Comparative transcriptomics and network pharmacology analysis to identify the potential mechanism of celastrol against osteoarthritis

Celastrol ameliorates endoplasmic stress‐mediated apoptosis of osteoarthritis via regulating ATF‐6/CHOP signalling pathway

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Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling

(2020) Li Li et al.   Aging-US

Celastrol protects human retinal pigment epithelial cells against hydrogen peroxide mediated oxidative stress, autophagy, and apoptosis through sirtuin 3 signal pathway

(2019) Zhaojiang Du et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Treatment of Neurodegenerative Diseases with Bioactive Components of Tripterygium wilfordii

(2019) Jianheng Li et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

NF-κB Signaling Regulates Physiological and Pathological Chondrogenesis

(2019) Eijiro Jimi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

What did we learn from ‘omics’ studies in osteoarthritis

(2018) Cristina Ruiz-Romero et al.   CURRENT OPINION IN RHEUMATOLOGY

A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F

(2018) Shao-Ru Chen et al.   Frontiers in Pharmacology

Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics

(2018) Win Min Oo et al.   EXPERT OPINION ON EMERGING DRUGS

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(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

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(2018) J. Sherwood   OSTEOARTHRITIS AND CARTILAGE

Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells

(2018) Xiaoli Li et al.   OncoTargets and Therapy

Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats

(2017) Weifeng Wang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

(2017) Mengjie Hu et al.   MOLECULAR CELL

Celastrol alleviates angiotensin II-mediated vascular smooth muscle cell senescence via induction of autophagy

(2017) Xian-Jie Xu et al.   Molecular Medicine Reports

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Inhibition of angiogenesis by arsenic trioxide via TSP-1–TGF-β1-CTGF–VEGF functional module in rheumatoid arthritis

(2017) Juan Zhang et al.   Oncotarget

Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1

(2017) Yinliang Zhang et al.   Molecular Metabolism

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

(2016) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells

(2016) Xiaoling Zhang et al.   Oncotarget

Control of autoimmune inflammation by celastrol, a natural triterpenoid

(2016) Shivaprasad H. Venkatesha et al.   Pathogens and Disease

Treatment of Obesity with Celastrol

(2015) Junli Liu et al.   CELL

mTOR: A Potential Therapeutic Target in Osteoarthritis?

(2015) Bandna Pal et al.   Drugs in research & development

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

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Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes

(2013) Qian-hai Ding et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation

(2013) K Ito et al.   ONCOGENE

Enhancement of radiation sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90

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