A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

The Energetics and Physiological Impact of Cohesin Extrusion

(2018) Laura Vian et al.   CELL

Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer

(2018) Yunhua Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion

(2018) Ge Zheng et al.   eLife

Cohesin Ubiquitylation and Mobilization Facilitate Stalled Replication Fork Dynamics

(2017) Camilla Frattini et al.   MOLECULAR CELL

Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl

(2017) Georg A. Busslinger et al.   NATURE

Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1

(2017) Lorena Benedetti et al.   Oncotarget

Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

(2017) Petra van der Lelij et al.   eLife

Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma

(2016) Che-Hung Shen et al.   NATURE MEDICINE

Global transcriptional disturbances underlie Cornelia de Lange syndrome and related phenotypes

(2015) Bo Yuan et al.   JOURNAL OF CLINICAL INVESTIGATION

Cohesin’s ATPase Activity Couples Cohesin Loading onto DNA with Smc3 Acetylation

(2014) Rene Ladurner et al.   CURRENT BIOLOGY

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

The Genomic Landscape of Pediatric Ewing Sarcoma

(2014) B. D. Crompton et al.   Cancer Discovery

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

(2014) F. Tirode et al.   Cancer Discovery

The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation

(2014) Andrew S. Brohl et al.   PLoS Genetics

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

(2013) Ayana Kon et al.   NATURE GENETICS

Frequent truncating mutations of STAG2 in bladder cancer

(2013) David A Solomon et al.   NATURE GENETICS

Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy

(2013) Cristina Balbás-Martínez et al.   NATURE GENETICS

RAD21 Mutations Cause a Human Cohesinopathy

(2012) Matthew A. Deardorff et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cohesin’s DNA Exit Gate Is Distinct from Its Entrance Gate and Is Regulated by Acetylation

(2012) Kok-Lung Chan et al.   CELL

Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres

(2012) Silvia Remeseiro et al.   EMBO JOURNAL

Cohesin Association to Replication Sites Depends on Rad50 and Promotes Fork Restart

(2012) Mireille Tittel-Elmer et al.   MOLECULAR CELL

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

(2012) Matthew A. Deardorff et al.   NATURE

Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators

(2012) Jessica L. McLellan et al.   PLoS Genetics

Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

(2011) D. A. Solomon et al.   SCIENCE

Cohesin organizes chromatin loops at DNA replication factories

(2010) E. Guillou et al.   GENES & DEVELOPMENT

An Smc3 Acetylation Cycle Is Essential for Establishment of Sister Chromatid Cohesion

(2010) Frederic Beckouët et al.   MOLECULAR CELL

Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells

(2009) Silvia Canudas et al.   JOURNAL OF CELL BIOLOGY

Cohesin acetylation speeds the replication fork

(2009) Marie-Emilie Terret et al.   NATURE

Transcriptional Dysregulation in NIPBL and Cohesin Mutant Human Cells

(2009) Jinglan Liu et al.   PLOS BIOLOGY

Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms

(2008) Vania Parelho et al.   CELL

The cohesin ring concatenates sister DNA molecules

(2008) Christian H. Haering et al.   NATURE

Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion

(2008) T. R. Ben-Shahar et al.   SCIENCE