Fibrosis Regression After Eradication of Hepatitis C Virus: From Bench to Bedside

Identification of Lineage-specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution

(2020) Xiao Liu et al.   GASTROENTEROLOGY

High serum angiopoietin‐2 level predicts non‐regression of liver stiffness measurement‐based liver fibrosis stage after direct‐acting antiviral therapy for hepatitis C

(2020) Naoki Kawagishi et al.   HEPATOLOGY RESEARCH

Review article: the signalling and functional role of the extracellular matrix in the development of liver fibrosis

(2020) Ida Falk Villesen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Why do so many NASH trials fail?

(2020) Vlad Ratziu et al.   GASTROENTEROLOGY

1006 PREDICTORS OF POOR FIBROSIS REGRESSION AFTER DIRECT ACTING ANTIVIRAL THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C AND CIRRHOSIS

(2020) Shaurya Prakash et al.   GASTROENTEROLOGY

Hepatic fibrosis: A convergent response to liver injury that is reversible

(2020) Shuang Wang et al.   JOURNAL OF HEPATOLOGY

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Association of Direct-Acting Antiviral Treatment With Mortality Among Medicare Beneficiaries With Hepatitis C

(2020) Yamini Kalidindi et al.   JAMA Network Open

Non-invasive assessment of liver fibrosis and prognosis: an update on serum and elastography markers

(2019) Uchenna Agbim et al.   Expert Review of Gastroenterology & Hepatology

AGA Clinical Practice Update on Interaction between Oral Direct-Acting Antivirals (DAAs) for Chronic Hepatitis C Infection and Hepatocellular Carcinoma: Expert Review

(2019) Amit G. Singal et al.   GASTROENTEROLOGY

Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis

(2019) Anissa A. Widjaja et al.   GASTROENTEROLOGY

Long-term treatment with recombinant human pentraxin 2 protein in patients with idiopathic pulmonary fibrosis: an open-label extension study

(2019) Ganesh Raghu et al.   Lancet Respiratory Medicine

Changes in HVPG predict hepatic decompensation in patients who achieved SVR to IFN ‐free therapy

(2019) Mattias Mandorfer et al.   HEPATOLOGY

Lipophilic Statins and Risk for Hepatocellular Carcinoma and Death in Patients With Chronic Viral Hepatitis: Results From a Nationwide Swedish Population

(2019) Tracey G. Simon et al.   ANNALS OF INTERNAL MEDICINE

A novel deactivation factor of fibrogenic hepatic stellate cells induces regression of liver fibrosis in mice

(2019) Yasuhiro Nakano et al.   HEPATOLOGY

Sustained virological response from interferon-based hepatitis C regimens is associated with reduced risk of extrahepatic manifestations

(2019) Carmine Rossi et al.   JOURNAL OF HEPATOLOGY

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

Hepatitis C eradication with direct-acting anti-virals reduces the risk of variceal bleeding

(2019) Andrew M. Moon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Noninvasive Measurements Predict Liver Fibrosis Well in Hepatitis C Virus Patients After Direct-Acting Antiviral Therapy

(2019) Rui Huang et al.   DIGESTIVE DISEASES AND SCIENCES

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Safety profile of autologous macrophage therapy for liver cirrhosis

(2019) Francesca Moroni et al.   NATURE MEDICINE

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

(2019) Ross Dobie et al.   Cell Reports

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases

(2019) Daphne van der Heide et al.   Frontiers in Immunology

Hepatic stellate cells retain retinoid-laden lipid droplets after cellular transdifferentiation into activated myofibroblasts

(2018) Loretta L Jophlin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Magnitude and Kinetics of Decrease in Liver Stiffness After Antiviral Therapy in Patients With Chronic Hepatitis C: A Systematic Review and Meta-analysis

(2018) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Treatment of hepatitis C with direct-acting antivirals significantly reduces liver-related hospitalizations in patients with cirrhosis

(2018) Lucas A. Hill et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Simtuzumab Is Ineffective for Patients with Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis

(2018) Stephen A. Harrison et al.   GASTROENTEROLOGY

Incidence of Hepatocellular Carcinoma in Patients With HCV-Associated Cirrhosis Treated With Direct-Acting Antiviral Agents

(2018) Vincenza Calvaruso et al.   GASTROENTEROLOGY

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

(2018) Scott L. Friedman et al.   HEPATOLOGY

Portal pressure and liver stiffness measurements in the prediction of fibrosis regression after sustained virological response in recurrent hepatitis C

(2018) Ezequiel Mauro et al.   HEPATOLOGY

Effect of Recombinant Human Pentraxin 2 vs Placebo on Change in Forced Vital Capacity in Patients With Idiopathic Pulmonary Fibrosis

(2018) Ganesh Raghu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Eradication of hepatitis C virus in patients with decompensated cirrhosis does not improve the management of ascites after one year of follow-up

(2018) A. Juanola et al.   JOURNAL OF HEPATOLOGY

The risk of hepatocellular carcinoma in cirrhotic patients with hepatitis C and sustained viral response: Role of the treatment regimen

(2018) Hamish Innes et al.   JOURNAL OF HEPATOLOGY

Pharmacotherapy for NASH: Current and emerging

(2018) Monica A. Konerman et al.   JOURNAL OF HEPATOLOGY

Newly diagnosed hepatocellular carcinoma in patients with advanced hepatitis C treated with DAAs: A prospective population study

(2018) Antonietta Romano et al.   JOURNAL OF HEPATOLOGY

Development of a novel clinical staging model for cirrhosis using the Nationwide Inpatient Sample

(2018) Mona Haj et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Decreasing mortality and disease severity in hepatitis C patients awaiting liver transplantation in the United States

(2018) Allison Kwong et al.   LIVER TRANSPLANTATION

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Assessment of Liver Fibrosis Progression and Regression by a Serological Collagen Turnover Profile

(2018) Morten Asser Karsdal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Reversibility of Schistosomal Periportal Thickening/Fibrosis after Praziquantel Therapy: A Twenty-Six Month Follow-up Study in Ethiopia

(2018) Nega Berhe et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Complete Resolution of Nonalcoholic Fatty Liver Disease After Bariatric Surgery: A Systematic Review and Meta-Analysis

(2018) Yung Lee et al.   Clinical Gastroenterology and Hepatology

What Are the Benefits of a Sustained Virologic Response to Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection?

(2018) George N. Ioannou et al.   GASTROENTEROLOGY

Wnt–β-catenin signalling in liver development, health and disease

(2018) Maria J. Perugorria et al.   Nature Reviews Gastroenterology & Hepatology

American Gastroenterological Association Institute Guideline on the Role of Elastography in the Evaluation of Liver Fibrosis

(2017) Joseph K. Lim et al.   GASTROENTEROLOGY

Effects of All-Oral Anti-Viral Therapy on HVPG and Systemic Hemodynamics in Patients With Hepatitis C Virus-Associated Cirrhosis

(2017) Sabela Lens et al.   GASTROENTEROLOGY

Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces Risk of Liver and Non-Liver Complications

(2017) Pierre Nahon et al.   GASTROENTEROLOGY

American Gastroenterological Association Institute Technical Review on the Role of Elastography in Chronic Liver Diseases

(2017) Siddharth Singh et al.   GASTROENTEROLOGY

Persisting risk of hepatocellular carcinoma after hepatitis C virus cure monitored by a liver transcriptome signature

(2017) Atsushi Ono et al.   HEPATOLOGY

Risk of end-stage liver disease, hepatocellular carcinoma, and liver-related death by fibrosis stage in the hepatitis C Alaska Cohort

(2017) Dana J.T. Bruden et al.   HEPATOLOGY

Risk of cirrhosis-related complications in patients with advanced fibrosis following hepatitis C virus eradication

(2017) Adriaan J. van der Meer et al.   JOURNAL OF HEPATOLOGY

Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD

(2017) Hannes Hagström et al.   JOURNAL OF HEPATOLOGY

The risk of early occurrence and recurrence of hepatocellular carcinoma in hepatitis C-infected patients treated with direct-acting antivirals with and without pegylated interferon: A Belgian experience

(2017) R. Bielen et al.   JOURNAL OF VIRAL HEPATITIS

Upregulation of the actin cytoskeleton via myocardin leads to increased expression of type 1 collagen

(2017) Zengdun Shi et al.   LABORATORY INVESTIGATION

IFN-λ3, not IFN-λ4, likely mediates IFNL3–IFNL4 haplotype–dependent hepatic inflammation and fibrosis

(2017) Mohammed Eslam et al.   NATURE GENETICS

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes

(2017) Li Bai et al.   Scientific Reports

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Serum Biomarkers Indicate Long-term Reduction in Liver Fibrosis in Patients With Sustained Virological Response to Treatment for HCV Infection

(2016) Mei Lu et al.   Clinical Gastroenterology and Hepatology

Effects of Eradicating Hepatitis C Virus Infection in Patients With Cirrhosis Differ With Stage of Portal Hypertension

(2016) Vito Di Marco et al.   GASTROENTEROLOGY

Reduction in liver transplant wait-listing in the era of direct-acting antiviral therapy

(2016) Jennifer A. Flemming et al.   HEPATOLOGY

Early occurrence and recurrence of hepatocellular carcinoma in HCV-related cirrhosis treated with direct-acting antivirals

(2016) Fabio Conti et al.   JOURNAL OF HEPATOLOGY

Delisting of liver transplant candidates with chronic hepatitis C after viral eradication: A European study

(2016) Luca Saverio Belli et al.   JOURNAL OF HEPATOLOGY

Sustained virologic response to interferon-free therapies ameliorates HCV-induced portal hypertension

(2016) Mattias Mandorfer et al.   JOURNAL OF HEPATOLOGY

Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis

(2016) Graham R. Foster et al.   JOURNAL OF HEPATOLOGY

Survival of patients with HCV cirrhosis and sustained virologic response is similar to the general population

(2016) Savino Bruno et al.   JOURNAL OF HEPATOLOGY

Regression of fibrosis and portal hypertension in HCV-associated cirrhosis and sustained virologic response after interferon-free antiviral therapy

(2016) V. Knop et al.   JOURNAL OF VIRAL HEPATITIS

Impact of viral eradication with sofosbuvir-based therapy on the outcome of post-transplant hepatitis C with severe fibrosis

(2016) Silvia Martini et al.   LIVER INTERNATIONAL

Direct antiviral agent treatment of chronic hepatitis C results in rapid regression of transient elastography and fibrosis markers fibrosis-4 score and aspartate aminotransferase-platelet ratio index

(2016) Jacqueline A. Bachofner et al.   LIVER INTERNATIONAL

Liver regeneration — mechanisms and models to clinical application

(2016) Stuart J. Forbes et al.   Nature Reviews Gastroenterology & Hepatology

Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis

(2016) Eric Lefebvre et al.   PLoS One

Novel insights into the function and dynamics of extracellular matrix in liver fibrosis

(2015) Morten A. Karsdal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Fibrosis Regression Explains Differences in Outcome in HIV-/HCV-Coinfected Patients with Cirrhosis After Sustained Virological Response

(2015) José Luis Casado et al.   DIGESTIVE DISEASES AND SCIENCES

Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage

(2015) C. Mogler et al.   EMBO Molecular Medicine

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

(2015) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Resetting the transcription factor network reverses terminal chronic hepatic failure

(2015) Taichiro Nishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of fibrosis progression on clinical outcome in patients treated for post- transplant hepatitis C recurrence

(2015) Renumathy Dhanasekaran et al.   LIVER INTERNATIONAL

Fibrosis — A Common Pathway to Organ Injury and Failure

(2015) Don C. Rockey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resolution of Liver Fibrosis: Basic Mechanisms and Clinical Relevance

(2015) Prakash Ramachandran et al.   SEMINARS IN LIVER DISEASE

Mesothelin-Targeted CARs: Driving T Cells to Solid Tumors

(2015) A. Morello et al.   Cancer Discovery

Systematic review: the effects of autologous stem cell therapy for patients with liver disease

(2014) J. K. Moore et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Reversal, maintenance or progression: What happens to the liver after a virologic cure of hepatitis C?

(2014) Youngmin A. Lee et al.   ANTIVIRAL RESEARCH

Stem/Progenitor Cells in Liver Development, Homeostasis, Regeneration, and Reprogramming

(2014) Atsushi Miyajima et al.   Cell Stem Cell

Identifying Molecular Factors That Contribute to Resolution of Liver Fibrosis

(2014) John P. Iredale et al.   GASTROENTEROLOGY

Impact of common risk factors of fibrosis progression in chronic hepatitis C

(2014) S Rüeger et al.   GUT

KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins

(2014) Giusi Marrone et al.   GUT

Activated Hepatic Stellate Cells Are Dependent on Self-collagen, Cleaved by Membrane Type 1 Matrix Metalloproteinase for Their Growth

(2014) Naoko Kubo Birukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brief Communication: The Relationship of Regression of Cirrhosis to Outcome in Chronic Hepatitis C

(2013) Vincent Mallet et al.   ANNALS OF INTERNAL MEDICINE

Eradication of Hepatitis C Virus Infection and the Development of Hepatocellular Carcinoma

(2013) Rebecca L. Morgan et al.   ANNALS OF INTERNAL MEDICINE

Translating an Understanding of the Pathogenesis of Hepatic Fibrosis to Novel Therapies

(2013) Don C. Rockey   Clinical Gastroenterology and Hepatology

Association Between Sustained Virological Response and All-Cause Mortality Among Patients With Chronic Hepatitis C and Advanced Hepatic Fibrosis

(2013) Adriaan J. van der Meer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Slow regression of liver fibrosis presumed by repeated biomarkers after virological cure in patients with chronic hepatitis C

(2013) Thierry Poynard et al.   JOURNAL OF HEPATOLOGY

Reversal of cirrhosis: An achievable goal of hepatitis B antiviral therapy

(2013) Yun-Fan Liaw   JOURNAL OF HEPATOLOGY

Antiviral therapy of symptomatic HCV-associated mixed cryoglobulinemia: Meta-analysis of clinical studies

(2013) Fabrizio Fabrizi et al.   JOURNAL OF MEDICAL VIROLOGY

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

Measuring the Global Burden of Disease

(2013) Christopher J.L. Murray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease

(2013) Peter G. Traber et al.   PLoS One

Course of Liver Fibrosis in HIV-Hepatitis C Virus-Coinfected Patients Depending on the Response to Hepatitis C Therapy

(2012) José-Antonio Cartón et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Autophagy fuels tissue fibrogenesis

(2012) Virginia Hernández-Gea et al.   Autophagy

Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation

(2012) John P. Iredale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

A morphometric and immunohistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis

(2012) Roberta D'Ambrosio et al.   HEPATOLOGY

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study

(2012) Patrick Marcellin et al.   LANCET

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

(2011) Abby L. Olsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Galectin-3 modulates phagocytosis-induced stellate cell activation and liver fibrosis in vivo

(2011) Joy X. Jiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Tissue Transglutaminase Does Not Affect Fibrotic Matrix Stability or Regression of Liver Fibrosis in Mice

(2011) Yury Popov et al.   GASTROENTEROLOGY

A role for autophagy during hepatic stellate cell activation

(2011) Lien F.R. Thoen et al.   JOURNAL OF HEPATOLOGY

Renal failure and cirrhosis: A systematic review of mortality and prognosis

(2011) Giuseppe Fede et al.   JOURNAL OF HEPATOLOGY

PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosis

(2010) J.S. Duffield et al.   DRUG NEWS & PERSPECTIVES

Infections in Patients With Cirrhosis Increase Mortality Four-Fold and Should Be Used in Determining Prognosis

(2010) Vasiliki Arvaniti et al.   GASTROENTEROLOGY

Sustained virologic response prevents the development of esophageal varices in compensated, Child-Pugh class A hepatitis C virus-induced cirrhosis. A 12-year prospective follow-up study

(2010) Savino Bruno et al.   HEPATOLOGY

Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B

(2010) Ting-Tsung Chang et al.   HEPATOLOGY

Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells

(2010) Jonel Trebicka et al.   JOURNAL OF HEPATOLOGY

Evolution of the Pentraxin Family: The New Entry PTX4

(2010) Y. Martinez de la Torre et al.   JOURNAL OF IMMUNOLOGY

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Farglitazar Lacks Antifibrotic Activity in Patients With Chronic Hepatitis C Infection

(2009) John McHutchison et al.   GASTROENTEROLOGY

Fibrosis progression in chronic hepatitis C: Morphometric image analysis in the HALT-C trial

(2009) Zachary D. Goodman et al.   HEPATOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Serum Amyloid P Inhibits Fibrosis Through Fc R-Dependent Monocyte-Macrophage Regulation in Vivo

(2009) A. P. Castano et al.   Science Translational Medicine

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Partial Hepatectomy–Induced Regeneration Accelerates Reversion of Liver Fibrosis Involving Participation of Hepatic Stellate Cells

(2008) Juan A. Suárez-Cuenca et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Noninvasive Assessment of Liver Fibrosis and Portal Hypertension With Transient Elastography

(2008) Don C. Rockey   GASTROENTEROLOGY

Eradication of Hepatitis C Virus in Patients Successfully Treated for Chronic Hepatitis C

(2008) Sarah Maylin et al.   GASTROENTEROLOGY

Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence

(2008) Laurie D. DeLeve et al.   HEPATOLOGY

Liver biopsy

(2008) Don C. Rockey et al.   HEPATOLOGY

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

(2008) Yujin Hoshida et al.   NEW ENGLAND JOURNAL OF MEDICINE