An analysis of inhibition of the severe acute respiratory syndrome coronavirus 2 RNA-dependent RNA polymerase by zinc ion: an in silico approach

Anti-HCV, nucleotide inhibitors, repurposing against COVID-19

(2020) Abdo A. Elfiky   LIFE SCIENCES

Structural basis for RNA replication by the SARS-CoV-2 polymerase

(2020) Quan Wang et al.   CELL

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

Potential Role of Zinc Supplementation in Prophylaxis and Treatment of COVID-19

(2020) Amit Kumar et al.   MEDICAL HYPOTHESES

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

(2020) Wanchao Yin et al.   SCIENCE

Progress and Prospects on Vaccine Development against SARS-CoV-2

(2020) Jinyong Zhang et al.   Vaccines

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

(2020) Ashleigh Shannon et al.   ANTIVIRAL RESEARCH

A Hypothesis for the Possible Role of Zinc in the Immunological Pathways Related to COVID-19 Infection

(2020) Ander Mayor-Ibarguren et al.   Frontiers in Immunology

Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2

(2020) Muhammad Arba et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

(2018) Maria L. Agostini et al.   mBio

Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase

(2017) Nidhi Kaushik et al.   JOURNAL OF VIROLOGY

Protein conformational flexibility modulates kinetics and thermodynamics of drug binding

(2017) M. Amaral et al.   Nature Communications

MIB: Metal Ion-Binding Site Prediction and Docking Server

(2016) Yu-Feng Lin et al.   Journal of Chemical Information and Modeling

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

DelPhi Web Server: A Comprehensive Online Suite for Electrostatic Calculations of Biological Macromolecules and Their Complexes

(2016) Subhra Sarkar et al.   Communications in Computational Physics

NGL Viewer: a web application for molecular visualization

(2015) Alexander S. Rose et al.   NUCLEIC ACIDS RESEARCH

Structural basis for RNA replication by the hepatitis C virus polymerase

(2015) T. C. Appleby et al.   SCIENCE

3Dmol.js: molecular visualization with WebGL

(2014) N. Rego et al.   BIOINFORMATICS

CDD: NCBI's conserved domain database

(2014) Aron Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

(2014) Lorenzo Subissi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc ion coordination as a modulating factor of the ZnuA histidine-rich loop flexibility: A molecular modeling and fluorescence spectroscopy study

(2012) Silvia Castelli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DelPhi web server v2: incorporating atomic-style geometrical figures into the computational protocol

(2012) Nicholas Smith et al.   BIOINFORMATICS

Prediction of Metal Ion–Binding Sites in Proteins Using the Fragment Transformation Method

(2012) Chih-Hao Lu et al.   PLoS One

Antiviral activity of zinc salts against transmissible gastroenteritis virus in vitro

(2012) Zhanyong Wei et al.   VETERINARY MICROBIOLOGY

The Intrinsic Protein Flexibility of Endogenous Protease Inhibitor TIMP-1 Controls Its Binding Interface and Affects Its Function

(2010) Moran Grossman et al.   BIOCHEMISTRY

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

(2010) P. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Essential Toxin: Impact of Zinc on Human Health

(2010) Laura M. Plum et al.   International Journal of Environmental Research and Public Health

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

(2010) Aartjan J. W. te Velthuis et al.   PLoS Pathogens

The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent

(2009) Aartjan J. W. te Velthuis et al.   NUCLEIC ACIDS RESEARCH

Antiviral Activity of the Zinc Ionophores Pyrithione and Hinokitiol against Picornavirus Infections

(2008) B. M. Krenn et al.   JOURNAL OF VIROLOGY