PPARγ and Diabetes: Beyond the Genome and Towards Personalized Medicine

In Vitro-Generated Hypertrophic-Like Adipocytes Displaying PPARG Isoforms Unbalance Recapitulate Adipocyte Dysfunctions In Vivo

(2020) Marianna Aprile et al.   Cells

PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis

(2020) Negar Sarhangi et al.   Scientific Reports

Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

(2020) Jessica A. Hall et al.   Cell Metabolism

TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance

(2019) Dalila El Ouarrat et al.   Cell Metabolism

A Pharmacogenetic Approach to the Treatment of Patients WithPPARGMutations

(2018) Maura Agostini et al.   DIABETES

Functional Regulation of PPARs through Post-Translational Modifications

(2018) Reinhard Brunmeir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PPARγ deacetylation dissociates thiazolidinedione’s metabolic benefits from its adverse effects

(2018) Michael J. Kraakman et al.   JOURNAL OF CLINICAL INVESTIGATION

Screening for PPAR Non-Agonist Ligands Followed by Characterization of a Hit, AM-879, with Additional No-Adipogenic and cdk5-Mediated Phosphorylation Inhibition Properties

(2018) Helder Veras Ribeiro Filho et al.   Frontiers in Endocrinology

Assessment of the Pro12Ala Polymorphism in the PPAR-γ2 Gene among Type 2 Diabetes Patients in a Nigerian Population

(2018) Godwill Engwa et al.   Journal of Clinical Medicine

Effects of telmisartan on TNFα induced PPARγ phosphorylation and insulin resistance in adipocytes

(2018) Tao Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PPARγ-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice

(2018) Takeshi Katafuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation

(2018) Marianna Aprile et al.   Cell Reports

Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1 + Adipocytes

(2016) Hong Wang et al.   Cell Metabolism

Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity

(2016) Peishan Li et al.   DIABETES

Familial partial lipodystrophy linked to a novel peroxisome proliferator activator receptor -γ (PPARG) mutation, H449L: a comparison of people with this mutation and those with classic codon 482 Lamin A/C (LMNA) mutations

(2016) T. Demir et al.   DIABETIC MEDICINE

Prospective functional classification of all possible missense variants in PPARG

(2016) Amit R Majithia et al.   NATURE GENETICS

The C1431T polymorphism of peroxisome proliferator activated receptor γ (PPARγ) is associated with low risk of diabetes in a Pakistani cohort

(2016) Huma Butt et al.   Diabetology & Metabolic Syndrome

Association between PPAR-γ2 Pro12Ala genotype and insulin resistance is modified by circulating lipids in Mexican children

(2016) Carolina Stryjecki et al.   Scientific Reports

Allosteric Pathways in the PPARγ-RXRα nuclear receptor complex

(2016) Clarisse G. Ricci et al.   Scientific Reports

Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis

(2015) Anahita Mansoori et al.   ANNALS OF NUTRITION AND METABOLISM

L312, a novel PPARγ ligand with potent anti-diabetic activity by selective regulation

(2015) Xinni Xie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga +/- mice

(2015) Yong Ryoul Yang et al.   DIABETOLOGIA

Relation between BMI and Diabetes Mellitus and Its Complications among US Older Adults

(2015) Natallia Gray et al.   SOUTHERN MEDICAL JOURNAL

Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies?

(2015) Carla Pollastro et al.   PPAR Research

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

(2015) Douglas J. Kojetin et al.   Nature Communications

Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming

(2014) Jang Hyun Choi et al.   GENES & DEVELOPMENT

Minireview: Challenges and Opportunities in Development of PPAR Agonists

(2014) Matthew B. Wright et al.   MOLECULAR ENDOCRINOLOGY

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

(2014) Alexander S. Banks et al.   NATURE

Partial Agonist, Telmisartan, Maintains PPARγ Serine 112 Phosphorylation, and Does Not Affect Osteoblast Differentiation and Bone Mass

(2014) Vipula Kolli et al.   PLoS One

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

(2014) A. R. Majithia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARγ and the global map of adipogenesis and beyond

(2014) Martina I. Lefterova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PPARGin Human Adipogenesis: Differential Contribution of Canonical Transcripts and Dominant Negative Isoforms

(2014) M. Aprile et al.   PPAR Research

Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases

(2013) Francisco A. Monsalve et al.   MEDIATORS OF INFLAMMATION

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Pro12Ala variant of thePPARG2gene increases body mass index: An updated meta-analysis encompassing 49,092 subjects

(2013) C. Galbete et al.   Obesity

Telmisartan at 80 mg/Day Increases High-Molecular-Weight Adiponectin Levels and Improves Insulin Resistance in Diabetic Patients

(2012) Hiroko Mori et al.   ADVANCES IN THERAPY

Adipogenesis: From Stem Cell to Adipocyte

(2012) Qi Qun Tang et al.   Annual Review of Biochemistry

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

SUMO-1 Regulates Body Weight and Adipogenesis via PPARγ in Male and Female Mice

(2012) Laura Mikkonen et al.   ENDOCRINOLOGY

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

O-GlcNAc modification of PPARγ reduces its transcriptional activity

(2011) Suena Ji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

(2011) Pingping Li et al.   CELL

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

SUMO playing tag with ubiquitin

(2011) Gerrit J.K. Praefcke et al.   TRENDS IN BIOCHEMICAL SCIENCES

PPARγ population shift produces disease-related changes in molecular networks associated with metabolic syndrome

(2011) W Jurkowski et al.   Cell Death & Disease

The Association Between the Peroxisome Proliferator-Activated Receptor-γ2 (PPARG2) Pro12Ala Gene Variant and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis

(2010) Hebe N. Gouda et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Thermodynamic Consequences of Incorporating 4-Substituted Proline Derivatives into a Small Helical Protein

(2010) Tong-Yuan Zheng et al.   BIOCHEMISTRY

Telmisartan alleviates rosiglitazone-induced bone loss in ovariectomized spontaneous hypertensive rats

(2010) L. Ma et al.   BONE

Nutritional genomics era: opportunities toward a genome-tailored nutritional regimen

(2010) Valerio Costa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Common polymorphisms of the peroxisome proliferator-activated receptor–γ (Pro12Ala) and peroxisome proliferator-activated receptor–γ coactivator–1 (Gly482Ser) and the response to pioglitazone in Chinese patients with type 2 diabetes mellitus

(2010) Ming-Chia Hsieh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Control of Adipogenesis by the SUMO-Specific Protease SENP2

(2010) S. S. Chung et al.   MOLECULAR AND CELLULAR BIOLOGY

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

(2010) Limin Han et al.   NUCLEIC ACIDS RESEARCH

PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues

(2010) Valerio Costa et al.   PPAR Research

Vertebrate Sex Steroid Receptors: Evolution, Ligands, and Neurodistribution

(2009) Giulia Guerriero   Annals of the New York Academy of Sciences

The Pro12Ala PPARγ2 Variant Determines Metabolism at the Gene-Environment Interface

(2009) Sami Heikkinen et al.   Cell Metabolism

The PPARγ Pro12Ala variant is associated with insulin sensitivity in Russian normoglycaemic and type 2 diabetic subjects

(2009) Dimitry A. Chistiakov et al.   Diabetes & Vascular Disease Research

Pro12Ala Polymorphism in the PPARG Gene Contributes to the Development of Diabetic Nephropathy in Chinese Type 2 Diabetic Patients

(2009) L. Liu et al.   DIABETES CARE

A Selective Peroxisome Proliferator-Activated Receptor-γ Modulator, Telmisartan, Binds to the Receptor in a Different Fashion from Thiazolidinediones

(2009) Tetsuya Tagami et al.   ENDOCRINOLOGY

SUMOylation Attenuates the Function of PGC-1α

(2009) Miia M. Rytinki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Posttranslational Modifications of PPAR-γ: Fine-tuning the Metabolic Master Regulator

(2009) Olivier van Beekum et al.   Obesity

Regulation of Translational Efficiency by Disparate5′-UTRs of PPARγSplice Variants

(2009) Shawn McClelland et al.   PPAR Research

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

PPARγ-independent antitumor effects of thiazolidinediones

(2008) Shuo Wei et al.   CANCER LETTERS

A Novel Mechanism by Which Thiazolidinediones Facilitate the Proteasomal Degradation of Cyclin D1 in Cancer Cells

(2008) Shuo Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Novel Polymorphism in PPARG Regulatory Region Associated with Type 2 Diabetes and Diabetic Retinopathy in Italy

(2008) Valerio Costa et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE