Article
Neurosciences
Can Sun, Jian Fu, Zhenzhen Qu, Lijing Jia, Dongxiao Li, Junli Zhen, Weiping Wang
Summary: The study found that chronic intermittent hypobaric hypoxia treatment can rescue cognitive deficits in epileptic rats by activating the Wnt/β-catenin pathway, providing a potential therapeutic approach for epilepsy-induced cognitive impairments.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yurong Wang, Yan Wang, Kai Xue, Feng Gao, Chengde Li, Hui Fang
Summary: The study showed that increased expression of Apelin-13 under chronic intermittent hypoxia conditions can reduce renal fibrosis, while inhibition of Apelin expression can exacerbate renal fibrosis. Cell experiments also demonstrated that Apelin-13 treatment can reduce oxidative stress and inflammatory response, and decrease the expression of fibrosis-related proteins.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cardiac & Cardiovascular Systems
Ziyan Wang, Yiming Zeng, Huihuang Lin
Summary: The study found that rat offspring born under conditions of chronic intermittent hypoxia in utero may develop systemic inflammation and be susceptible to artery injury, leading to intima thickening and pre-atherosclerotic lesions. Additionally, intrauterine and extrauterine CIH had interactions regarding the expression of biomarkers and intima thickness.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Immunology
Yanyan Hou, Na Xu, Shouyi Li, Na Zhang, Wenjing Ren, Zhihao Hua, Xin Zhang, Wenjian Han, Luhui Xu, Yeying Sun, Hongliu Sun, Guiwu Qu, Changjun Lv, Yan Yu
Summary: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a common sleep disorder that can lead to severe physiological disturbance. This study aimed to explore the pathological progress and potential mechanism of lung injury caused by OSAHS through a chronic intermittent hypoxia (CIH) model. The study found that CIH could induce chronic lung inflammation, promote the activation of M2 macrophages, trigger epithelial-mesenchymal transition (EMT), and accelerate the deposition of lung collagen. SMND-309 showed a protective effect on CIH-induced lung damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Liya Chen, Yao Wang, Weikun Zheng, Hu Zhang, Yan Sun, Yiping Chen, Qi Liu
Summary: This study demonstrates that intermittent hypoxia (IH) has a protective effect on the liver of high-fat and high-fructose diet (HFHFD) fed mice, attenuating lipid accumulation, lipid peroxidation, neutrophil infiltration, and apoptotic process. Additionally, IH alters bile acids composition and shifts hepatic bile acids towards FXR agonism, which contributes to the protection against HFHFD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yunfei Luo, Qiongfeng Chen, Junrong Zou, Jingjing Fan, Yuanjun Li, Zhijun Luo
Summary: This study explored the effects of hypoxia as a noninvasive and tolerable alternative treatment for obesity and nonalcoholic fatty liver disease (NAFLD). The results showed that hypoxia could alleviate bodyweight gain and insulin resistance induced by a high-fat diet, reverse enlargement of adipocytes and fatty liver, and protect liver function. Hypoxia also activated the energy sensing enzyme AMPK and increased serum levels of epinephrine, suggesting its potential therapeutic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fatima O. Martins, Joana F. Sacramento, Elena Olea, Bernardete F. Melo, Jesus Prieto-Lloret, Ana Obeso, Asuncion Rocher, Paulo Matafome, Emilia C. Monteiro, Silvia Conde
Summary: Several studies have shown a connection between obstructive sleep apnea (OSA) and insulin resistance. This study investigated the effects of chronic intermittent hypoxia (CIH) on metabolic deregulation and adipose tissue dysfunction, as well as the impact of obesity on CIH-induced metabolic disturbances. The results suggest that adipose tissue dysfunction may not be the main trigger for initial dysmetabolism in CIH.
Article
Oncology
Changjiang Ke, Yongjun Huang, Zhenyu Mao, Zhenghua Ke, Zeng Wang, Ruyou Li, Shenghua Long, Yuping Guo, Fei Wang, Meng Qian, Ruxia Zhao, Juan Zheng, Sheng Xie
Summary: This study demonstrated that calcineurin suppresses adaptive autophagy during chronic intermittent hypoxia (CIH) by downregulating AMPK activation. These findings reveal the underlying mechanism of calcineurin and autophagy regulation during H9c2 cell survival under conditions of CIH.
EXPERIMENTAL CELL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Yue Ma, Qiong Wu
Summary: There is a connection between obstructive sleep apnea syndrome (OSAS) and epilepsy, and intermittent hypoxia may be the link. Intermittent hypoxia leads to elevated levels of oxidative stress and inflammation, potentially causing inflammatory and endoplasmic reticulum stress in brain tissue, ultimately leading to the development of epilepsy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Jing Zhu, Si Tang, Dong Zhao, Zhaofu Zeng, Huaheng Mo, Ke Hu
Summary: The study found that OXA plays a positive role in cognitive impairment induced by chronic intermittent hypoxia in mice, improving cognitive function by inhibiting hippocampal apoptosis and oxidative stress.
BRAIN RESEARCH BULLETIN
(2021)
Article
Endocrinology & Metabolism
Li Zhang, Lin Jin, Jialiang Guo, Kai Bao, Jinglue Hu, Yingze Zhang, Zhiyong Hou, Liping Zhang
Summary: The study demonstrated that CIHH treatment improves fracture healing, increases bone mineral density, and enhances bone strength through the activation of HIF-1 alpha and bone production-related genes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Cancan You, Zilong Zhang, Huiya Ying, Zijing Yang, Yixuan Ma, Jingyi Hong, Mingjie Xue, Xuan Li, Huimin Li, Chengrui Zhang, Wei Wang, Xiaohong Cai, Xiucui Li
Summary: This study investigated the role of CaSR in cognitive impairment induced by obstructive sleep apnea-hypopnea syndrome (OSAHS), and revealed that it promoted hippocampal neuronal apoptosis through the PERK-ATF4-CHOP pathway. The results indicated that inhibition of CaSR could alleviate cognitive impairment caused by OSAHS.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Gaifen Li, Yuying Guan, Yakun Gu, Mengyuan Guo, Wei Ma, Qianqian Shao, Jia Liu, Xunming Ji
Summary: This study investigated the mechanism and treatment strategy for hypoxia-induced nerve injury. The researchers found that short-term hypoxia promotes neurogenesis, while long-term hypoxia inhibits neurogenesis. Intermittent hypoxic conditioning showed a neuroprotective effect by promoting neural stem cell generation and suppressing inflammation induced by long-term hypoxia stress. This study provides a new concept for the treatment of hypoxia-related brain injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Joana L. Fernandes, Fatima O. Martins, Elena Olea, Jesus Prieto-Lloret, Patricia C. Braga, Joana F. Sacramento, Catarina O. Sequeira, Ana P. Negrinho, Sofia A. Pereira, Marco G. Alves, Asuncion Rocher, Silvia V. Conde
Summary: The association between obstructive sleep apnea (OSA) and metabolic disorders is well-established, but the underlying mechanisms remain unclear. This study investigated the role of liver dysfunction in the pathogenesis of OSA-related metabolic dysfunction. The results suggest that hepatic mitochondrial dysfunction and oxidative stress, leading to inflammation, may be significant factors contributing to the development of dysmetabolism associated with OSA.
Article
Biochemistry & Molecular Biology
Richa Choudhary, Mukesh Kumar, Anju Katyal
Summary: This study investigates the mechanism of action of 12/15 lipoxygenase in high altitude cerebral edema and reveals its involvement in disruption of mitochondrial integrity and neuronal apoptosis, suggesting it as a potential therapeutic target.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.