Mechanisms underlying the hormetic effect of conjugated linoleic acid: Focus on Nrf2, mitochondria and NADPH oxidases

The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond

(2021) Rami Mosaoa et al.   Biomolecules

Improvement of NRF2 gene expression and antioxidant status in patients with type 2 diabetes mellitus after supplementation with omega-3 polyunsaturated fatty acids: A double-blind randomised placebo-controlled clinical trial

(2020) Pegah Golpour et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

(2020) Ze Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic drivers of non-alcoholic fatty liver disease

(2020) Kendra K. Bence et al.   Molecular Metabolism

Past, present and future perspectives in nonalcoholic fatty liver disease

(2019) Arun J. Sanyal   Nature Reviews Gastroenterology & Hepatology

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

(2019) Artem P. Gureev et al.   Frontiers in Genetics

Dietary Supplementation with Fish Oil or Conjugated Linoleic Acid Relieves Depression Markers in Mice by Modulation of the Nrf2 Pathway

(2019) Luisa Cigliano et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells

(2019) Bhavana Chhunchha et al.   Cells

Crosstalk between mitochondrial metabolism and oxidoreductive homeostasis: a new perspective for understanding the effects of bioactive dietary compounds

(2019) Mariangela Di Giacomo et al.   NUTRITION RESEARCH REVIEWS

Pentose phosphate pathway activity parallels lipogenesis but not antioxidant processes in rat liver

(2018) Eunsook S. Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease

(2018) Misaki Matsumoto et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oleanolic acid reprograms the liver to protect against hepatotoxicants, but is hepatotoxic at high doses

(2018) Jie Liu et al.   LIVER INTERNATIONAL

Hepatic mitochondrial defects in a mouse model of NAFLD are associated with increased degradation of oxidative phosphorylation subunits.

(2018) Kwangwon Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria

(2018) In-geun Ryoo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators

(2018) Elena Piccinin et al.   Nature Reviews Gastroenterology & Hepatology

Conjugated linoleic acid prevents age-dependent neurodegeneration in a mouse model of neuropsychiatric lupus via the activation of an adaptive response

(2017) Antonio Monaco et al.   JOURNAL OF LIPID RESEARCH

Oxidative stress and antioxidants: Distress or eustress ?

(2016) Etsuo Niki   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an in vivo gene knockout study

(2016) Yanyan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals

(2016) Si Qin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Conjugated Linoleic Acid: Potential Health Benefits as a Functional Food Ingredient

(2016) Jun Ho Kim et al.   Annual Review of Food Science and Technology

Dietary trans-10, cis-12-conjugated linoleic acid alters fatty acid metabolism and microbiota composition in mice

(2015) Tatiana M. Marques et al.   BRITISH JOURNAL OF NUTRITION

Pros and cons of CLA consumption: an insight from clinical evidences

(2015) Sailas Benjamin et al.   Nutrition & Metabolism

Krill Oil Ameliorates Mitochondrial Dysfunctions in Rats Treated with High-Fat Diet

(2015) Alessandra Ferramosca et al.   Biomed Research International

The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.

(2015) Olga Catalina-Rodriguez et al.   Oncotarget

c9,t11-Conjugated linoleic acid ameliorates steatosis by modulating mitochondrial uncoupling and Nrf2 pathway

(2014) Maria Pina Mollica et al.   JOURNAL OF LIPID RESEARCH

Nrf2 Amplifies Oxidative Stress via Induction of Klf9

(2014) Shoshanna N. Zucker et al.   MOLECULAR CELL

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Modulation of hepatic steatosis by dietary fatty acids

(2014) Alessandra Ferramosca   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary Fat and Hepatic Lipogenesis: Mitochondrial Citrate Carrier as a Sensor of Metabolic Changes

(2014) Alessandra Ferramosca et al.   Advances in Nutrition

Free radical biology for medicine: learning from nonalcoholic fatty liver disease

(2013) Gaetano Serviddio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications

(2012) Kenneth Cusi   GASTROENTEROLOGY

Glucose-6-phosphate dehydrogenase, NADPH, and cell survival

(2012) Robert C. Stanton   IUBMB LIFE

High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet

(2012) Günther Silbernagel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nonalcoholic Fatty Liver Disease: Pathologic Patterns and Biopsy Evaluation in Clinical Research

(2012) David Kleiner et al.   SEMINARS IN LIVER DISEASE

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

(2011) Tohru Fukai et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Regulation of Mitochondrial Function

(2011) Diane E. Handy et al.   ANTIOXIDANTS & REDOX SIGNALING

Dietary n-3 Polyunsaturated Fatty Acids and the Paradox of Their Health Benefits and Potential Harmful Effects

(2011) Simona Serini et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The control of mitochondrial succinate-dependent H2O2 production

(2011) Franco Zoccarato et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Reactive Oxygen Species Production by Forward and Reverse Electron Fluxes in the Mitochondrial Respiratory Chain

(2011) Vitaly A. Selivanov et al.   PLoS Computational Biology

Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease

(2010) R. N. Hardwick et al.   DRUG METABOLISM AND DISPOSITION

Conjugated linoleic acid isomers: Differences in metabolism and biological effects

(2009) Itziar Churruca et al.   BIOFACTORS

Hepatotoxicity of high oral dose (−)-epigallocatechin-3-gallate in mice

(2009) Joshua D. Lambert et al.   FOOD AND CHEMICAL TOXICOLOGY

Hepatic Stearoyl-CoA Desaturase (SCD)-1 Activity and Diacylglycerol but Not Ceramide Concentrations Are Increased in the Nonalcoholic Human Fatty Liver

(2008) A. Kotronen et al.   DIABETES

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL