Recombinant protein secretion by Bacillus subtilis and Lactococcus lactis: pathways, applications, and innovation potential

Relative contributions of non-essential Sec pathway components and cell envelope-associated proteases to high-level enzyme secretion by Bacillus subtilis

(2020) Jolanda Neef et al.   Microbial Cell Factories

Engineering Bacillus subtilis Cells as Factories: Enzyme Secretion and Value-added Chemical Production

(2020) Ken-ichi Yoshida et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Identification and optimization of PrsA in Bacillus subtilis for improved yield of amylase

(2019) Ane Quesada-Ganuza et al.   Microbial Cell Factories

Less Is More: Toward a Genome-Reduced Bacillus Cell Factory for “Difficult Proteins”

(2018) Rocío Aguilar Suárez et al.   ACS Synthetic Biology

Bacterial Excretion of Cytoplasmic Proteins (ECP): Occurrence, Mechanism, and Function

(2018) Patrick Ebner et al.   TRENDS IN MICROBIOLOGY

Intramembrane protease RasP boosts protein production in Bacillus

(2017) Jolanda Neef et al.   Microbial Cell Factories

Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis

(2017) Masanori Toyofuku et al.   Nature Communications

Multimer recognition and secretion by the non-classical secretion pathway in Bacillus subtilis

(2017) Liuqun Zhao et al.   Scientific Reports

Non-classical Protein Excretion Is Boosted by PSMα-Induced Cell Leakage

(2017) Patrick Ebner et al.   Cell Reports

Large-scale reduction of theBacillus subtilisgenome: consequences for the transcriptional network, resource allocation, and metabolism

(2016) Daniel R. Reuß et al.   GENOME RESEARCH

Excreted Cytoplasmic Proteins Contribute to Pathogenicity in Staphylococcus aureus

(2016) Patrick Ebner et al.   INFECTION AND IMMUNITY

Mass Spectrometry Analysis of the Extracellular Peptidome of Lactococcus lactis: Lines of Evidence for the Coexistence of Extracellular Protein Hydrolysis and Intracellular Peptide Excretion

(2016) Alain Guillot et al.   JOURNAL OF PROTEOME RESEARCH

A novel strategy for protein production using non-classical secretion pathway in Bacillus subtilis

(2016) Jingqi Chen et al.   Microbial Cell Factories

Protein export through the bacterial Sec pathway

(2016) Alexandra Tsirigotaki et al.   NATURE REVIEWS MICROBIOLOGY

Versatile vector suite for the extracytoplasmic production and purification of heterologous His-tagged proteins in Lactococcus lactis

(2015) Jolanda Neef et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Excretion of cytoplasmic proteins in Staphylococcus is most likely not due to cell lysis

(2015) Patrick Ebner et al.   CURRENT GENETICS

Cloning of LicB from Clostridium thermocellum and its efficient secretive expression of thermostable β-1,3-1,4-glucanase

(2014) Zichen Luo et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Efficient production of secreted staphylococcal antigens in a non-lysing and proteolytically reduced Lactococcus lactis strain

(2014) Jolanda Neef et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Sec-secretion and sortase-mediated anchoring of proteins in Gram-positive bacteria

(2013) Olaf Schneewind et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Extracytoplasmic Proteases Determining the Cleavage and Release of Secreted Proteins, Lipoproteins, and Membrane Proteins in Bacillus subtilis

(2013) Laxmi Krishnappa et al.   JOURNAL OF PROTEOME RESEARCH

Bacillus subtilis: from soil bacterium to super-secreting cell factory

(2013) Jan Maarten van Dijl et al.   Microbial Cell Factories

Proteomic analysis ofBacillus subtilisstrains engineered for improved production of heterologous proteins

(2013) Susanne Pohl et al.   PROTEOMICS

Membrane Proteases in the Bacterial Protein Secretion and Quality Control Pathway

(2012) R. E. Dalbey et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Protein transport across the cell wall of monoderm Gram-positive bacteria

(2012) Brian M. Forster et al.   MOLECULAR MICROBIOLOGY

Functional Implementation of the Posttranslational SecB-SecA Protein-Targeting Pathway in Bacillus subtilis

(2011) Liuyang Diao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Nonclassical Protein Secretion by Bacillus subtilis in the Stationary Phase Is Not Due to Cell Lysis

(2011) C.-K. Yang et al.   JOURNAL OF BACTERIOLOGY

Moonlighting proteins: An intriguing mode of multitasking

(2010) Daphne H.E.W. Huberts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Staphylococcal Major Autolysin (Atl) Is Involved in Excretion of Cytoplasmic Proteins

(2010) Linda Pasztor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Extracellular Production of Heterologous Proteins in Bacillus subtilis by Deleting the C-terminal Region of the SecA Secretory Machinery

(2010) Hiroshi Kakeshtia et al.   MOLECULAR BIOTECHNOLOGY

Protein transport across and into cell membranes in bacteria and archaea

(2009) Jijun Yuan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Single proteins might have dual but related functions in intracellular and extracellular microenvironments

(2009) Derek C. Radisky et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HtrA Is Essential for Efficient Secretion of Recombinant Proteins by Lactococcus lactis

(2008) K. Sriraman et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Genetic or chemical protease inhibition causes significant changes in the Bacillus subtilis exoproteome

(2008) Lidia Westers et al.   PROTEOMICS

Bacillus protein secretion: an unfolding story

(2008) Colin R. Harwood et al.   TRENDS IN MICROBIOLOGY

Ecology and genomics of Bacillus subtilis

(2008) Ashlee M. Earl et al.   TRENDS IN MICROBIOLOGY