The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death

The Alzheimer’s Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease

(2020) Dimitrios A. Stakos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury

(2020) Jihoon Nah et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis for autophagy inhibition by the human Rubicon–Rab7 complex

(2020) Hersh K. Bhargava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

(2020) Tadashi Yamamuro et al.   Nature Communications

Hepatitis C virus enhances Rubicon expression, leading to autophagy inhibition and intracellular innate immune activation

(2020) Yuto Shiode et al.   Scientific Reports

Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease

(2020) Bradlee L. Heckmann et al.   Science Advances

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Cardiac Autophagy in Sepsis

(2019) Yuxiao Sun et al.   Cells

LC3-associated phagocytosis at a glance

(2019) Bradlee L. Heckmann et al.   JOURNAL OF CELL SCIENCE

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2019) Bradlee L. Heckmann et al.   CELL

Loss of Rubicon ameliorates doxorubicin-induced cardiotoxicity through enhancement of mitochondrial quality

(2019) Xiaoyun Liu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Comprehensive autophagy evaluation in cardiac disease models

(2019) Nina Kaludercic et al.   CARDIOVASCULAR RESEARCH

CARD9 inhibits mitochondria-dependent apoptosis of cardiomyocytes under oxidative stress via interacting with Apaf-1

(2019) Yuanbin Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

HUNK Phosphorylates Rubicon to Support Autophagy

(2019) Joelle N. Zambrano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Viral escape from endosomes and host detection at a glance

(2018) Jacqueline Staring et al.   JOURNAL OF CELL SCIENCE

Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics

(2018) Chunmei Chang et al.   MOLECULAR CELL

Rubicon: LC3-associated phagocytosis and beyond

(2017) Sing-Wai Wong et al.   FEBS Journal

Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex

(2017) Goran Stjepanovic et al.   MOLECULAR CELL

Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17

(2017) Xiawei Cheng et al.   MOLECULAR CELL

Peptide inhibition of p22phox and Rubicon interaction as a therapeutic strategy for septic shock

(2016) Ye-Ram Kim et al.   BIOMATERIALS

Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome AcidificationCLINICAL PERSPECTIVE

(2016) Dan L. Li et al.   CIRCULATION

Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease in mice

(2016) Satoshi Tanaka et al.   HEPATOLOGY

CARD9 as a potential target in cardiovascular disease

(2016) Matthew R. Peterson et al.   Drug Design Development and Therapy

Rubicon Deficiency Enhances Cardiac Autophagy and Protects Mice From Lipopolysaccharide-induced Lethality and Reduction in Stroke Volume

(2015) Zhenguo Zi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

(2015) Young-Mi Kim et al.   MOLECULAR CELL

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK

(2014) Xue Wang et al.   BIOCHEMICAL PHARMACOLOGY

Oxidative stress in rheumatoid arthritis patients: relationship to diseases activity

(2014) Mirjana Veselinovic et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited

(2013) J. David Lambeth et al.   Annual Review of Pathology-Mechanisms of Disease

Kaposi's Sarcoma-Associated Herpesvirus K7 Modulates Rubicon-Mediated Inhibition of Autophagosome Maturation

(2013) Q. Liang et al.   JOURNAL OF VIROLOGY

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

The Autophagy Regulator Rubicon Is a Feedback Inhibitor of CARD9-Mediated Host Innate Immunity

(2012) Chul-Su Yang et al.   Cell Host & Microbe

Autophagy Protein Rubicon Mediates Phagocytic NADPH Oxidase Activation in Response to Microbial Infection or TLR Stimulation

(2012) Chul-Su Yang et al.   Cell Host & Microbe

Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein

(2012) Weijiao Huang et al.   CELL RESEARCH

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Age As a Risk Factor

(2011) Ravi Dhingra et al.   MEDICAL CLINICS OF NORTH AMERICA

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Endotoxin impairs cardiac hemodynamics by affecting loading conditions but not by reducing cardiac inotropism

(2010) Li Jianhui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The RUN Domain of Rubicon Is Important for hVps34 Binding, Lipid Kinase Inhibition, and Autophagy Suppression

(2010) Qiming Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

(2010) Kohichi Matsunaga et al.   JOURNAL OF CELL BIOLOGY

Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain

(2010) Keisuke Tabata et al.   MOLECULAR BIOLOGY OF THE CELL

Rubicon controls endosome maturation as a Rab7 effector

(2010) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral Myocarditis

(2009) Toshitaka Yajima et al.   CIRCULATION

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

CARD9 versus CARMA1 in innate and adaptive immunity

(2009) Hiromitsu Hara et al.   TRENDS IN IMMUNOLOGY

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY