WEE1 inhibition reverses trastuzumab resistance in HER2-positive cancers

Detection of pancreatic ductal adenocarcinoma with galectin-9 serum levels

(2020) Adrian M. Seifert et al.   ONCOGENE

Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis

(2020) Yaqing Zhang et al.   Cancer Discovery

Natural killer cells in cancer biology and therapy

(2020) Song-Yang Wu et al.   Molecular Cancer

The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy

(2019) Fernando Souza-Fonseca-Guimaraes et al.   TRENDS IN IMMUNOLOGY

Pembrolizumab plus trastuzumab in trastuzumab-resistant, advanced, HER2-positive breast cancer (PANACEA): a single-arm, multicentre, phase 1b–2 trial

(2019) Sherene Loi et al.   LANCET ONCOLOGY

GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation

(2019) Michael Dougan et al.   IMMUNITY

PD-L1 (B7-H1) Competes with the RNA Exosome to Regulate the DNA Damage Response and Can Be Targeted to Sensitize to Radiation or Chemotherapy

(2019) Xinyi Tu et al.   MOLECULAR CELL

Resistance mechanisms to anti-HER2 therapies in HER2-positive breast cancer: Current knowledge, new research directions and therapeutic perspectives

(2019) Claudio Vernieri et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Therapeutic Co-targeting of WEE1 and ATM Downregulates PD-L1 Expression in Pancreatic Cancer

(2019) Mei Hua Jin et al.   Cancer Research and Treatment

HER2-targeted therapies — a role beyond breast cancer

(2019) Do-Youn Oh et al.   Nature Reviews Clinical Oncology

Blockade of ErbB2 and PD-L1 using a bispecific antibody to improve targeted anti-ErbB2 therapy

(2019) Deepak Mittal et al.   OncoImmunology

Quantitative Assessment of CMTM6 in the Tumor Microenvironment and Association with Response to PD-1 Pathway Blockade in Advanced-Stage Non–Small Cell Lung Cancer

(2019) Jon Zugazagoitia et al.   Journal of Thoracic Oncology

Trastuzumab upregulates PD-L1 as a potential mechanism of trastuzumab resistance through engagement of immune effector cells and stimulation of IFNγ secretion

(2018) Bharat K.R. Chaganty et al.   CANCER LETTERS

Incidence and Overall Survival of Biliary Tract Cancers in South Korea from 2006 to 2015: Using the National Health Information Database

(2018) Byung-Woo Kim et al.   Gut and Liver

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint

(2018) Xiaoting Lin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Trastuzumab-Resistant HER2+Breast Cancer Cells Retain Sensitivity to Poly (ADP-Ribose) Polymerase (PARP) Inhibition

(2018) Monica E. Wielgos et al.   MOLECULAR CANCER THERAPEUTICS

Genetic, transcriptional and post-translational regulation of the programmed death protein ligand 1 in cancer: biology and clinical correlations

(2018) Ioannis Zerdes et al.   ONCOGENE

Antagonizing CD105 enhances radiation sensitivity in prostate cancer

(2018) Anisha Madhav et al.   ONCOGENE

Regulation of PD-L1: Emerging Routes for Targeting Tumor Immune Evasion

(2018) Yiting Wang et al.   Frontiers in Pharmacology

Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies

(2018) Jay Friedman et al.   Journal for ImmunoTherapy of Cancer

Targeting Programmed Cell Death -1 (PD-1) and Ligand (PD-L1): A new era in cancer active immunotherapy

(2018) Anastasia Constantinidou et al.   PHARMACOLOGY & THERAPEUTICS

WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy

(2018) Lillian Sun et al.   OncoImmunology

CMTM6 overexpression is associated with molecular and clinical characteristics of malignancy and predicts poor prognosis in gliomas

(2018) Xiudong Guan et al.   EBioMedicine

Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy

(2018) Jinfang Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer

(2018) Marta Helena Kubala et al.   Cell Reports

Resistance Mechanism against Trastuzumab in HER2-Positive Cancer Cells and Its Negation by Src Inhibition

(2017) Mei Hua Jin et al.   MOLECULAR CANCER THERAPEUTICS

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

(2017) Marian L. Burr et al.   NATURE

TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis

(2017) Y Zhou et al.   ONCOGENE

Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression

(2017) Xiulan Liu et al.   Cell Death & Disease

Gastric cancer

(2016) Eric Van Cutsem et al.   LANCET

Targeting WEE1 Kinase in Cancer

(2016) Christopher J. Matheson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Therapeutic implication of HER2 in advanced biliary tract cancer

(2016) Ah-Rong Nam et al.   Oncotarget

Regulation of PD-L1: a novel role of pro-survival signalling in cancer

(2015) J. Chen et al.   ANNALS OF ONCOLOGY

Targeted Therapy in Biliary Tract Cancers

(2015) Amartej Merla et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

(2015) Patricia Marti et al.   HEPATOLOGY

Genomic spectra of biliary tract cancer

(2015) Hiromi Nakamura et al.   NATURE GENETICS

Interaction of CDCP1 with HER2 Enhances HER2-Driven Tumorigenesis and Promotes Trastuzumab Resistance in Breast Cancer

(2015) Abdullah Alajati et al.   Cell Reports

Poly (ADP-ribose) polymerase inhibition enhances trastuzumab antitumour activity in HER2 overexpressing breast cancer

(2014) Jetzabel García-Parra et al.   EUROPEAN JOURNAL OF CANCER

DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints

(2010) Zhongsheng You et al.   TRENDS IN CELL BIOLOGY

HER2 in gastric cancer: a new prognostic factor and a novel therapeutic target

(2008) C. Gravalos et al.   ANNALS OF ONCOLOGY