Mammalian primordial germ cell specification

Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage

(2021) Qifan Zhu et al.   Cell Reports

Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate

(2020) Evan S. Bardot et al.   MECHANISMS OF DEVELOPMENT

A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons

(2020) Anastasiya Sybirna et al.   Nature Communications

An in vitro model of early anteroposterior organization during human development

(2020) Naomi Moris et al.   NATURE

Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation

(2020) Tsotne Chitiashvili et al.   NATURE CELL BIOLOGY

Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse

(2019) Anna D. Senft et al.   Nature Communications

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

Induction of the germ cell fate from pluripotent stem cells in cynomolgus monkeys†

(2019) Yoshitake Sakai et al.   BIOLOGY OF REPRODUCTION

In vitro culture of cynomolgus monkey embryos beyond early gastrulation

(2019) Huaixiao Ma et al.   SCIENCE

Dissecting primate early post-implantation development using long-term in vitro embryo culture

(2019) Yuyu Niu et al.   SCIENCE

A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans

(2019) Miguel Casanova et al.   Nature Communications

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors

(2019) Di Chen et al.   Cell Reports

Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells

(2018) Ábel Vértesy et al.   Nature Communications

The Kyoto Collection of Human Embryos and Fetuses: History and Recent Advancements in Modern Methods

(2018) Yutaka Yamaguchi et al.   CELLS TISSUES ORGANS

Single-cell RNA-sequencing reveals the existence of naive and primed pluripotency in pre-implantation rhesus monkey embryos

(2018) Denghui Liu et al.   GENOME RESEARCH

Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

(2018) Peter W. S. Hill et al.   NATURE

Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development

(2018) Thorsten Boroviak et al.   DEVELOPMENT

Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche

(2018) Enrique Sosa et al.   Nature Communications

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

(2017) Marta N. Shahbazi et al.   NATURE

Principles of early human development and germ cell program from conserved model systems

(2017) Toshihiro Kobayashi et al.   NATURE

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

(2017) Sarah Ellys Harrison et al.   SCIENCE

Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation

(2017) Sanjeet Patel et al.   Cell Reports

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells

(2016) Kenjiro Shirane et al.   DEVELOPMENTAL CELL

Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification

(2016) Ferdinand von Meyenn et al.   DEVELOPMENTAL CELL

The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion

(2016) Kotaro Sasaki et al.   DEVELOPMENTAL CELL

Embryology policy: Revisit the 14-day rule

(2016) Insoo Hyun et al.   NATURE

Self-organization of the in vitro attached human embryo

(2016) Alessia Deglincerti et al.   NATURE

NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers

(2016) Kazuhiro Murakami et al.   NATURE

A developmental coordinate of pluripotency among mice, monkeys and humans

(2016) Tomonori Nakamura et al.   NATURE

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

DNA Demethylation Dynamics in the Human Prenatal Germline

(2015) Sofia Gkountela et al.   CELL

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

(2015) Walfred W.C. Tang et al.   CELL

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

(2015) Naoko Irie et al.   CELL

Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

(2015) Kotaro Sasaki et al.   Cell Stem Cell

Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis

(2015) Thorsten Boroviak et al.   DEVELOPMENTAL CELL

An alternative pluripotent state confers interspecies chimaeric competency

(2015) Jun Wu et al.   NATURE

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

(2014) Thorold W. Theunissen et al.   Cell Stem Cell

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

In vitro culture of mouse blastocysts beyond the implantation stages

(2014) Ivan Bedzhov et al.   Nature Protocols

The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak

(2013) Yoji Kojima et al.   Cell Stem Cell

A Mesodermal Factor, T, Specifies Mouse Germ Cell Fate by Directly Activating Germline Determinants

(2013) Shinya Aramaki et al.   DEVELOPMENTAL CELL

High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice

(2013) H. Kobayashi et al.   GENOME RESEARCH

Induction of mouse germ-cell fate by transcription factors in vitro

(2013) Fumio Nakaki et al.   NATURE

A tripartite transcription factor network regulates primordial germ cell specification in mice

(2013) Erna Magnúsdóttir et al.   NATURE CELL BIOLOGY

XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells

(2013) Céline Vallot et al.   NATURE GENETICS

Dullard/Ctdnep1 Modulates WNT Signalling Activity for the Formation of Primordial Germ Cells in the Mouse Embryo

(2013) Satomi S. Tanaka et al.   PLoS One

Erosion of Dosage Compensation Impacts Human iPSC Disease Modeling

(2012) Shila Mekhoubad et al.   Cell Stem Cell

Global profiling of DNA methylation erasure in mouse primordial germ cells

(2012) S. Guibert et al.   GENOME RESEARCH

The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells

(2012) Stefanie Seisenberger et al.   MOLECULAR CELL

A unique regulatory phase of DNA methylation in the early mammalian embryo

(2012) Zachary D. Smith et al.   NATURE

Offspring from Oocytes Derived from in Vitro Primordial Germ Cell-like Cells in Mice

(2012) K. Hayashi et al.   SCIENCE

Primordial Germ Cells in Mice

(2012) M. Saitou et al.   Cold Spring Harbor Perspectives in Biology

In Vivo Differentiation Potential of Epiblast Stem Cells Revealed by Chimeric Embryo Formation

(2012) Yali Huang et al.   Cell Reports

Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

(2011) Katsuhiko Hayashi et al.   CELL

Distinct Developmental Ground States of Epiblast Stem Cell Lines Determine Different Pluripotency Features

(2011) Christof Bernemann et al.   STEM CELLS

Developmental Stages in Human Embryos: Revised and New Measurements

(2010) Ronan O’Rahilly et al.   CELLS TISSUES ORGANS

Making the blastocyst: lessons from the mouse

(2010) Katie Cockburn et al.   JOURNAL OF CLINICAL INVESTIGATION

Germ cell specification in mice: signaling, transcription regulation, and epigenetic consequences

(2010) Mitinori Saitou et al.   REPRODUCTION

Critical Function of AP-2gamma/TCFAP2C in Mouse Embryonic Germ Cell Maintenance1

(2009) Susanne Weber et al.   BIOLOGY OF REPRODUCTION

Nanog Is the Gateway to the Pluripotent Ground State

(2009) Jose Silva et al.   CELL

A Signaling Principle for the Specification of the Germ Cell Lineage in Mice

(2009) Yasuhide Ohinata et al.   CELL

Metastable Pluripotent States in NOD-Mouse-Derived ESCs

(2009) Jacob Hanna et al.   Cell Stem Cell

Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro

(2009) K. Hayashi et al.   DEVELOPMENT

Klf4 reverts developmentally programmed restriction of ground state pluripotency

(2009) G. Guo et al.   DEVELOPMENT

Development and function of trophoblast giant cells in the rodent placenta

(2009) Dong Hu et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells

(2009) Siqin Bao et al.   NATURE

Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice

(2008) K. Kurimoto et al.   GENES & DEVELOPMENT

Critical function of Prdm14 for the establishment of the germ cell lineage in mice

(2008) Masashi Yamaji et al.   NATURE GENETICS

X Chromosome Activity in Mouse XX Primordial Germ Cells

(2008) Susana M. Chuva de Sousa Lopes et al.   PLoS Genetics