Cadmium exposure induces rat proximal tubular cells injury via p62-dependent Nrf2 nucleus translocation mediated activation of AMPK/AKT/mTOR pathway

Nrf2 positively regulates autophagy antioxidant response in human bronchial epithelial cells exposed to diesel exhaust particles

(2020) Daniela Perroni Frias et al.   Scientific Reports

The Effects of Cadmium Toxicity

(2020) Giuseppe Genchi et al.   International Journal of Environmental Research and Public Health

Puerarin restores the autophagic flux to alleviate cadmium‑induced endoplasmic reticulum stress in NRK‑52E cells

(2020) Gang Liu et al.   Molecular Medicine Reports

Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System

(2020) Md. Abdul Hannan et al.   Frontiers in Molecular Neuroscience

Inhibition of autophagy enhances cadmium-induced apoptosis in duck renal tubular epithelial cells

(2020) Chang Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

SQSTM1/p62: a potential target for neurodegenerative disease

(2019) Shifan Ma et al.   ACS Chemical Neuroscience

Cadmium effects on superoxide dismutase 1 in human cells revealed by NMR

(2019) Panagis Polykretis et al.   Redox Biology

Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

(2019) Zehan Tang et al.   Cell Death & Disease

Trehalose suppresses cadmium-activated Nrf2 signaling pathway to protect against spleen injury

(2019) Kui-Chao Qu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Cadmium exposure triggers mitochondrial dysfunction and oxidative stress in chicken (Gallus gallus) kidney via mitochondrial UPR inhibition and Nrf2-mediated antioxidant defense activation

(2019) Jing Ge et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane

(2018) Yuting Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma

(2018) Desirée Bartolini et al.   Translational Research

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

(2018) Elizabeth C Hinchy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress

(2018) Monika Kosztelnik et al.   FASEB JOURNAL

Autophagy promotes angiogenesis via AMPK/Akt/mTOR signaling during the recovery of heat-denatured endothelial cells

(2018) Pengfei Liang et al.   Cell Death & Disease

Alleviation of cadmium-induced oxidative stress by trehalose via inhibiting the Nrf2-Keap1 signaling pathway in primary rat proximal tubular cells

(2017) Xin-Yu Wang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells

(2017) Xiang-Bin Song et al.   Cell Death & Disease

Analyzing the role of soil and rice cadmium pollution on human renal dysfunction by correlation and path analysis

(2016) Hui-Fang Luo et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Cadmium toxicity induces ER stress and apoptosis via impairing energy homeostasis in cardiomyocytes

(2015) Chun-yan Chen et al.   BIOSCIENCE REPORTS

Cadmium or cadmium compounds and chronic kidney disease in workers and the general population: a systematic review

(2015) Katarzyna Byber et al.   CRITICAL REVIEWS IN TOXICOLOGY

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62/SQSTM1 at the interface of aging, autophagy, and disease

(2014) Alessandro Bitto et al.   AGE

Glutathione and mitochondria determine acute defense responses and adaptive processes in cadmium-induced oxidative stress and toxicity of the kidney

(2014) Ambily Ravindran Nair et al.   ARCHIVES OF TOXICOLOGY

Nrf2/p62 Signaling in Apoptosis Resistance and Its Role in Cadmium-induced Carcinogenesis

(2014) Young-Ok Son et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cadmium and cellular signaling cascades: interactions between cell death and survival pathways

(2013) Frank Thévenod et al.   ARCHIVES OF TOXICOLOGY

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cullin 3 as a novel target in diverse pathologies

(2013) Ana Cristina Andérica-Romero et al.   Redox Biology

Simultaneous Effects of Lead and Cadmium on Primary Cultures of Rat Proximal Tubular Cells: Interaction of Apoptosis and Oxidative Stress

(2011) Lin Wang et al.   ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Heavy metal poisoning: the effects of cadmium on the kidney

(2010) Nikhil Johri et al.   BIOMETALS

Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death

(2010) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

(2010) Ian M. Copple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

A review of human carcinogens—Part C: metals, arsenic, dusts, and fibres

(2009) Kurt Straif et al.   LANCET ONCOLOGY

Role of oxidative stress in cadmium toxicity and carcinogenesis

(2009) Jie Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1

(2007) E. Olatunde Farombi et al.   FOOD AND CHEMICAL TOXICOLOGY