A guide to the regulation of selective autophagy receptors

FAM 134B oligomerization drives endoplasmic reticulum membrane scission for ER ‐phagy

(2020) Xiao Jiang et al.   EMBO JOURNAL

Phase separation organizes the site of autophagosome formation

(2020) Yuko Fujioka et al.   NATURE

Selective autophagy degrades nuclear pore complexes

(2020) Chia-Wei Lee et al.   NATURE CELL BIOLOGY

Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery

(2020) Mija Marinković et al.   Autophagy

A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

(2020) Jin Rui Liang et al.   CELL

TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes

(2020) Yui Tomioka et al.   JOURNAL OF CELL BIOLOGY

Autophagy Regulation by the Translation Machinery and Its Implications in Cancer

(2020) Pilar Sarah Acevo-Rodríguez et al.   Frontiers in Oncology

CALCOCO 1 acts with VAMP ‐associated proteins to mediate ER ‐phagy

(2020) Thaddaeus Mutugi Nthiga et al.   EMBO JOURNAL

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

(2020) Madlen Stephani et al.   eLife

The E3 Ubiquitin Ligase SYVN1 Ubiquitinates Atlastins to Remodel the Endoplasmic Reticulum Network

(2020) Yupeng Zhao et al.   iScience

A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits

(2020) Florian Wilfling et al.   MOLECULAR CELL

Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

(2020) Shireen A. Sarraf et al.   MOLECULAR CELL

NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

(2019) Maria Quiles del Rey et al.   Frontiers in Neuroscience

Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing

(2019) Yifan Zhang et al.   NATURE IMMUNOLOGY

FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates

(2019) Eleonora Turco et al.   MOLECULAR CELL

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

(2019) Jose Norberto S. Vargas et al.   MOLECULAR CELL

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

(2019) Benjamin J. Ravenhill et al.   MOLECULAR CELL

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy

(2019) Qingzhou Chen et al.   CURRENT BIOLOGY

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates

(2019) Serge Ducommun et al.   CELLULAR SIGNALLING

HDAC6 regulates lipid droplet turnover in response to nutrient deprivation via p62-mediated selective autophagy

(2019) Yan Yan et al.   Journal of Genetics and Genomics

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

(2019) Heeseon An et al.   MOLECULAR CELL

Intrinsically Disordered Protein TEX264 Mediates ER-phagy

(2019) Haruka Chino et al.   MOLECULAR CELL

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

(2019) Martina Wirth et al.   Nature Communications

Plant Selective Autophagy - Still an uncharted territory with a lot of hidden gems

(2019) Madlen Stephani et al.   JOURNAL OF MOLECULAR BIOLOGY

Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

(2019) Terje Johansen et al.   JOURNAL OF MOLECULAR BIOLOGY

Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy

(2019) Wenjun Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

(2019) Vladimir Kirkin et al.   MOLECULAR CELL

Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress

(2019) Zhiyuan You et al.   Nature Communications

Dicot-specific ATG8-interacting ATI3 proteins interact with conserved UBAC2 proteins and play critical roles in plant stress responses

(2018) Jie Zhou et al.   Autophagy

Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation

(2018) Daxiao Sun et al.   CELL RESEARCH

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

(2018) Matthew D. Smith et al.   DEVELOPMENTAL CELL

A molecular perspective of mammalian autophagosome biogenesis

(2018) Thomas J. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype

(2018) Yajing Peng et al.   AGING CELL

p62-mediated phase separation at the intersection of the ubiquitin-proteasome system and autophagy

(2018) Alberto Danieli et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells

(2017) Shinwon Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective autophagy limits cauliflower mosaic virus infection by NBR1-mediated targeting of viral capsid protein and particles

(2017) Anders Hafrén et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Timing and Reset Mechanism of GTP Hydrolysis-Driven Conformational Changes of Atlastin

(2017) John P. O'Donnell et al.   STRUCTURE

Ethanol-triggered Lipophagy Requires SQSTM1 in AML12 Hepatic Cells

(2017) Lin Wang et al.   Scientific Reports

Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination

(2017) YouJin Lee et al.   Cell Reports

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

(2017) Paolo Grumati et al.   eLife

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins

(2017) Vladimir V. Rogov et al.   Scientific Reports

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

(2016) Yao Kuang et al.   Autophagy

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

(2016) Chrisovalantis Papadopoulos et al.   EMBO JOURNAL

Higher‐order assemblies of oligomeric cargo receptor complexes form the membrane scaffold of the Cvt vesicle

(2016) Chiara Bertipaglia et al.   EMBO REPORTS

Precision autophagy directed by receptor regulators – emerging examples within the TRIM family

(2016) Tomonori Kimura et al.   JOURNAL OF CELL SCIENCE

TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation

(2016) Michael A. Mandell et al.   JOURNAL OF CELL SCIENCE

TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis

(2016) Ji-An Pan et al.   MOLECULAR CELL

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2016) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

Mechanistic insights into selective autophagy pathways: lessons from yeast

(2016) Jean-Claude Farré et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

(2016) Benjamin Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy

(2016) Lindsey N. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Mechanism of cargo-directed Atg8 conjugation during selective autophagy

(2016) Dorotea Fracchiolla et al.   eLife

Reticulophagy and nucleophagy: New findings and unsolved issues

(2015) Hitoshi Nakatogawa et al.   Autophagy

Hrr25: An emerging major player in selective autophagy regulation inSaccharomyces cerevisiae

(2015) Hitoshi Nakatogawa   Autophagy

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis

(2015) Richard S. Marshall et al.   MOLECULAR CELL

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

ATM functions at the peroxisome to induce pexophagy in response to ROS

(2015) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

Cis and trans interactions between atlastin molecules during membrane fusion

(2015) Tina Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

(2015) Junghyun Lim et al.   PLoS Genetics

The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy

(2015) David A. Tumbarello et al.   PLoS Pathogens

Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis

(2015) Joseph D Mancias et al.   eLife

Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy

(2015) Bettina Wurzer et al.   eLife

Autophagy revisited: A conversation with Christian de Duve

(2014) Daniel J. Klionsky   Autophagy

Posttranslational modification of autophagy-related proteins in macroautophagy

(2014) Yangchun Xie et al.   Autophagy

PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding

(2014) Frank Christian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression

(2014) Zhengzhao Liu et al.   CANCER CELL

Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family

(2014) Kefeng Lu et al.   CELL

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

(2014) F Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Hrr25 kinase promotes selective autophagy by phosphorylating the cargo receptor Atg19

(2014) T. Pfaffenwimmer et al.   EMBO REPORTS

Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of α-mannosidase under nitrogen starvation conditions

(2014) Keisuke Mochida et al.   FEBS LETTERS

Solution Structure of the Ubiquitin-associated (UBA) Domain of Human Autophagy Receptor NBR1 and Its Interaction with Ubiquitin and Polyubiquitin

(2014) Erik Walinda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hrr25 triggers selective autophagy–related pathways by phosphorylating receptor proteins

(2014) Chikara Tanaka et al.   JOURNAL OF CELL BIOLOGY

Regulation of autophagy by protein post-translational modification

(2014) Willayat Yousuf Wani et al.   LABORATORY INVESTIGATION

Membrane tethering by the atlastin GTPase depends on GTP hydrolysis but not on forming the cross-over configuration

(2014) Simran G. Saini et al.   MOLECULAR BIOLOGY OF THE CELL

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Arabidopsis ATG8-INTERACTING PROTEIN1 Is Involved in Autophagy-Dependent Vesicular Trafficking of Plastid Proteins to the Vacuole

(2014) S. Michaeli et al.   PLANT CELL

Oligomerization of Optineurin and Its Oxidative Stress- or E50K Mutation-Driven Covalent Cross-Linking: Possible Relationship with Glaucoma Pathology

(2014) Jie Gao et al.   PLoS One

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy

(2013) Pauline Isakson et al.   Autophagy

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

Structural basis for conformational switching and GTP loading of the large G protein atlastin

(2013) Laura J Byrnes et al.   EMBO JOURNAL

FIP200 regulates targeting of Atg16L1 to the isolation membrane

(2013) Taki Nishimura et al.   EMBO REPORTS

Casein kinase 2 is essential for mitophagy

(2013) Tomotake Kanki et al.   EMBO REPORTS

Phosphorylation of mitophagy and pexophagy receptors coordinates their interaction with Atg8 and Atg11

(2013) Jean-Claude Farré et al.   EMBO REPORTS

Enhanced optineurin E50K–TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma

(2013) Yuriko Minegishi et al.   HUMAN MOLECULAR GENETICS

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

(2013) Naonobu Fujita et al.   JOURNAL OF CELL BIOLOGY

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

The N-Terminal Region of the Human Autophagy Protein ATG16L1 Contains a Domain That Folds into a Helical Structure Consistent with Formation of a Coiled-Coil

(2013) Rhiannon Parkhouse et al.   PLoS One

Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis

(2012) Michael J. Ragusa et al.   CELL

Pex3-anchored Atg36 tags peroxisomes for degradation inSaccharomyces cerevisiae

(2012) Alison M Motley et al.   EMBO JOURNAL

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

(2012) Manohar Pilli et al.   IMMUNITY

Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival MitophagyversusApoptosis

(2012) Yanyan Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates

(2012) J. Korac et al.   JOURNAL OF CELL SCIENCE

NBR1 acts as an autophagy receptor for peroxisomes

(2012) E. Deosaran et al.   JOURNAL OF CELL SCIENCE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex–dependent and –independent autophagy

(2012) Noor Gammoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1

(2011) Steingrim Svenning et al.   Autophagy

Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1

(2011) Sixin Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aspartyl Aminopeptidase Is Imported from the Cytoplasm to the Vacuole by Selective Autophagy inSaccharomyces cerevisiae

(2011) Masaki Yuga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin Interacts with Ambra1 to Induce Mitophagy

(2011) C. Van Humbeeck et al.   JOURNAL OF NEUROSCIENCE

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Membrane fusion by the GTPase atlastin requires a conserved C-terminal cytoplasmic tail and dimerization through the middle domain

(2011) T. J. Moss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes

(2011) X. Bian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A

(2011) L. J. Byrnes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GTP-dependent packing of a three-helix bundle is required for atlastin-mediated fusion

(2011) D. Pendin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation

(2011) David G. McEwan et al.   TRENDS IN CELL BIOLOGY

Atg8-family interacting motif crucial for selective autophagy

(2010) Nobuo N. Noda et al.   FEBS LETTERS

The Cvt pathway as a model for selective autophagy

(2010) Melinda A. Lynch-Day et al.   FEBS LETTERS

Selective Transport of α-Mannosidase by Autophagic Pathways

(2010) Kuninori Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Posttranslational Modifications, Localization, and Protein Interactions of Optineurin, the Product of a Glaucoma Gene

(2010) Hongyu Ying et al.   PLoS One

Autophagy: links with the proteasome

(2009) Trond Lamark et al.   CURRENT OPINION IN CELL BIOLOGY

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

(2009) Tomotake Kanki et al.   DEVELOPMENTAL CELL

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

(2009) Koji Okamoto et al.   DEVELOPMENTAL CELL

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

(2009) Y. T. Zheng et al.   JOURNAL OF IMMUNOLOGY

Dimerisation of the UBA Domain of p62 Inhibits Ubiquitin Binding and Regulates NF-κB Signalling

(2009) Jed Long et al.   JOURNAL OF MOLECULAR BIOLOGY

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

(2009) Teresa L M Thurston et al.   NATURE IMMUNOLOGY

PpAtg30 Tags Peroxisomes for Turnover by Selective Autophagy

(2008) Jean-Claude Farré et al.   DEVELOPMENTAL CELL

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

Midbody ring disposal by autophagy is a post-abscission event of cytokinesis

(2008) Christian Pohl et al.   NATURE CELL BIOLOGY