Reply to the commentary by Ben‐Ari and Delpire: Bumetanide and neonatal seizures: Fiction versus reality

Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

(2021) Huixin Xu et al.   Nature Communications

Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details

(2021) Yehezkel Ben‐Ari et al.   EPILEPSIA

The Multifaceted Roles of KCC2 in Cortical Development

(2021) Mari A. Virtanen et al.   TRENDS IN NEUROSCIENCES

Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy

(2021) Philip Hampel et al.   NEUROBIOLOGY OF DISEASE

Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?

(2020) Wolfgang Löscher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endogenous brain‐sparing responses in brain pH and P O2 in a rodent model of birth asphyxia

(2020) Alexey S. Pospelov et al.   Acta Physiologica

Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options

(2020) Wolfgang Löscher et al.   PHARMACOLOGICAL REVIEWS

LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia

(2020) Christian Henneberger et al.   NEURON

A Pilot Randomized, Controlled, Double‐Blind Trial of Bumetanide to Treat Neonatal Seizures

(2020) Janet S. Soul et al.   ANNALS OF NEUROLOGY

Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective

(2020) Marie Johne et al.   EPILEPSIA

A physiologically validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia

(2020) Tommi Ala‐Kurikka et al.   EPILEPSIA

NKCC1, an Elusive Molecular Target in Brain Development: Making Sense of the Existing Data

(2020) Mari A. Virtanen et al.   Cells

Evaluating anti-epileptic drugs in the era of therapeutic hypothermia

(2019) Joanne O. Davidson et al.   PEDIATRIC RESEARCH

Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital’s anti-seizure efficacy

(2018) Claudia Brandt et al.   NEUROPHARMACOLOGY

Recommendations for the design of therapeutic trials for neonatal seizures

(2018) Janet S. Soul et al.   PEDIATRIC RESEARCH

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain

(2017) Kerstin Römermann et al.   NEUROPHARMACOLOGY

Vasopressin excites interneurons to suppress hippocampal network activity across a broad span of brain maturity at birth

(2017) Albert Spoljaric et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives

(2016) Maria D. Donovan et al.   DRUGS

The search for NKCC1-selective drugs for the treatment of epilepsy: Structure–function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A

(2016) Kasper Lykke et al.   EPILEPSY & BEHAVIOR

Failure of the Nemo Trial: Bumetanide Is a Promising Agent to Treat Many Brain Disorders but Not Newborn Seizures

(2016) Yehezkel Ben-Ari et al.   Frontiers in Cellular Neuroscience

Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter

(2015) Kasper Lykke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial

(2015) Ronit M Pressler et al.   LANCET NEUROLOGY

Treatment during a vulnerable developmental period rescues a genetic epilepsy

(2015) Stephan Lawrence Marguet et al.   NATURE MEDICINE

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

(2014) Kathrin Töllner et al.   ANNALS OF NEUROLOGY

Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures

(2014) Martin Puskarjov et al.   EPILEPSIA

Cation-chloride cotransporters in neuronal development, plasticity and disease

(2014) Kai Kaila et al.   NATURE REVIEWS NEUROSCIENCE

GABA actions and ionic plasticity in epilepsy

(2013) Kai Kaila et al.   CURRENT OPINION IN NEUROBIOLOGY

Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures

(2013) Ryan T. Cleary et al.   PLoS One

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

(2012) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

Loop Diuretics Have Anxiolytic Effects in Rat Models of Conditioned Anxiety

(2012) Andrew D. Krystal et al.   PLoS One

Clinical Pharmacology of the Loop Diuretics Furosemide and Bumetanide in Neonates and Infants

(2012) Gian Maria Pacifici   PEDIATRIC DRUGS

Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissue

(2011) Yijun Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Expression of GABA Signaling Molecules KCC2, NKCC1, and GAD1 in Cortical Development and Schizophrenia

(2011) T. M. Hyde et al.   JOURNAL OF NEUROSCIENCE

Loss of Cation-Chloride Cotransporter Expression in Preterm Infants With White Matter Lesions: Implications for the Pathogenesis of Epilepsy

(2010) Shenandoah Robinson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Disease-Modifying Effects of Phenobarbital and the NKCC1 Inhibitor Bumetanide in the Pilocarpine Model of Temporal Lobe Epilepsy

(2010) C. Brandt et al.   JOURNAL OF NEUROSCIENCE

Bumetanide for neonatal seizures: Based on evidence or enthusiasm?

(2009) Sampsa Vanhatalo et al.   EPILEPSIA