Targeting SLC3A2 subunit of system XC− is essential for m6A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma

TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress

(2021) Susu Guo et al.   Cell Death & Disease

Identification of Frataxin as a regulator of ferroptosis

(2020) Jing Du et al.   Redox Biology

High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11)

(2020) Itsuki Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation

(2020) Chuanzhao Zhang et al.   ONCOGENE

TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells

(2020) Do Hyung Kim et al.   Cell Death & Disease

Integrative Proteomic Characterization of Human Lung Adenocarcinoma

(2020) Jun-Yu Xu et al.   CELL

LEAD‐m6A‐seq for Locus‐specific Detection of N6‐methyladenosine and Quantification of Differential Methylation

(2020) Chuan He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

xCT: A Critical Molecule That Links Cancer Metabolism to Redox Signaling

(2020) Jinyun Liu et al.   MOLECULAR THERAPY

The Latest View on the Mechanism of Ferroptosis and Its Research Progress in Spinal Cord Injury

(2020) Yixin Chen et al.   Oxidative Medicine and Cellular Longevity

Tumor organoid models in precision medicine and investigating cancer-stromal interactions

(2020) Ren Xu et al.   PHARMACOLOGY & THERAPEUTICS

Downregulation of m 6 A reader YTHDC2 promotes tumor progression and predicts poor prognosis in non‐small cell lung cancer

(2020) Shulei Sun et al.   Thoracic Cancer

Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer

(2020) Ji-Yoon Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The m6A reader protein YTHDC2 is a potential biomarker and associated with immune infiltration in head and neck squamous cell carcinoma

(2020) Yang Li et al.   PeerJ

The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function

(2020) Lifang Ma et al.   Redox Biology

The Critical Role of RNA m6A Methylation in Cancer

(2019) Qing Lan et al.   CANCER RESEARCH

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma

(2019) Jake June-Koo Lee et al.   CELL

Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome

(2019) Konstantinos Boulias et al.   MOLECULAR CELL

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail

(2019) Xinyao Lin et al.   Nature Communications

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks

(2019) Judit Domingo-Prim et al.   Nature Communications

IFN-γ down-regulates the PD-1 expression and assist nivolumab in PD-1-blockade effect on CD8+ T-lymphocytes in pancreatic cancer

(2019) Guoping Ding et al.   BMC CANCER

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

(2019) Yuanhui Mao et al.   Nature Communications

YTHDF2 Recognition of N1-Methyladenosine (m1A)-Modified RNA Is Associated with Transcript Destabilization

(2019) Kyung W. Seo et al.   ACS Chemical Biology

Prominin-2 Suppresses Ferroptosis Sensitivity

(2019) Alexia Belavgeni et al.   DEVELOPMENTAL CELL

xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression

(2018) Xiangming Ji et al.   ONCOGENE

The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′-3′ exoribonuclease XRN1

(2018) Jens Kretschmer et al.   RNA

Reading m 6 A in the Transcriptome: m 6 A-Binding Proteins

(2018) Deepak P. Patil et al.   TRENDS IN CELL BIOLOGY

Downregulation of HOXA13 sensitizes human esophageal squamous cell carcinoma to chemotherapy

(2018) Qi Shi et al.   Thoracic Cancer

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

High expression of HOXA13 correlates with poorly differentiated hepatocellular carcinomas and modulates sorafenib response in in vitro models

(2017) Luca Quagliata et al.   LABORATORY INVESTIGATION

Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells

(2017) Deng-Chyang Wu et al.   STEM CELLS

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

In vitro models of medulloblastoma: Choosing the right tool for the job

(2016) Delyan P. Ivanov et al.   JOURNAL OF BIOTECHNOLOGY

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

miR-10b-5p expression in Huntington’s disease brain relates to age of onset and the extent of striatal involvement

(2015) Andrew G Hoss et al.   BMC Medical Genomics

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

RNA degradation paths in a 12-subunit nuclear exosome complex

(2015) Debora Lika Makino et al.   NATURE

Expression of xCT and activity of system x c − are regulated by NRF2 in human breast cancer cells in response to oxidative stress

(2015) Eric Habib et al.   Redox Biology

IGF-I Regulates Redox Status in Breast Cancer Cells by Activating the Amino Acid Transport Molecule xC−

(2014) Yuzhe Yang et al.   CANCER RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

HOXA13 Promotes Cancer Cell Growth and Predicts Poor Survival of Patients with Esophageal Squamous Cell Carcinoma

(2009) Z.-D. Gu et al.   CANCER RESEARCH