs. Studies suggest that melanocortin 4 receptors (MC4Rs) may play a role in pain signaling and pain-like behaviors, particularly in the central amygdala (CeA). However, the exact role of MC4Rs in chronic inflammatory pain in males and females is not fully understood.
Article
Integrative & Complementary Medicine
Barbara B. Garrido-Suarez, Gabino Garrido, Addis Bellma Menendez, Nelson Merino, Odalys Valdes, Nilia de la Paz, Aylema Romero, Livan Delgado, Miguel D. Fernandez, Octavio Pineros, Rene Delgado-Hernandez
Summary: The present study evaluated the antinociceptive activity of Calendula officinalis L. cream on inflammatory hypernociception. The results showed that 10% or 30% concentration of Calendula cream could reduce licking/biting behavior and edema in rats, and it worked through antioxidant stress and peripheral opioid mechanisms. These findings may have an impact on the clinical management of painful inflammatory diseases.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Pharmacology & Pharmacy
Rodrigo Maia-Marques, Igor M. R. Nascimento, Pedro S. S. Lauria, Ellen C. P. da Silva, Darizy F. Silva, Luciana L. Casais-e-Silva
Summary: Venom from Bothrops leucurus induces severe pain and mechanical hyperalgesia, involving neurotransmitters, nitric oxide, and prostaglandins. Inhibiting specific inflammatory mediators pathways may be an effective therapeutic strategy for pain management during envenoming.
Article
Neurosciences
Silviane F. de Magalhaes, Luis P. Manzo, Felipe M. de Faria, Maria C. de Oliveira-Fusaro, Catarine M. Nishijima, Willians F. Vieira, Ivan J. M. Bonet, Gilson G. dos Santos, Claudia H. Tambeli, Carlos A. Parada
Summary: TNF-alpha plays a key role in the development of inflammatory hyperalgesia by stimulating the release of pro-inflammatory cytokines and increasing nociceptors' susceptibility to the action of final inflammatory mediators. This mechanism may also explain the analgesic action of thalidomide.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Oncology
Xichun Zhu, Lihui Yue, Chunyan Fan, Yuting Liu, Yong Wang, Hongwei Zhao
Summary: The study revealed that the Cdk5-Syn-SNARE pathway plays a crucial role in acute and chronic inflammatory pain, and blocking the activation of this pathway is beneficial in exerting analgesic effects.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Patricia Garcia-Fernandez, Colette Reinhold, Nurcan Ueceyler, Claudia Sommer
Summary: Polyneuropathy (PNP) refers to diseases of the peripheral nervous system, with 50% of cases presenting with neuropathic pain. Certain types of PNP show pain restricted to the distal leg skin, indicating a local regulatory process leading to pain. This study suggests that a pro-inflammatory pathway mediated by NF-κB may contribute to pain development in patients with painful PNP. Our findings support the hypothesis of local inflammatory processes involved in pain in PNP, and suggest disrupted anti-inflammatory pathways in inflammatory PNP involving TRPV1 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yang Yang, Wei Zhou, Xiuqi Xu, Xianxiu Ge, Fei Wang, Guang-Qin Zhang, Lin Miao, Xueting Deng
Summary: This study suggests that Aprepitant alleviates inflammatory pain in mice by inhibiting the phosphorylation of JNK and p38, as well as the NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Anesthesiology
Ryu Komatsu, Michael Nash, Shane Mandalia, Emily Dinges, Umar Kamal, Davin Singh, Hani El-Omrani, Anjum Anwar, Carlos Delgado, Taylor M. Ziga, Brendan Carvalho
Summary: This study aimed to predict opioid consumption and pain intensity after cesarean delivery. The results showed that previous opioid consumption and pain scores had weak predictive ability for opioid consumption and pain after the index cesarean delivery.
ANESTHESIA AND ANALGESIA
(2022)
Article
Chemistry, Medicinal
Zulkifal Malik, Muzaffar Abbas, Lina Tariq Al Kury, Fawad Ali Shah, Mahboob Alam, Arif-ullah Khan, Humaira Nadeem, Saad Alghamdi, Muhammad Umar Khayam Sahibzada, Shupeng Li
Summary: The study investigated the effects of thiazolidine derivatives 1b and 1d on inflammatory pain in mice. The compounds attenuated carrageenan-induced thermal hyperalgesia and mechanical allodynia, reduced IL-1 beta expression in the spinal cord, and were found to be safe with no motor coordination deficits.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Neurosciences
Michiel van der Vlist, Ramin Raoof, Hanneke L. D. M. Willemen, Judith Prado, Sabine Versteeg, Christian Martin Gil, Martijn Vos, Roeland E. Lokhorst, R. Jeroen Pasterkamp, Toshiyuki Kojima, Hajime Karasuyama, William Khoury-Hanold, Linde Meyaard, Niels Eijkelkamp
Summary: The resolution of inflammatory pain is actively controlled by macrophages through the transfer of mitochondria to sensory neurons. This process requires the expression of CD200R on macrophages and the non-canonical CD200R ligand iSec1 on sensory neurons.
Article
Anesthesiology
Markus Dieterle, Laura Zurbriggen, Eckhard Mauermann, Katja Mercer-Chalmers-Bender, Priska Frei, Wilhelm Ruppen, Tobias Schneider
Summary: This study suggests that a high single-oral dose of 1600 mg cannabidiol is not effective in reducing opioid-induced hyperalgesia (OIH).
Article
Neurosciences
Luiz F. Ferrari, JunZhu Pei, Michael Zickella, Charles Rey, Jacqueline Zickella, Anna Ramirez, Norman E. Taylor
Summary: The research indicates that dopamine neurons in the PAG modulate analgesia by regulating the RVM. The analgesic effects of D-amphetamine and its PAG D2 receptor-mediated action were found to be controlled through the RVM pathway.
Article
Medicine, General & Internal
Jinmiao Lu, Qin Li, Lin Zhu, Chao Chen, Zhiping Li
Article
Clinical Neurology
Yuwen Tang, Zhiyou Peng, Shoujun Tao, Jianliang Sun, Wenyuan Wang, Xuejiao Guo, Gonglu Liu, Xianzhe Luo, Yuan Chen, Yue Shen, Haixiang Ma, Peng Xu, Qinghua Li, Honghai Zhang, Zhiying Feng
PAIN RESEARCH & MANAGEMENT
(2020)
Article
Neurosciences
Yan Wang, Guangfei Wang, Jie Tao, Xiaoxia Li, Lan Hu, Qin Li, Jinmiao Lu, Youbin Li, Zhiping Li
Article
Pharmacology & Pharmacy
Guangfei Wang, Qiaofeng Ye, Yidie Huang, Jinmiao Lu, Hong Xu, Zhiping Li
Summary: This study developed a population pharmacokinetic model of MPA in children with Juvenile dermatomyositis and optimized the limited sampling strategy. Results showed that the AUC(0-12 h) calculated from the three-point sampling strategy by removing the 20 minutes post-dose time point had the strongest correlation with the AUC(0-12 h) from the four-point sampling strategy.
Article
Medicine, Research & Experimental
Yue Shen, Hai Xiang Ma, Han Lu, Hai Ting Zhao, Jian Liang Sun, Yuan Cheng, Hong Hai Zhang
Summary: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of mortality in patients with intractable epilepsy, and its pathogenesis remains poorly understood. Previous findings suggest that atomoxetine may suppress seizure-induced respiratory arrest (S-IRA) through NE/NE alpha-1R interactions, highlighting NE alpha-1R as a potential therapeutic target for preventing SUDEP.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Youjia Fan, Rong Dong, Honghai Zhang, Buwei Yu, Han Lu
Summary: The current clinical treatment for neuropathic pain only targets the nervous system and its effectiveness is limited. However, studies have shown that neuropathic pain is the combined result of the sensory nervous system and the immune system. This study reviews the role of SIRT1 in neuropathic pain from a neuroimmune perspective.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Biotechnology & Applied Microbiology
Li Shen, Yiguo Jiang, Jinmiao Lu, Guangfei Wang, Xiaolan Zhang, Sumei He, Cheng Wang, Zhiping Li
Summary: The study explored the molecular mechanism of Jinchan Oral Liquid (JOL) in treating RSV pneumonia in children using network pharmacology, identifying active components, related targets, and pathways. The results suggested that JOL may act through the TNF and IL17 signaling pathways, with active compounds showing good affinity with core genes. The approach of network pharmacology may aid in discovering multitarget drugs for complex diseases.
BIOMED RESEARCH INTERNATIONAL
(2021)
Review
Medicine, Research & Experimental
LeYuan Gu, Qian Yu, Yue Shen, YuLing Wang, Qing Xu, HongHai Zhang
Summary: This article summarizes the latest advances in understanding the pathogenic mechanisms of Sudden Unexpected Death in Epilepsy (SUDEP), with a focus on the role of sleep-disordered breathing (SDB) and its related neural mechanisms. Targeting monoaminergic neurons is proposed as a promising approach to preventing SUDEP.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Jinmiao Lu, Xunjie Zhang, Hong Xu, Zhiping Li
Summary: The Bacillus Calmette-Guerin (BCG) vaccine is provided free of charge in China, and over 300 million newborns have been vaccinated. Rare adverse events have been reported, including pneumonia, lymphadenitis, and septicemia. The mortality rate is higher for preterm infants compared to full-term infants.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Mathematical & Computational Biology
Li Shen, Jinmiao Lu, Guangfei Wang, Cheng Wang, Zhiping Li
Summary: Using network pharmacology and molecular docking, this study explored the molecular targets and mechanism of the traditional Chinese medicine YuPingFeng (YPF) for the treatment of asthma. The results showed that YPF can alleviate asthma symptoms through multiple pathways and targets, and has good affinity with core genes related to asthma.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
HaiXiang Ma, Qian Yu, Yue Shen, XiTing Lian, LeYuan Gu, YuLing Wang, Qing Xu, Han Lu, HaiTing Zhao, Chang Zeng, Kazuki Nagayasu, HongHai Zhang
Summary: This study found that the 5-HT2AR in the pre-Botzinger complex plays an important role in SUDEP, and the serotonergic neural circuit between DR and PBC is involved in the generation of S-IRA.
Article
Multidisciplinary Sciences
XiTin Lian, Qin Xu, YuLin Wang, GuLeYuan Gu, Qian Yu, WeiHui Shao, HaiXiang Ma, Yue Shen, Lu Liu, JiaXuan Gu, HongHai Zhang
Summary: Seizure-induced respiratory arrest (S-IRA) has been recognized as a main cause of sudden unexpected death in epilepsy (SUDEP), but the involvement of other factors such as cardiac arrhythmias cannot be excluded. This study found that the locus coeruleus (LC) and peripheral noradrenergic neurotransmission play a role in S-IRA, and the protective effect of atomoxetine in reducing S-IRA and SUDEP can be reversed by esmolol hydrochloride. Moreover, the connectivity between the LC and heart was investigated, suggesting the regulation of SUDEP occurrence through b1-adrenergic receptors on cardiomyocytes by noradrenergic neurons in the LC.
Article
Biochemical Research Methods
YuLing Wang, Qing Xu, Qian Yu, LeYuan Gu, HaiXiang Ma, Yue Shen, XiTing Lian, WeiHui Shao, JiaXuan Gu, Lu Liu, HongHai Zhang
Summary: The study highlights the important role of the dorsal raphe nucleus (DR) and the pre-Botzinger complex (PBC) in regulating seizure-induced respiratory arrest (S-IRA), a leading cause of sudden unexpected death in epilepsy. The authors employ pharmacological, optogenetic, and retrograde labeling techniques to specifically modulate the serotonergic pathway between the DR and PBC and investigate the role of the 5-hydroxytryptophan (5-HT) neural circuit in S-IRA. Detailed instructions on the implantation of optical fibers, viral infusion, and optogenetic techniques are provided for further exploration. For a comprehensive understanding of the protocol, refer to Ma et al. (2022).
Article
Cell Biology
Yiwei Liao, Sha Huang, Yuhu Zhang, Honghai Zhang, Haiting Zhao
Summary: CCN1 is found to be involved in the process of epilepsy seizure, and its decrease can protect brain tissue from oxidative stress and neuronal apoptosis.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
HaiXiang Ma, LeYuan Gu, YuLing Wang, Qing Xu, Yuanli Zhang, WeiHui Shao, Qian Yu, XiTing Lian, Lu Liu, JiaXuan Gu, Na Ji, XiaoLing Liu, Kazuki Nagayasu, HongHai Zhang
Summary: Through pharmacological interventions and optogenetic techniques, the role of the 5-HT system in anesthetic awakening was explored. Exogenous administration of 5-HTP and optogenetic activation of 5-HT neurons in the DR were found to significantly shorten the emergence time of sevoflurane anesthesia in mice. Additionally, the 5-HT1A and 5-HT2A/C receptors located in the DR were identified as important regulators of general anesthetic awakening.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.