Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer's disease therapeutics

Current understanding of metal ions in the pathogenesis of Alzheimer’s disease

(2020) Lu Wang et al.   Translational Neurodegeneration

Scope of β-Secretase (BACE1)-Targeted Therapy in Alzheimer’s Disease: Emphasizing the Flavonoid Based Natural Scaffold for BACE1 Inhibition

(2020) Sucharita Das et al.   ACS Chemical Neuroscience

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Mutation profile of APP, PSEN1, and PSEN2 in Chinese familial Alzheimer's disease

(2019) Ying Gao et al.   NEUROBIOLOGY OF AGING

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Natural Compounds with Anti-BACE1 Activity as Promising Therapeutic Drugs for Treating Alzheimerʼs Disease

(2019) Mehjabeen Naushad et al.   PLANTA MEDICA

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

Multi-potent Natural Scaffolds Targeting Amyloid Cascade: In Search of Alzheimer's Disease Therapeutics

(2018) Sandipan Chakraborty   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Multi-functional neuroprotective activity of neohesperidin dihydrochalcone: a novel scaffold for Alzheimer's disease therapeutics identified via drug repurposing screening

(2018) Sandipan Chakraborty et al.   NEW JOURNAL OF CHEMISTRY

Calcium signaling in Alzheimer's disease & therapies

(2018) Benjamin Chun-Kit Tong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

(2017) Jakub Jeřábek et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dual inhibition of BACE1 and Aβ aggregation by β-ecdysone: Application of a phytoecdysteroid scaffold in Alzheimer’s disease therapeutics

(2017) Sandipan Chakraborty et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Multi-functional activities of citrus flavonoid narirutin in Alzheimer’s disease therapeutics: An integrated screening approach and in vitro validation

(2017) Sandipan Chakraborty et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Theory of Amyloid Fibril Nucleation from Folded Proteins

(2017) Lingyun Zhang et al.   ISRAEL JOURNAL OF CHEMISTRY

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease

(2017) Michael R. Jones et al.   Chemical Science

Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation

(2017) Christine Xue et al.   Royal Society Open Science

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment

(2017) Sergey O. Bachurin et al.   Scientific Reports

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

The Use of Stilbene Scaffold in Medicinal Chemistry and Multi- Target Drug Design

(2016) Elisa Giacomini et al.   CURRENT MEDICINAL CHEMISTRY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Multi-target screening mines hesperidin as a multi-potent inhibitor: Implication in Alzheimer's disease therapeutics

(2016) Sandipan Chakraborty et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ion Channel Formation by Amyloid-β42Oligomers but Not Amyloid-β40in Cellular Membranes

(2016) David C. Bode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrophobic tail length plays a pivotal role in amyloid beta (25-35) fibril-surfactant interactions

(2016) Sudipta Bag et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural insight into the mechanism of amyloid precursor protein recognition by β-secretase 1: A molecular dynamics study

(2015) Sandipan Chakraborty et al.   BIOPHYSICAL CHEMISTRY

Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

(2015) Jessica Nasica-Labouze et al.   CHEMICAL REVIEWS

Inhibition of β-Amyloid Aggregation by Albiflorin, Aloeemodin and Neohesperidin and their Neuroprotective Effect on Primary Hippocampal Cells Against β-Amyloid Induced Toxicity

(2015) See-Lok Ho et al.   Current Alzheimer Research

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Interfacial force-driven pattern formation during drying of Aβ (25–35) fibrils

(2015) Ayantika Sett et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Insight into the anti-amyloidogenic activity of polyphenols and its application in virtual screening of phytochemical database

(2014) Sandipan Chakraborty et al.   MEDICINAL CHEMISTRY RESEARCH

Genome-wide Association Studies in Alzheimer’s Disease: A Review

(2013) Giuseppe Tosto et al.   Current Neurology and Neuroscience Reports

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease

(2013) Valeria Capurro et al.   PLoS One

Amyloid β-Peptide 25–35 Self-Assembly and Its Inhibition: A Model Undecapeptide System to Gain Atomistic and Secondary Structure Details of the Alzheimer’s Disease Process and Treatment

(2012) Marina Naldi et al.   ACS Chemical Neuroscience

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Searching for the Multi-Target-Directed Ligands against Alzheimer’s disease: Discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities

(2011) Wenhai Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains

(2011) Cristian A. Lasagna-Reeves et al.   FEBS LETTERS

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Inclusion of chrysin in β-cyclodextrin nanocavity and its effect on antioxidant potential of chrysin: A spectroscopic and molecular modeling approach

(2010) Sandipan Chakraborty et al.   JOURNAL OF MOLECULAR STRUCTURE

Neuroprotective Effects of the Citrus Flavanones against H2O2-Induced Cytotoxicity in PC12 Cells

(2008) Sam-Long Hwang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

(2007) Lorna Piazzi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS